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RESEARCH ARTICLE
A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies
Oriol Calvete, Andrea Varro, D. Mark Pritchard, Alicia Barroso, Marta Oteo, Miguel Ángel Morcillo, Pierfrancesco Vargiu, Steven Dodd, Miriam Garcia, José Reyes, Sagrario Ortega, Javier Benitez
Disease Models & Mechanisms 2016 9: 975-984; doi: 10.1242/dmm.025890
Oriol Calvete
1Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
2Spanish Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid 28029, Spain
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  • ORCID record for Oriol Calvete
Andrea Varro
3Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK
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D. Mark Pritchard
3Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK
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Alicia Barroso
1Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
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Marta Oteo
4Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid 28040, Spain
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Miguel Ángel Morcillo
4Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid 28040, Spain
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Pierfrancesco Vargiu
5Transgenic Mice Core Unit, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
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Steven Dodd
3Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK
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Miriam Garcia
6Animal Facility Core Unit, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
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José Reyes
7Department of Gastroenterology, Hospital INCA, Majorca 07300, Spain
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Sagrario Ortega
5Transgenic Mice Core Unit, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
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  • For correspondence: sortega@cnio.es jbenitez@cnio.es
Javier Benitez
1Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
2Spanish Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid 28029, Spain
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  • For correspondence: sortega@cnio.es jbenitez@cnio.es
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Article Information

vol. 9 no. 9, 975-984

DOI 
https://doi.org/10.1242/dmm.025890
PubMed 
27491072

Published By 
The Company of Biologists Ltd
Print ISSN 
1754-8403
Online ISSN 
1754-8411
History 
  • Received April 13, 2016
  • Accepted July 12, 2016
  • Published online September 7, 2016.
Posted online 
August 04, 2016
Copyright & Usage 
© 2016. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Article Versions

  • Previous version (August 4, 2016 - 02:57).
  • You are viewing the most recent version of this article.

Author Information

  1. Oriol Calvete1,2,
  2. Andrea Varro3,
  3. D. Mark Pritchard3,
  4. Alicia Barroso1,
  5. Marta Oteo4,
  6. Miguel Ángel Morcillo4,
  7. Pierfrancesco Vargiu5,
  8. Steven Dodd3,
  9. Miriam Garcia6,
  10. José Reyes7,
  11. Sagrario Ortega5,* and
  12. Javier Benitez1,2,*
  1. 1Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
  2. 2Spanish Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid 28029, Spain
  3. 3Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK
  4. 4Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid 28040, Spain
  5. 5Transgenic Mice Core Unit, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
  6. 6Animal Facility Core Unit, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
  7. 7Department of Gastroenterology, Hospital INCA, Majorca 07300, Spain
  1. ↵*Authors for correspondence (sortega{at}cnio.es; jbenitez{at}cnio.es)
View Abstract

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Keywords

  • ATP4a
  • Gastric carcinoids
  • Achlorhydria
  • Hypergastrinemia
  • Oxyntic glands

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RESEARCH ARTICLE
A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies
Oriol Calvete, Andrea Varro, D. Mark Pritchard, Alicia Barroso, Marta Oteo, Miguel Ángel Morcillo, Pierfrancesco Vargiu, Steven Dodd, Miriam Garcia, José Reyes, Sagrario Ortega, Javier Benitez
Disease Models & Mechanisms 2016 9: 975-984; doi: 10.1242/dmm.025890
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RESEARCH ARTICLE
A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies
Oriol Calvete, Andrea Varro, D. Mark Pritchard, Alicia Barroso, Marta Oteo, Miguel Ángel Morcillo, Pierfrancesco Vargiu, Steven Dodd, Miriam Garcia, José Reyes, Sagrario Ortega, Javier Benitez
Disease Models & Mechanisms 2016 9: 975-984; doi: 10.1242/dmm.025890

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