Table 1.

Selected spindle factors implicated in cancer

FactorFunction in spindleAlteration in cancerReference
TPX2MT nucleation, spindle pole formationOverexpressed in tumorsTonon et al., 2005
MaskinStabilizes and anchors MT at poleDownregulated in a subset of breast cancersConte et al., 2003
HURPMT bundling, chromosome alignmentOverexpressed in tumorsHuang et al., 2003; Tsou et al., 2003; Wang et al., 2006
BRCA1/BARD1E3 ubiquitin ligase, spindle pole formationMutations in BRCA1 increase susceptibility to breast cancerClarke and Sanderson, 2006
Eg5Kinesin family motor, spindle bipolarity, MT fluxOverexpression can lead to tumor formation, target of cancer therapiesCastillo et al., 2007; Liu et al., 2008; Nakai et al., 2009; Rello-Varona et al., 2009
RHAMMMT nucleation, spindle pole formationOverexpressed in tumorsToole, 2004; Maxwell et al., 2008
SurvivinMember of CPCOverexpressed in tumorsAltieri et al., 2008a
SecurinCheckpoint, regulation of sister chromatid cohesionOverexpressed in tumors, especially pituitarySalehi et al., 2008
Mad1Spindle checkpoint, member of MCCOverexpressed in breast and lung tumors, downregulated in leukemiaYuan et al., 2006; Coe et al., 2006; Kasai et al., 2002
Mad2Spindle checkpoint, member of MCCMutated in gastric tumors, upregulated in breast tumorsKim et al., 2005; Yuan et al., 2006
Bub3Spindle checkpoint, member of MCCUpregulated in breast and gastric tumorsYuan et al., 2006; Grabsch et al., 2003
  • MT=microtubule.