Table 4.

Additional genetic models that mimic discreet pathophysiological aspects of diabetic cardiomyopathy

Mouse modelReferences
Defective insulin signaling
Dominant negative PI3KMcMullen et al., 2003
Heart and skeletal muscle PDK1 KOMora et al., 2003
Cardiomyocyte GLUT4 KOAbel et al., 1999
GLUT4 heterozygous KOStenbit et al., 1997
UCP-DTA mouseDuncan et al., 2007
Lipotoxicity
Adipose TG lipase (ATGL) KOHaemmerle et al., 2006
  • KO, knockout; PI3K, phosphoinositide 3-kinase; PDK1, 3-phosphoinositide-dependent protein kinase 1; UCP-DTA, uncoupling protein-diphtheria toxin A.