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Disease Models & Mechanisms

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Arx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome
Meagan S. Siehr, Cory A. Massey, Jeffrey L. Noebels

Disease Models & Mechanisms Mar 2020, 13 (3) dmm042515; DOI: 10.1242/dmm.042515
FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity
Gopinath Krishnamoorthy, Peggy Kaiser, Ulrike Abu Abed, January Weiner, Pedro Moura-Alves, Volker Brinkmann, Stefan H. E. Kaufmann

Disease Models & Mechanisms Mar 2020, 13 (3) dmm041954; DOI: 10.1242/dmm.041954
A murine model demonstrates capsule-independent adaptive immune protection in survivors of Klebsiella pneumoniae respiratory tract infection
Joy Twentyman, Catherine Morffy Smith, Julia S. Nims, Aubree A. Dahler, David A. Rosen

Disease Models & Mechanisms Mar 2020, 13 (3) dmm043240; DOI: 10.1242/dmm.043240
Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure
Marina R. Carpinelli, Michael E. de Vries, Alana Auden, Tariq Butt, Zihao Deng, Darren D. Partridge, Lee B. Miles, Smitha R. Georgy, Jody J. Haigh, Charbel Darido, Simone Brabletz, Thomas Brabletz, Marc P. Stemmler, Sebastian Dworkin, Stephen M. Jane

Disease Models & Mechanisms Mar 2020, 13 (3) dmm042218; DOI: 10.1242/dmm.042218
Accepted Manuscript
The transcription factor Nurr1 is up-regulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice
Valeria Valsecchi, Marina Boido, Francesca Montarolo, Michela Guglielmotto, Simona Perga, Serena Martire, Santina Cutrupi, Andrea Iannello, Nadia Gionchiglia, Elena Signorino, Andrea Calvo, Giuseppe Fuda, Adriano Chiò, Antonio Bertolotto, Alessandro Vercelli

Disease Models & Mechanisms Jan 2020, dmm.043513; DOI: 10.1242/dmm.043513
Accepted Manuscript
Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive (SS) but not Dahl salt-resistant (SR) rats
Eunjo Lee, Namkyung Kim, Jinjoo Kang, Sangwon Yoon, Hae-Ahm Lee, Hanna Jung, Sang-Hyun Kim, Inkyeom Kim

Disease Models & Mechanisms Jan 2020, dmm.044107; DOI: 10.1242/dmm.044107
Genetic background modifies phenotypic severity and longevity in a mouse model of Niemann-Pick disease type C1
Jorge L. Rodriguez-Gil, Dawn E. Watkins-Chow, Laura L. Baxter, Gene Elliot, Ursula L. Harper, Stephen M. Wincovitch, Julia C. Wedel, Arturo A. Incao, Mylene Huebecker, Frederick J. Boehm, William S. Garver, Forbes D. Porter, Karl W. Broman, Frances M. Platt, William J. Pavan

Disease Models & Mechanisms Mar 2020, 13 (3) dmm042614; DOI: 10.1242/dmm.042614
Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells
Carina Lund, Venkatram Yellapragada, Sanna Vuoristo, Diego Balboa, Sara Trova, Cecile Allet, Nazli Eskici, Kristiina Pulli, Paolo Giacobini, Timo Tuuri, Taneli Raivio

Disease Models & Mechanisms Mar 2020, 13 (3) dmm040105; DOI: 10.1242/dmm.040105
Accepted Manuscript
Zika virus non-structural protein NS4A restricts eye growth in Drosophila through regulation of JAK/STAT signaling
Sneh Harsh, Yulong Fu, Eric Kenney, Zhe Han, Ioannis Eleftherianos

Disease Models & Mechanisms Jan 2020, dmm.040816; DOI: 10.1242/dmm.040816
Accepted Manuscript
Deterioration of muscle force and contractile characteristics are early pathological events in spinal and bulbar muscular atrophy mice
Anna L. Gray, Leonette Annan, James R. T. Dick, Albert R. La Spada, Michael G. Hanna, Linda Greensmith, Bilal Malik

Disease Models & Mechanisms Jan 2020, dmm.042424; DOI: 10.1242/dmm.042424

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Disease Models & Mechanisms

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