Age-related macular degeneration
- Choroidal pericytes promote subretinal fibrosis after experimental photocoagulation
Summary: Using a laser-induced photocoagulation model with collagen 1α1-GFP reporter mice, we identified choroidal pericytes as potential therapeutic targets to prevent subretinal fibrosis for management of neovascular age-related macular degeneration.
- Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
Summary: Ubiquitous alteration of choroid circulation causes localized retinal alterations in mice that are similar to human non-exudative age-related macular degeneration, thus providing a new potential experimental model of the disease.