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RESEARCH ARTICLE
Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
Disease Models & Mechanisms 2015 8: 1427-1439; doi: 10.1242/dmm.019695
María González-Núñez
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
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Adela S. Riolobos
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
4Instituto de Neurociencias de Castilla y León (INCYL), Salamanca 37008, Spain
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Orlando Castellano
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
4Instituto de Neurociencias de Castilla y León (INCYL), Salamanca 37008, Spain
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Isabel Fuentes-Calvo
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
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María de los Ángeles Sevilla
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
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Bárbara Oujo
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
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Miguel Pericacho
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
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Ignacio Cruz-Gonzalez
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
5Departamento de Cardiología, Hospital Universitario de Salamanca, Salamanca 37007, Spain
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Fernando Pérez-Barriocanal
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
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Peter ten Dijke
6Department of Molecular Cell Biology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands
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Jose M. López-Novoa
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
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  • For correspondence: jmlnovoa@usal.es
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Keywords

  • Activin receptor-like kinase 1
  • Animal model of human disease
  • Angiotensin II
  • Arterial pressure
  • Catecholamines
  • Intracerebroventricular injection
  • Nitric oxide
  • Sympathetic nervous system

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RESEARCH ARTICLE
Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
Disease Models & Mechanisms 2015 8: 1427-1439; doi: 10.1242/dmm.019695
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RESEARCH ARTICLE
Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
Disease Models & Mechanisms 2015 8: 1427-1439; doi: 10.1242/dmm.019695

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