PT - JOURNAL ARTICLE AU - Liu, Elaine Y. AU - Cali, Christopher P. AU - Lee, Edward B. TI - RNA metabolism in neurodegenerative disease AID - 10.1242/dmm.028613 DP - 2017 May 01 TA - Disease Models & Mechanisms PG - 509--518 VI - 10 IP - 5 4099 - http://dmm.biologists.org/content/10/5/509.short 4100 - http://dmm.biologists.org/content/10/5/509.full SO - Dis Models Mech2017 May 01; 10 AB - Aging-related neurodegenerative diseases are progressive and fatal neurological diseases that are characterized by irreversible neuron loss and gliosis. With a growing population of aging individuals, there is a pressing need to better understand the basic biology underlying these diseases. Although diverse disease mechanisms have been implicated in neurodegeneration, a common theme of altered RNA processing has emerged as a unifying contributing factor to neurodegenerative disease. RNA processing includes a series of distinct processes, including RNA splicing, transport and stability, as well as the biogenesis of non-coding RNAs. Here, we highlight how some of these mechanisms are altered in neurodegenerative disease, including the mislocalization of RNA-binding proteins and their sequestration induced by microsatellite repeats, microRNA biogenesis alterations and defective tRNA biogenesis, as well as changes to long-intergenic non-coding RNAs. We also highlight potential therapeutic interventions for each of these mechanisms.