Summary of common cardiac abnormalities in obese and type 2 diabetic patients, and in animal models of obesity and type 2 diabetes
| Obese/diabetic patients | ob/ob | db/db | ZDF | |
|---|---|---|---|---|
| Diastolic function | ↓ | ↓ | ↓ | ↓ |
| LV mass | ↑ | ↑ | ↑ | ↑ |
| Cardiac efficiency | ↓ | ↓ | ↓ | = |
| Fatty acid oxidation | ↑ | ↑ | ↑ | ↑ |
| Lipid content | ↑ | ↑ | ↑ | ↑ |
| Mitochondrial energetics | ↓ | ↓ | ↓ | |
| Ca2+ handling | ↓ | ↓ | ↓ | = |
LV, left ventricular; ZDF, Zucker diabetic fatty.
See text for references.