Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Disease Models & Mechanisms
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Disease Models & Mechanisms

Advanced search

RSS   Twitter   Facebook   YouTube

  • Home
  • Articles
    • Accepted manuscripts
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback
RESEARCH ARTICLE
Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
Disease Models & Mechanisms 2015 8: 1427-1439; doi: 10.1242/dmm.019695
María González-Núñez
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adela S. Riolobos
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
4Instituto de Neurociencias de Castilla y León (INCYL), Salamanca 37008, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Orlando Castellano
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
4Instituto de Neurociencias de Castilla y León (INCYL), Salamanca 37008, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Isabel Fuentes-Calvo
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
María de los Ángeles Sevilla
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bárbara Oujo
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Miguel Pericacho
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ignacio Cruz-Gonzalez
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
5Departamento de Cardiología, Hospital Universitario de Salamanca, Salamanca 37007, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fernando Pérez-Barriocanal
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter ten Dijke
6Department of Molecular Cell Biology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jose M. López-Novoa
1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: jmlnovoa@usal.es
  • Article
  • Figures & tables
  • Supp info
  • Info & metrics
  • PDF + SI
  • PDF
Loading

Article Information

vol. 8 no. 11, 1427-1439

DOI 
https://doi.org/10.1242/dmm.019695
PubMed 
26398936

Published By 
The Company of Biologists Ltd
Print ISSN 
1754-8403
Online ISSN 
1754-8411
History 
  • Received December 22, 2014
  • Accepted August 27, 2015
  • Published online October 28, 2015.
Copyright & Usage 
© 2015. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.


Author Information

  1. María González-Núñez1,2,3,
  2. Adela S. Riolobos1,3,4,
  3. Orlando Castellano3,4,
  4. Isabel Fuentes-Calvo1,2,3,
  5. María de los Ángeles Sevilla1,
  6. Bárbara Oujo1,2,3,
  7. Miguel Pericacho1,2,3,
  8. Ignacio Cruz-Gonzalez3,5,
  9. Fernando Pérez-Barriocanal1,2,3,
  10. Peter ten Dijke6 and
  11. Jose M. López-Novoa1,2,3,*
  1. 1Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca 37007, Spain
  2. 2Unidad de Fisiopatología Renal y Cardiovascular, Instituto ‘Reina Sofía’ de Investigación Nefrológica, Salamanca 37007, Spain
  3. 3Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, Spain
  4. 4Instituto de Neurociencias de Castilla y León (INCYL), Salamanca 37008, Spain
  5. 5Departamento de Cardiología, Hospital Universitario de Salamanca, Salamanca 37007, Spain
  6. 6Department of Molecular Cell Biology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands
  1. ↵*Author for correspondence (jmlnovoa{at}usal.es)

Article usage

Usage statistics are calculated at the beginning of each month for the previous month.

Usage statistics: September 2015 to January 2021

AbstractFullPdf
Sep 2015133147
Oct 2015822737
Nov 20156712341
Dec 2015204134
Total 2015302192159
Jan 20163114341
Feb 20162315126
Mar 201692018
Apr 2016142723
May 2016104632
Jun 2016107939
Jul 201652629
Aug 2016114221
Sep 201693722
Oct 20165339
Nov 20163369
Dec 201664923
Total 2016136689292
Jan 20173287
Feb 20170326
Mar 20172269
Apr 201732714
May 201716016
Jun 201726415
Jul 201747314
Aug 201744514
Sep 201746925
Oct 2017719813
Nov 201731188
Dec 2017315812
Total 201736898153
Jan 201811049
Feb 20187569
Mar 201810719
Apr 201888911
May 2018106717
Jun 201896219
Jul 201894916
Aug 201833310
Sep 20184399
Oct 201818812
Nov 2018514417
Dec 201841427
Total 201871944145
Jan 201921262
Feb 201931129
Mar 201905516
Apr 201906214
May 201923616
Jun 201903215
Jul 201902111
Aug 20196119
Sep 201911614
Oct 201913011
Nov 201924511
Dec 201913011
Total 201918576139
Jan 202042611
Feb 20200148
Mar 20203127
Apr 20200124
May 202012618
Jun 20201316
Jul 20203383
Aug 202001516
Sep 20203109
Oct 202042929
Nov 202021719
Dec 20204818
Total 202025238148
Jan 202121215
Total 202121215
Total59035491051

Statistics from Altmetric.com

Previous ArticleNext Article
Back to top
Previous ArticleNext Article

This Issue

RSSRSS

Keywords

  • Activin receptor-like kinase 1
  • Animal model of human disease
  • Angiotensin II
  • Arterial pressure
  • Catecholamines
  • Intracerebroventricular injection
  • Nitric oxide
  • Sympathetic nervous system

 Download PDF

Email

Thank you for your interest in spreading the word on Disease Models & Mechanisms.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
(Your Name) has sent you a message from Disease Models & Mechanisms
(Your Name) thought you would like to see the Disease Models & Mechanisms web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
RESEARCH ARTICLE
Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
Disease Models & Mechanisms 2015 8: 1427-1439; doi: 10.1242/dmm.019695
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
RESEARCH ARTICLE
Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
Disease Models & Mechanisms 2015 8: 1427-1439; doi: 10.1242/dmm.019695

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts

Please log in to add an alert for this article.

Sign in to email alerts with your email address

Article navigation

  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • RESULTS
    • DISCUSSION
    • MATERIALS AND METHODS
    • Acknowledgements
    • Footnotes
    • References
  • Figures & tables
  • Supp info
  • Info & metrics
  • PDF + SI
  • PDF

Related articles

Cited by...

More in this TOC section

  • The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression
  • Altered cytoskeletal arrangement in induced pluripotent stem cells and motor neurons from patients with riboflavin transporter deficiency
  • Cardiovascular phenotype of the Dmdmdx rat – a suitable animal model for Duchenne muscular dystrophy
Show more RESEARCH ARTICLE

Similar articles

Other journals from The Company of Biologists

Development

Journal of Cell Science

Journal of Experimental Biology

Biology Open

Advertisement

DMM and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.


Monica Justice bids farewell to DMM

In her farewell Editorial, outgoing Editor-in-Chief Monica Justice reminds us of the past half-decade of growth and of DMM's commitment to support the disease modelling community, concluding, “The knowledge and experience I gained during my time as Senior Editor and EiC at DMM is invaluable: working within a not-for-profit community publishing environment is a joy.”


3D imaging of beta cell mass in diabetic mouse models

In their inducible mouse model of diabetes, Roostalu et al. demonstrate how quantitative light-sheet imaging can capture changes in individual islets to help pharmacological research in diabetes.

Visit our YouTube channel to watch more videos from DMM, our sister journals and the Company.


Modelling Joubert syndrome patient-derived mutations in C. elegans

In this issue’s Editor’s choice, Karen Lange and colleagues used C. elegans to model and characterise two patient-derived mutations that cause the ciliopathy Joubert syndrome.


Interview – Karen Lange

First author of our current Editor’s choice, Karen Lange takes us behind the scenes of the paper, and shares her thoughts on how the lack of both time and job security will impact her research.

Articles

  • Accepted manuscripts
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Subject collections
  • Interviews
  • Sign up for alerts

About us

  • About DMM
  • Editors and Board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact DMM
  • Advertising
  • Feedback

Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992