Table 1.

Infection in animal models and humans

Mouse (wt)Mouse (ad)*Guinea pig (wt)Guinea pig (ad)NHP (wt)Human (wt)
ViremiaLowHighLowHighHighHigh
VirulenceLowHighLowHighHighHigh
Primary cell tropismUnknownMPCUnknownMPCMPCMPC
Macular rushNoNoNoNoYesYes
Coagulation abnormalitiesNoNot profoundNoSomeYesYes
Liver enzymesUnknownElevatedUnknownElevatedElevatedElevated
ThrombocytopeniaUnknownYesUnknownYesYesYes
Lymphocyte apoptosisUnknownYesUnknownLimitedYesYes
Proinflammatory cytokine responseUnknownYesUnknownYesYesYes
  • MPC= mononuclear phagocytic cell; ad=adapted strain; wt=wild-type strain;

  • * Ebola virus only. [Table altered from Stroeher and Feldmann (Stroeher and Feldmann, 2006).]