Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Disease Models & Mechanisms
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Disease Models & Mechanisms

Advanced search

RSS   Twitter   Facebook   YouTube

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback

 

  You have access

  Open access

August, 2015; 8 (8)

IN THIS ISSUE

  • Open Access
    apoc2-mutant zebrafish to study hypertriglyceridemia
    Disease Models & Mechanisms 2015 8: e0801
  • Open Access
    A link between impaired intestinal permeability and inflammatory intestinal disease
    Disease Models & Mechanisms 2015 8: e0802
  • Open Access
    A reversible state of heart dysfunction treatable by RAS inhibition
    Disease Models & Mechanisms 2015 8: e0803

EDITORIAL

  • Open Access
    Embracing risk
    Ross Cagan
    Disease Models & Mechanisms 2015 8: 767 doi: 10.1242/dmm.021840

    Summary: We are entering an era of unprecedented promise for solving some of humankind's most pressing health issues. In this Editorial, Ross Cagan emphasizes the importance of taking risks in science and in career choices.

REVIEW

  • Open Access
    RASopathies: unraveling mechanisms with animal models
    Granton A. Jindal, Yogesh Goyal, Rebecca D. Burdine, Katherine A. Rauen, Stanislav Y. Shvartsman
    Disease Models & Mechanisms 2015 8: 769-782; doi: 10.1242/dmm.020339

    Summary: Developmental disorders caused by germline mutations in the Ras-MAPK pathway are called RASopathies. Studies with animal models, including mice, zebrafish and Drosophila, continue to enhance our understanding of these diseases.

RESEARCH ARTICLES

  • Open Access
    A state of reversible compensated ventricular dysfunction precedes pathological remodelling in response to cardiomyocyte-specific activity of angiotensin II type-1 receptor in mice
    Georgia A. Frentzou, Mark J. Drinkhill, Neil A. Turner, Stephen G. Ball, Justin F. X. Ainscough
    Disease Models & Mechanisms 2015 8: 783-794; doi: 10.1242/dmm.019174

    Highlighted Article: A novel conditional mouse model was used to investigate early initiating stages of heart disease that are commonly overlooked, and identifies a ‘window of opportunity’ for personalised therapeutic intervention.

  • Open Access
    Tomoregulin-1 prevents cardiac hypertrophy after pressure overload in mice by inhibiting TAK1-JNK pathways
    Dan Bao, Dan Lu, Ning Liu, Wei Dong, Ying-Dong Lu, Chuan Qin, Lian-Feng Zhang
    Disease Models & Mechanisms 2015 8: 795-804; doi: 10.1242/dmm.021303

    Summary: Tomoregulin-1 is primarily involved in embryonic development and adult CNS function. To the authors' knowledge, this is the first study about the function of tomoregulin-1 on cardiac hypertrophy in mice.

  • Open Access
    Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease
    Benjamin B. Williams, Niall C. Tebbutt, Michael Buchert, Tracy L. Putoczki, Karen Doggett, Shisan Bao, Cameron N. Johnstone, Frederick Masson, Frederic Hollande, Antony W. Burgess, Andrew M. Scott, Matthias Ernst, Joan K. Heath
    Disease Models & Mechanisms 2015 8: 805-815; doi: 10.1242/dmm.019935

    Highlighted Article: We show that GPA33, an intestine-specific cell surface protein, plays a role in the maintenance of intestinal barrier function and the prevention of intestinal pathologies such as food hypersensitivity, inflammatory bowel disease and colitis-associated cancer.

  • Open Access
    Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis
    Thean S. Chew, Nuala R. O'Shea, Gavin W. Sewell, Stefan H. Oehlers, Claire M. Mulvey, Philip S. Crosier, Jasminka Godovac-Zimmermann, Stuart L. Bloom, Andrew M. Smith, Anthony W. Segal
    Disease Models & Mechanisms 2015 8: 817-829; doi: 10.1242/dmm.020362

    Summary: Optineurin plays a role in acute inflammation, proinflammatory cytokine secretion and neutrophil recruitment, which suggests that diminished optineurin expression in humans might increase the risk of developing Crohn's disease.

  • Open Access
    A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis
    Xiaohua Xu, Aleksandar Denic, Luke R. Jordan, Nathan J. Wittenberg, Arthur E. Warrington, Bharath Wootla, Louisa M. Papke, Laurie J. Zoecklein, Daehan Yoo, Jonah Shaver, Sang-Hyun Oh, Larry R. Pease, Moses Rodriguez
    Disease Models & Mechanisms 2015 8: 831-842; doi: 10.1242/dmm.020727

    Summary: A single peripheral dose of a recombinant natural human IgM increases lifespan and delays neurological deficits in mouse models of human ALS.

  • Open Access
    A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase
    Marissa A. Holmbeck, Julia R. Donner, Eugenia Villa-Cuesta, David M. Rand
    Disease Models & Mechanisms 2015 8: 843-854; doi: 10.1242/dmm.019323

    Summary: Interacting mutations in a mitochondrially encoded tRNA and nuclear-encoded tRNA synthetase result in a suite of pathologies, including altered locomotor capacity, mitochondrial function and morphology, and mitochondrial translation.

  • Open Access
    Using the avian mutant talpid2 as a disease model for understanding the oral-facial phenotypes of oral-facial-digital syndrome
    Elizabeth N. Schock, Ching-Fang Chang, Jaime N. Struve, Ya-Ting Chang, Julie Chang, Mary E. Delany, Samantha A. Brugmann
    Disease Models & Mechanisms 2015 8: 855-866; doi: 10.1242/dmm.020222

    Summary: This study utilizes a naturally occurring avian mutant known as talpid2 to determine the cellular basis for the oral-facial phenotypes present in oral-facial-digital syndrome.

  • Open Access
    MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma
    Mohit Sachdeva, Melody J. Whitley, Jeffrey K. Mito, Yan Ma, Dina C. Lev, Diana M. Cardona, David G. Kirsch
    Disease Models & Mechanisms 2015 8: 867-875; doi: 10.1242/dmm.017897

    Summary: This work underscores the importance of studying cancer metastasis using in vivo model systems in addition to in vitro and transplant model systems.

  • Open Access
    Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells
    Kathrin Mutze, Sarah Vierkotten, Jadranka Milosevic, Oliver Eickelberg, Melanie Königshoff
    Disease Models & Mechanisms 2015 8: 877-890; doi: 10.1242/dmm.019117

    Summary: The authors identified proteins involved in Wnt/β-catenin-driven alveolar epithelial plasticity in lung injury and repair.

  • Open Access
    Effects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast
    Jing Bi, Robert T. Carroll, Michael L. James, Jessica L. Ouderkirk, Mira Krendel, Vladimir Sirotkin
    Disease Models & Mechanisms 2015 8: 891-902; doi: 10.1242/dmm.020214

    Summary: In the fission yeast S. pombe, kidney disease-associated mutations in Myo1, a homolog of human Myo1e, disrupt myosin localization and function.

  • Open Access
    Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice
    Rachel L. Berry, Derya D. Ozdemir, Bruce Aronow, Nils O. Lindström, Tatiana Dudnakova, Anna Thornburn, Paul Perry, Richard Baldock, Chris Armit, Anagha Joshi, Cécile Jeanpierre, Jingdong Shan, Seppo Vainio, James Baily, David Brownstein, Jamie Davies, Nicholas D. Hastie, Peter Hohenstein
    Disease Models & Mechanisms 2015 8: 903-917; doi: 10.1242/dmm.018523

    Summary: The comparison of different nephron-specific Wt1-knockout mouse models identifies the stage of origin of human WT1-mutant Wilms' tumours.

  • Open Access
    Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats
    Saleh Yazdani, Ryanne S. Hijmans, Fariba Poosti, Wendy Dam, Gerjan Navis, Harry van Goor, Jacob van den Born
    Disease Models & Mechanisms 2015 8: 919-930; doi: 10.1242/dmm.018580

    Summary: Targeting lymphangiogenesis, inflammation or fibrosis separately in a rat model of proteinuric nephropathy showed that treating any of these changes alone is not effective in treating the disease.

  • Open Access
    Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice
    Shailendra P. Singh, Shixin Tao, Timothy A. Fields, Sydney Webb, Raymond C. Harris, Reena Rao
    Disease Models & Mechanisms 2015 8: 931-940; doi: 10.1242/dmm.020511

    Summary: GSK3 promotes renal fibrosis by activation of TGF-β signaling, and the use of GSK3 inhibitors might represent a novel therapeutic approach for progressive renal fibrosis that develops as a consequence of acute kidney injury.

  • Open Access
    Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome
    Stefanie M. Percival, Holly R. Thomas, Adam Amsterdam, Andrew J. Carroll, Jacqueline A. Lees, H. Joseph Yost, John M. Parant
    Disease Models & Mechanisms 2015 8: 941-955; doi: 10.1242/dmm.019059

    Summary: In vivo analysis of zebrafish esco2 mutants reveals extensive genomic instability and activation of DNA-damage-response pathways, although some cells have compensatory cohesion and divide normally.

  • Open Access
    Sun1 deficiency leads to cerebellar ataxia in mice
    Jing-Ya Wang, I.-Shing Yu, Chien-Chi Huang, Chia-Yen Chen, Wan-Ping Wang, Shu-Wha Lin, Kuan-Teh Jeang, Ya-Hui Chi
    Disease Models & Mechanisms 2015 8: 957-967; doi: 10.1242/dmm.019240

    Summary: Mice lacking Sun proteins serve as a working model to study SYNE1-associated cerebellar ataxia; they will also be useful in identifying therapeutic targets for neurodegenerative diseases involving Purkinje cell loss.

  • Open Access
    Phenotypic and functional characterization of Bst+/− mouse retina
    Hamidreza Riazifar, Guoli Sun, Xinjian Wang, Alan Rupp, Shruti Vemaraju, Fred N. Ross-Cisneros, Richard A. Lang, Alfredo A. Sadun, Samer Hattar, Min-Xin Guan, Taosheng Huang
    Disease Models & Mechanisms 2015 8: 969-976; doi: 10.1242/dmm.018176

    Summary: We characterized Bst+/− mice and found that pupillary light reflex was completely absent, which could be used as a readout for the efficacy of stem cell therapy in this model.

  • Open Access
    Ethambutol induces impaired autophagic flux and apoptosis in the rat retina
    Shun-Ping Huang, Jia-Ying Chien, Rong-Kung Tsai
    Disease Models & Mechanisms 2015 8: 977-987; doi: 10.1242/dmm.019737

    Summary: This study provides the first evidence that EMB induces autophagosome accumulation, which results from the impaired autophagic flux that is mediated by a PKCδ-dependent pathway, and leads to apoptotic death in retina neuronal cells.

RESOURCE ARTICLES

  • Open Access
    Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia
    Chao Liu, Keith P. Gates, Longhou Fang, Marcelo J. Amar, Dina A. Schneider, Honglian Geng, Wei Huang, Jungsu Kim, Jennifer Pattison, Jian Zhang, Joseph L. Witztum, Alan T. Remaley, P. Duc Dong, Yury I. Miller
    Disease Models & Mechanisms 2015 8: 989-998; doi: 10.1242/dmm.019836

    Highlighted Article: Apoc2 loss-of-function zebrafish display severe hypertriglyceridemia, which is characteristic of human patients with defective lipoprotein lipase activity.

  • Open Access
    Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype
    Val A. Fajardo, Eric Bombardier, Elliott McMillan, Khanh Tran, Brennan J. Wadsworth, Daniel Gamu, Andrew Hopf, Chris Vigna, Ian C. Smith, Catherine Bellissimo, Robin N. Michel, Mark A. Tarnopolsky, Joe Quadrilatero, A. Russell Tupling
    Disease Models & Mechanisms 2015 8: 999-1009; doi: 10.1242/dmm.020859

    Summary: Phospholamban overexpression in mouse slow-twitch muscle impairs SERCA function and causes histopathological features associated with human centronuclear myopathy.

Back to top
PreviousNext
Previous IssueNext Issue

This issue

Disease Models & Mechanisms: 8 (8)
  • Table of Contents (PDF)
  • About the Cover
  • Table of Contents
  • Index by author
  • Issue info (PDF)

RSSRSS Icon

JUMP TO

  • IN THIS ISSUE
  • EDITORIAL
  • REVIEW
  • RESEARCH ARTICLES
  • RESOURCE ARTICLES

  Alert me to new issues of Disease Models & Mechanisms

  • Accepted manuscripts
  • Most-read
Loading
  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
  • Open Access

    Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

    Paco López-Cuevas, Luke Deane, Yushi Yang, Chrissy L Hammond, Erika Kague
    PDF
  • Open Access

    Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

    Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
    PDF
See more accepted manuscripts...

Other journals from The Company of Biologists

Development

Journal of Cell Science

Journal of Experimental Biology

Biology Open

Advertisement

DMM and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.


Monica Justice bids farewell to DMM

In her farewell Editorial, outgoing Editor-in-Chief Monica Justice reminds us of the past half-decade of growth and of DMM's commitment to support the disease modelling community, concluding, “The knowledge and experience I gained during my time as Senior Editor and EiC at DMM is invaluable: working within a not-for-profit community publishing environment is a joy.”


3D imaging of beta cell mass in diabetic mouse models

In their inducible mouse model of diabetes, Roostalu et al. demonstrate how quantitative light-sheet imaging can capture changes in individual islets to help pharmacological research in diabetes.

Visit our YouTube channel to watch more videos from DMM, our sister journals and the Company.


Modelling Joubert syndrome patient-derived mutations in C. elegans

In this issue’s Editor’s choice, Karen Lange and colleagues used C. elegans to model and characterise two patient-derived mutations that cause the ciliopathy Joubert syndrome.


Interview – Karen Lange

First author of our current Editor’s choice, Karen Lange takes us behind the scenes of the paper, and shares her thoughts on how the lack of both time and job security will impact her research.

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Subject collections
  • Interviews
  • Sign up for alerts

About us

  • About DMM
  • Editors and Board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact DMM
  • Advertising
  • Feedback

Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992