PT  - JOURNAL ARTICLE
AU  - Liu, Elaine Y.
AU  - Cali, Christopher P.
AU  - Lee, Edward B.
TI  - RNA metabolism in neurodegenerative disease
AID  - 10.1242/dmm.028613
DP  - 2017 May 01
TA  - Disease Models & Mechanisms
PG  - 509--518
VI  - 10
IP  - 5
4099  - http://dmm.biologists.org/content/10/5/509.short
4100  - http://dmm.biologists.org/content/10/5/509.full
SO  - Dis Models Mech2017 May 01; 10
AB  - Aging-related neurodegenerative diseases are progressive and fatal neurological diseases that are characterized by irreversible neuron loss and gliosis. With a growing population of aging individuals, there is a pressing need to better understand the basic biology underlying these diseases. Although diverse disease mechanisms have been implicated in neurodegeneration, a common theme of altered RNA processing has emerged as a unifying contributing factor to neurodegenerative disease. RNA processing includes a series of distinct processes, including RNA splicing, transport and stability, as well as the biogenesis of non-coding RNAs. Here, we highlight how some of these mechanisms are altered in neurodegenerative disease, including the mislocalization of RNA-binding proteins and their sequestration induced by microsatellite repeats, microRNA biogenesis alterations and defective tRNA biogenesis, as well as changes to long-intergenic non-coding RNAs. We also highlight potential therapeutic interventions for each of these mechanisms.