RT Journal Article
SR Electronic
T1 Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models
JF Disease Models & Mechanisms
JO Dis Models Mech
FD The Company of Biologists Limited
SP 763
OP 771
DO 10.1242/dmm.008961
VO 5
IS 6
A1 Hu, Jinsong
A1 Van Valckenborgh, Els
A1 Menu, Eline
A1 De Bruyne, Elke
A1 Vanderkerken, Karin
YR 2012
UL http://dmm.biologists.org/content/5/6/763.abstract
AB Multiple myeloma (MM) is the second most common hematological malignancy and is characterized by the clonal expansion of plasma cells in the bone marrow. Recently, hypoxia has received increased interest in the context of MM, in both basic and translational research. In this review, we describe the discovery of the hypoxic niche in MM and how it can be targeted therapeutically. We also discuss mouse models that closely mimic human MM, highlighting those that allow preclinical research into new therapies that exploit the hypoxic niche in MM.