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RESEARCH ARTICLE
Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis
Tim S. Ellison, Samuel J. Atkinson, Veronica Steri, Benjamin M. Kirkup, Michael E. J. Preedy, Robert T. Johnson, Christiana Ruhrberg, Dylan R. Edwards, Jochen G. Schneider, Katherine Weilbaecher, Stephen D. Robinson
Disease Models & Mechanisms 2015 8: 1105-1119; doi: 10.1242/dmm.019927
Tim S. Ellison
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
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Samuel J. Atkinson
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
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Veronica Steri
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
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Benjamin M. Kirkup
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
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Michael E. J. Preedy
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
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Robert T. Johnson
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
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Christiana Ruhrberg
Institute of Ophthalmology, University College London, London, EC1V 9EL, UK
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Dylan R. Edwards
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
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Jochen G. Schneider
Luxembourg Center for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg & Saarland University Medical Center, Internal Medicine II, L-4362 Homburg, Germany
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Katherine Weilbaecher
Department of Internal Medicine, Division of Molecular Oncology, Washington University in St Louis, St Louis, MO 63110, USA
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Stephen D. Robinson
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
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  • For correspondence: stephen.robinson@uea.ac.uk
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Article Information

vol. 8 no. 9, 1105-1119

DOI 
https://doi.org/10.1242/dmm.019927
PubMed 
26159543

Published By 
The Company of Biologists Ltd
Print ISSN 
1754-8403
Online ISSN 
1754-8411
History 
  • Received January 13, 2015
  • Accepted July 7, 2015
  • Published online August 27, 2015.
Posted online 
July 09, 2015
Copyright & Usage 
© 2015. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Article Versions

  • Previous version (July 9, 2015 - 07:20).
  • Previous version (July 10, 2015 - 00:24).
  • You are viewing the most recent version of this article.

Author Information

  1. Tim S. Ellison1,
  2. Samuel J. Atkinson1,
  3. Veronica Steri1,
  4. Benjamin M. Kirkup1,
  5. Michael E. J. Preedy1,
  6. Robert T. Johnson1,
  7. Christiana Ruhrberg2,
  8. Dylan R. Edwards1,
  9. Jochen G. Schneider3,
  10. Katherine Weilbaecher4 and
  11. Stephen D. Robinson1,*
  1. 1School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
  2. 2Institute of Ophthalmology, University College London, London, EC1V 9EL, UK
  3. 3Luxembourg Center for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg & Saarland University Medical Center, Internal Medicine II, L-4362 Homburg, Germany
  4. 4Department of Internal Medicine, Division of Molecular Oncology, Washington University in St Louis, St Louis, MO 63110, USA
  1. ↵*Author for correspondence (stephen.robinson{at}uea.ac.uk)
View Abstract

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Total131418361737

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Keywords

  • Integrin
  • Neuropilin-1
  • Angiogenesis
  • Tumour
  • Focal adhesion

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RESEARCH ARTICLE
Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis
Tim S. Ellison, Samuel J. Atkinson, Veronica Steri, Benjamin M. Kirkup, Michael E. J. Preedy, Robert T. Johnson, Christiana Ruhrberg, Dylan R. Edwards, Jochen G. Schneider, Katherine Weilbaecher, Stephen D. Robinson
Disease Models & Mechanisms 2015 8: 1105-1119; doi: 10.1242/dmm.019927
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RESEARCH ARTICLE
Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis
Tim S. Ellison, Samuel J. Atkinson, Veronica Steri, Benjamin M. Kirkup, Michael E. J. Preedy, Robert T. Johnson, Christiana Ruhrberg, Dylan R. Edwards, Jochen G. Schneider, Katherine Weilbaecher, Stephen D. Robinson
Disease Models & Mechanisms 2015 8: 1105-1119; doi: 10.1242/dmm.019927

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