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  Open access

November, 2015; 8 (11)

EDITORIAL

  • Open Access
    Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease
    Chris Armit
    Disease Models & Mechanisms 2015 8: 1341-1343; doi: 10.1242/dmm.023606

    Summary: A recent report by White et al. highlights the utility of lacZ reporter gene expression profiling as a powerful means of elucidating the role of genes in health and disease.

A MODEL FOR LIFE

  • Open Access
    Exploring cell apoptosis and senescence to understand and treat cancer: an interview with Scott Lowe
    Disease Models & Mechanisms 2015 8: 1345-1348; doi: 10.1242/dmm.023531

REVIEW

  • Open Access
    Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models
    Philip M. Elks, Stephen A. Renshaw, Annemarie H. Meijer, Sarah R. Walmsley, Fredericus J. van Eeden
    Disease Models & Mechanisms 2015 8: 1349-1360; doi: 10.1242/dmm.021865

    Summary: Hypoxia signalling, mediated by HIF, is a crucial pathway in many disease processes. Here, we review current knowledge of HIF signalling and disease, focusing on recent findings from zebrafish models.

RESEARCH ARTICLES

  • Open Access
    A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
    Michael Buchert, Franziska Rohde, Moritz Eissmann, Niall Tebbutt, Ben Williams, Chin Wee Tan, Alexander Owen, Yumiko Hirokawa, Alexandra Gnann, Gertraud Orend, Gayle Orner, Rod H. Dashwood, Joan K. Heath, Matthias Ernst, Klaus-Peter Janssen
    Disease Models & Mechanisms 2015 8: 1361-1373; doi: 10.1242/dmm.019844

    Summary: The gpA33ΔN-Bcat mice provide a model that better mimics some aspects of sporadic colon cancer induction in humans in terms of tumor multiplicity and latency and site-specific (i.e. colon) tumor occurrence that coincides with upregulation of markers for human colorectal cancer progression.

  • Open Access
    A zebrafish larval model reveals early tissue-specific innate immune responses to Mucor circinelloides
    Kerstin Voelz, Remi L. Gratacap, Robert T. Wheeler
    Disease Models & Mechanisms 2015 8: 1375-1388; doi: 10.1242/dmm.019992

    Summary: We use zebrafish larval models to delineate the temporospatial patterns of innate immune responses to fungal infections with mucormycete spores.

  • Open Access
    Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons
    Katherina Beck, Nadine Ehmann, Till F. M. Andlauer, Dmitrij Ljaschenko, Katrin Strecker, Matthias Fischer, Robert J. Kittel, Thomas Raabe
    Disease Models & Mechanisms 2015 8: 1389-1400; doi: 10.1242/dmm.021246

    Summary: Mutations in the human kinase RSK2 are associated with severe mental retardation (Coffin-Lowry syndrome). Here, the function of Drosophila RSK in synaptic plasticity is described, which might help in understanding the complex pathophysiology.

  • Open Access
    T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice
    Ceri E. Oldreive, Anna Skowronska, Nicholas J. Davies, Helen Parry, Angelo Agathanggelou, Sergey Krysov, Graham Packham, Zbigniew Rudzki, Laura Cronin, Katerina Vrzalikova, Paul Murray, Elena Odintsova, Guy Pratt, A. Malcolm R. Taylor, Paul Moss, Tatjana Stankovic
    Disease Models & Mechanisms 2015 8: 1401-1412; doi: 10.1242/dmm.021147

    Summary: Manipulation of T cells can enhance current CLL xenograft models, expanding their utility for investigation of tumour biology and pre-clinical drug assessment.

  • Open Access
    Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology
    Srikanth Mairpady Shambat, Puran Chen, Anh Thu Nguyen Hoang, Helena Bergsten, Francois Vandenesch, Nikolai Siemens, Gerard Lina, Ian R. Monk, Timothy J. Foster, Gayathri Arakere, Mattias Svensson, Anna Norrby-Teglund
    Disease Models & Mechanisms 2015 8: 1413-1425; doi: 10.1242/dmm.021923

    Summary: Use of a human 3D lung tissue model system identifies the combined effects of α-toxin and Panton-Valentine leukocidin in tissue injury and clinical outcome in staphylococcal pneumonia.

  • Open Access
    Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
    María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
    Disease Models & Mechanisms 2015 8: 1427-1439; doi: 10.1242/dmm.019695

    Summary: Mice haploinsufficient for Alk1, a receptor for the TGF-β family, show hypertension, based on overactivation of the sympathetic nervous system and a reduction in the number of cholinergic neurons in the CNS.

  • Open Access
    Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood
    Laura Llobet, Janne M. Toivonen, Julio Montoya, Eduardo Ruiz-Pesini, Ester López-Gallardo
    Disease Models & Mechanisms 2015 8: 1441-1455; doi: 10.1242/dmm.021774

    Summary: Some medical drugs and environmental chemical pollutants acting on the oxidative phosphorylation system can alter adipocyte differentiation and adipogenesis and, thus, have important consequences for human health.

  • Open Access
    Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1)
    Flavio H. Beraldo, Anu Thomas, Benjamin Kolisnyk, Pedro H. Hirata, Xavier De Jaeger, Amanda C. Martyn, Jue Fan, Daniela F. Goncalves, Matthew F. Cowan, Talal Masood, Vilma R. Martins, Robert Gros, Vania F. Prado, Marco A. M. Prado
    Disease Models & Mechanisms 2015 8: 1457-1466; doi: 10.1242/dmm.022525

    Summary: Here, using a series of behavioral tests including touchscreen tasks we show that decreased levels of stress-inducible phosphoprotein 1 (STIP1) lead to attention deficits and hyperactivity in mice.

RESOURCE ARTICLES

  • Open Access
    A gene expression resource generated by genome-wide lacZ profiling in the mouse
    Elizabeth Tuck, Jeanne Estabel, Anika Oellrich, Anna Karin Maguire, Hibret A. Adissu, Luke Souter, Emma Siragher, Charlotte Lillistone, Angela L. Green, Hannah Wardle-Jones, Damian M. Carragher, Natasha A. Karp, Damian Smedley, Niels C. Adams, Sanger Institute Mouse Genetics Project, James N. Bussell, David J. Adams, Ramiro Ramírez-Solis, Karen P. Steel, Antonella Galli, Jacqueline K. White
    Disease Models & Mechanisms 2015 8: 1467-1478; doi: 10.1242/dmm.021238

    Editor's Choice: The report presents an open-access adult mouse expression resource, in which the expression profile of 424 genes has been assessed in up to 47 different organs, tissues and sub-structures using a lacZ reporter gene.

  • Open Access
    A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye
    Dawn A. Sim, Colin J. Chu, Senthil Selvam, Michael B. Powner, Sidath Liyanage, David A. Copland, Pearse A. Keane, Adnan Tufail, Catherine A. Egan, James W. B. Bainbridge, Richard W. Lee, Andrew D. Dick, Marcus Fruttiger
    Disease Models & Mechanisms 2015 8: 1479-1487; doi: 10.1242/dmm.019018

    Summary: We show here that peripheral leukocytes can be labelled with ICG in vivo and then directly imaged as they invade the retina after inflammatory stimuli.

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  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
  • Open Access

    Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

    Paco López-Cuevas, Luke Deane, Yushi Yang, Chrissy L Hammond, Erika Kague
    PDF
  • Open Access

    Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

    Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
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Monica Justice bids farewell to DMM

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Modelling Joubert syndrome patient-derived mutations in C. elegans

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Interview – Karen Lange

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