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  Open access

December, 2016; 9 (12)

REVIEW

  • Open Access
    Renal disease pathophysiology and treatment: contributions from the rat
    Linda J. Mullins, Bryan R. Conway, Robert I. Menzies, Laura Denby, John J. Mullins
    Disease Models & Mechanisms 2016 9: 1419-1433; doi: 10.1242/dmm.027276

    Summary: This Review highlights the key role that the rat continues to play in improving our understanding of the etiologies of renal pathologies, and how these insights have opened up new therapeutic avenues.

RESEARCH ARTICLES

  • Open Access
    Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior
    Milcah C. Scott, Hirotaka Tomiyasu, John R. Garbe, Ingrid Cornax, Clarissa Amaya, M. Gerard O'Sullivan, Subbaya Subramanian, Brad A. Bryan, Jaime F. Modiano
    Disease Models & Mechanisms 2016 9: 1435-1444; doi: 10.1242/dmm.026849

    Editors' choice: We developed a system that recapitulates the heterogeneous biological behavior of bone cancer in mouse models and describe novel methods to study tumor–stromal interactions in these models.

  • Open Access
    Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping
    Dayna L. Dreger, Maud Rimbault, Brian W. Davis, Adrienne Bhatnagar, Heidi G. Parker, Elaine A. Ostrander
    Disease Models & Mechanisms 2016 9: 1445-1460; doi: 10.1242/dmm.027037

    Summary: Successful application of whole-genome sequencing and genome-wide association studies for identifying both loci and mutations in canines is influenced by breed structure and demography, motivating researchers to generate breed-specific strategies for canine genetic studies.

  • Open Access
    Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models
    María Virtudes Céspedes, María José Guillén, Pedro Pablo López-Casas, Francesca Sarno, Alberto Gallardo, Patricia Álamo, Carmen Cuevas, Manuel Hidalgo, Carlos María Galmarini, Paola Allavena, Pablo Avilés, Ramón Mangues
    Disease Models & Mechanisms 2016 9: 1461-1471; doi: 10.1242/dmm.026369

    Summary: Lurbinectedin-gemcitabine synergism in PDA models involves lurbinectedin-induced tumor macrophage depletion, triggering CDA downregulation and enhanced DNA damage, supporting the use of this combination to treat macrophage-infiltrated pancreatic tumors.

  • Open Access
    Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521
    Masayuki Nakano, Kinnosuke Yahiro, Eiki Yamasaki, Hisao Kurazono, Junko Akada, Yoshio Yamaoka, Takuro Niidome, Masanori Hatakeyama, Hidekazu Suzuki, Taro Yamamoto, Joel Moss, Hajime Isomoto, Toshiya Hirayama
    Disease Models & Mechanisms 2016 9: 1473-1481; doi: 10.1242/dmm.025361

    Summary: The authors show a newly identified role of VacA in Helicobacter pylori infection through induction of tyrosine phosphorylation of CagA acting through the VacA receptor RPTPα.

  • Open Access
    Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice
    Veronica S. Gil, Govind Bhagat, Louise Howell, Jiyuan Zhang, Chae H. Kim, Sven Stengel, Francisco Vega, Arthur Zelent, Kevin Petrie
    Disease Models & Mechanisms 2016 9: 1483-1495; doi: 10.1242/dmm.023366

    Summary: This study demonstrates that aberrant expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma through altering expression of genes involved in the cell cycle and survival, and modulating the activity of key B-lineage factors such as BCL6 and p53.

  • Open Access
    Microglia activation in a pediatric rabbit model of tuberculous meningitis
    Elizabeth W. Tucker, Supriya Pokkali, Zhi Zhang, Vincent P. DeMarco, Mariah Klunk, Elizabeth S. Smith, Alvaro A. Ordonez, Marie-France Penet, Zaver Bhujwalla, Sanjay K. Jain, Sujatha Kannan
    Disease Models & Mechanisms 2016 9: 1497-1506; doi: 10.1242/dmm.027326

    Summary: A clinically relevant novel rabbit model provides robust microglial activation and neurological deficits as seen in children with pediatric central nervous system tuberculosis.

  • Open Access
    Recovery of erectile function comparing autologous nerve grafts, unseeded conduits, Schwann-cell-seeded guidance tubes and GDNF-overexpressing Schwann cell grafts
    Florian May, Alexander Buchner, Kaspar Matiasek, Boris Schlenker, Christian Stief, Norbert Weidner
    Disease Models & Mechanisms 2016 9: 1507-1511; doi: 10.1242/dmm.026518

    Summary: Schwann-cell-seeded scaffolds and GDNF-overexpressing Schwann cell grafts are superior to unseeded tubes and autologous nerve grafts for the repair of erectile nerve gaps following nerve excision in rats.

RETRACTION

  • Open Access
    Retraction: The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis
    Minsi Zhang, David G. Kirsch
    Disease Models & Mechanisms 2016 9: 1513 doi: 10.1242/dmm.028340
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  • Open Access

    Metabolomics and lipidomics in C. elegans using a single sample preparation

    Marte Molenaars, Bauke V. Schomakers, Hyung L. Elfrink, Arwen W. Gao, Martin A. T. Vervaart, Mia L. Pras-Raves, Angela C. Luyf, Reuben L. Smith, Mark G. Sterken, Jan E. Kammenga, Antoine H. C. van Kampen, Georges E. Janssens, Frédéric M. Vaz, Michel van Weeghel, Riekelt H. Houtkooper
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  • Open Access

    High dimensional immunotyping of tumors grown in obese and non-obese mice

    Cara E. Wogsland, Hilde E. Lien, Line Pedersen, Pahul Hanjra, Sturla M. Grondal, Rolf A. Brekken, James B. Lorens, Nils Halberg
    PDF
  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
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Perspective - Modelling the developmental origins of paediatric cancer to improve patient outcomes

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A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities

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