ABSTRACT
Adipogenesis is accompanied by differentiation of adipose tissue-derived stem cells to adipocytes. As part of this differentiation, biogenesis of the oxidative phosphorylation system occurs. Many chemical compounds used in medicine, agriculture or other human activities affect oxidative phosphorylation function. Therefore, these xenobiotics could alter adipogenesis. We have analyzed the effects on adipocyte differentiation of some xenobiotics that act on the oxidative phosphorylation system. The tested concentrations have been previously reported in human blood. Our results show that pharmaceutical drugs that decrease mitochondrial DNA replication, such as nucleoside reverse transcriptase inhibitors, or inhibitors of mitochondrial protein synthesis, such as ribosomal antibiotics, diminish adipocyte differentiation and leptin secretion. By contrast, the environmental chemical pollutant tributyltin chloride, which inhibits the ATP synthase of the oxidative phosphorylation system, can promote adipocyte differentiation and leptin secretion, leading to obesity and metabolic syndrome as postulated by the obesogen hypothesis.
Footnotes
Competing interests
The authors declare no competing or financial interests.
Author contributions
L.L., J.M.T., E.R.-P. and E.L.-G. conceived and designed the experiments. L.L. and J.M.T. executed experiments. L.L., J.M.T., E.R.-P. and E.L.-G. analyzed and interpreted the data. L.L., J.M.T., J.M., E.R.-P. and E.L.-G. contributed to manuscript editing by thoroughly revising the manuscript and providing critical and intellectual suggestions. J.M. and E.R.-P. wrote the manuscript.
Funding
This work was supported by grants from the Instituto Aragonés de Ciencias de la Salud (PIPAMER 09-01 and 10-010); the Instituto de Salud Carlos III (FIS-PI14/00005 and PI14/00070); Departamento de Ciencia, Tecnología y Universidad del Gobierno de Aragón y Fondo Social Europeo (Grupos Consolidados B33) and FEDER Funding Program from the European Union. CIBERER is an initiative of the ISCIII.
Supplementary information
Supplementary information available online at http://dmm.biologists.org/lookup/suppl/doi:10.1242/dmm.021774/-/DC1
- Received June 1, 2015.
- Accepted September 3, 2015.
- © 2015. Published by The Company of Biologists Ltd
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
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