Table 2.

Ebola virus infection in mice

DeficiencyMouse strainZEBOV (ad)(i.p.)ZEBOV (ad)(s.c.)ZEBOV (wt)(i.p.)ZEBOV (wt)(s.c.)
NoneBALB/c, C57BL/6+
Adaptive immune responseSCID++++
Rag-2++++
Nude++
Beige+
IFN-γ knockout+
TNF-α knockout+
Innate immune responseIFN-α/β-receptor knockout++++
STAT1 knockout++++
OtherLymphotoxin-α knockout++
  • +=lethal infection; −=no apparent disease; ad=adapted strain; i.p.=intraperitoneal; s.c.=subcutaneous; wt =wild-type strain [summarized from Bray (Bray, 2001)].