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  Open access

SUBJECT COLLECTION: MODEL SYSTEMS IN DRUG DISCOVERY
October 1, 2015; 8 (10)

EDITORIALS

  • Open Access
    From bench to patient: model systems in drug discovery
    Matthew D. Breyer, A. Thomas Look, Alessandra Cifra
    Disease Models & Mechanisms 2015 8: 1171-1174; doi: 10.1242/dmm.023036

    Drug Discovery Collection: This Editorial introduces the new DMM Special Collection entitled ‘From bench to patient: model systems in drug discovery’, providing a summary of its contents and highlighting the impact of multiple model systems in moving new discoveries from bench to patient.

  • Open Access
    Improving translational studies: lessons from rare neuromuscular diseases
    Dominic Wells
    Disease Models & Mechanisms 2015 8: 1175-1177; doi: 10.1242/dmm.022616

    Drug Discovery Collection: This Editorial reviews problems and some solutions to the translational use of animal models in the rare neuromuscular diseases context. This can serve as a model for other disease fields.

A MODEL FOR LIFE

  • Open Access
    Walking between academia and industry to find successful solutions to biomedical challenges: an interview with Geoffrey Smith
    Disease Models & Mechanisms 2015 8: 1179-1183; doi: 10.1242/dmm.022681

REVIEW

  • Open Access
    GEMMs as preclinical models for testing pancreatic cancer therapies
    Aarthi Gopinathan, Jennifer P. Morton, Duncan I. Jodrell, Owen J. Sansom
    Disease Models & Mechanisms 2015 8: 1185-1200; doi: 10.1242/dmm.021055

    Drug Discovery Collection: This Review discusses GEMMs of human pancreatic cancer, particularly focusing on the KPC model, its use in preclinical research, advantages and disadvantages, and its potential for predicting clinical outcomes.

RESEARCH ARTICLES

  • Open Access
    A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics
    Ozhan Ocal, Victor Pashkov, Rahul K. Kollipara, Yalda Zolghadri, Victoria H. Cruz, Michael A. Hale, Blake R. Heath, Alex B. Artyukhin, Alana L. Christie, Pantelis Tsoulfas, James B. Lorens, Galvin H. Swift, Rolf A. Brekken, Thomas M. Wilkie
    Disease Models & Mechanisms 2015 8: 1201-1211; doi: 10.1242/dmm.020933

    Editor's choice - Drug Discovery Collection: The study describes a rapid in vivo screen for novel strategies to treat pancreatic ductal adenocarcinoma (PDA).

  • Open Access
    Treatment with a novel oleic-acid–dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats
    Juan M. Decara, Francisco Javier Pavón, Juan Suárez, Miguel Romero-Cuevas, Elena Baixeras, Mariam Vázquez, Patricia Rivera, Ana L. Gavito, Bruno Almeida, Jesús Joglar, Rafael de la Torre, Fernando Rodríguez de Fonseca, Antonia Serrano
    Disease Models & Mechanisms 2015 8: 1213-1225; doi: 10.1242/dmm.019919

    Drug Discovery Collection: OLHHA is a safe drug with hepatoprotective and anti-steatotic effects on non-alcoholic fatty liver disease in obese rats.

  • Open Access
    Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo
    Fariba Poosti, Bao Tung Pham, Dorenda Oosterhuis, Klaas Poelstra, Harry van Goor, Peter Olinga, Jan-Luuk Hillebrands
    Disease Models & Mechanisms 2015 8: 1227-1236; doi: 10.1242/dmm.020172

    Drug Discovery Collection: TGFβ induces renal fibrosis in ex vivo cultured precision-cut kidney slices, which can be attenuated by IFNγ.

  • Open Access
    A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models
    Rosamaria Lappano, Camillo Rosano, Assunta Pisano, Maria Francesca Santolla, Ernestina Marianna De Francesco, Paola De Marco, Vincenza Dolce, Marco Ponassi, Lamberto Felli, Grazia Cafeo, Franz Heinrich Kohnke, Sergio Abonante, Marcello Maggiolini
    Disease Models & Mechanisms 2015 8: 1237-1246; doi: 10.1242/dmm.021071

    Drug Discovery Collection: This paper highlights mechanisms through which a calixpyrrole derivative acts as a newly identified selective antagonist of GPER in different model systems.

  • Open Access
    Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice
    Chao-Cheng Huang, Shuo-Yu Wang, Li-Ling Lin, Pei-Wen Wang, Ting-Ya Chen, Wen-Ming Hsu, Tsu-Kung Lin, Chia-Wei Liou, Jiin-Haur Chuang
    Disease Models & Mechanisms 2015 8: 1247-1254; doi: 10.1242/dmm.021667

    Drug Discovery Collection: Neuroblastomas are sensitive to treatment with the glycolytic inhibitor 2-deoxyglucose, which can simultaneously target cancer and endothelial cells to suppress tumor growth.

RESOURCE ARTICLE

  • Open Access
    From drug response profiling to target addiction scoring in cancer cell models
    Bhagwan Yadav, Peddinti Gopalacharyulu, Tea Pemovska, Suleiman A. Khan, Agnieszka Szwajda, Jing Tang, Krister Wennerberg, Tero Aittokallio
    Disease Models & Mechanisms 2015 8: 1255-1264; doi: 10.1242/dmm.021105

    Drug Discovery Collection: The authors take a pan-cancer approach that provides functional insights into molecular vulnerabilities across various cancer subtypes and patient-specific target addiction patterns that could lead to actionable treatment strategies.

RESEARCH ARTICLES

  • Open Access
    Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig
    Vanessa J. Hall, Maiken M. Lindblad, Jannik E. Jakobsen, Anders Gunnarsson, Mette Schmidt, Mikkel A. Rasmussen, Daniela Volke, Thole Zuchner, Poul Hyttel
    Disease Models & Mechanisms 2015 8: 1265-1278; doi: 10.1242/dmm.019489

    Summary: Insight into astrocyte and radial glia pathology in an in vitro culture system derived from the APPsw pig.

  • Open Access
    Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy
    Eva Külshammer, Juliane Mundorf, Merve Kilinc, Peter Frommolt, Prerana Wagle, Mirka Uhlirova
    Disease Models & Mechanisms 2015 8: 1279-1293; doi: 10.1242/dmm.020719

    Summary: This study provides genetic evidence that malignancy driven by oncogenic Ras and loss of polarity requires transcription factors of three distinct protein families, acting in synergy downstream of JNK signaling.

  • Open Access
    OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells
    Ravinder Kaur, Christopher Aiken, Ludivine Coudière Morrison, Radhika Rao, Marc R. Del Bigio, Shravanti Rampalli, Tamra Werbowetski-Ogilvie
    Disease Models & Mechanisms 2015 8: 1295-1309; doi: 10.1242/dmm.020594

    Summary: Human embryonic stem cell neural derivatives can be used to model the molecular and cellular properties of medulloblastoma.

  • Open Access
    Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
    Huei-Fen Jheng, Pei-Jane Tsai, Yi-Lun Chuang, Yi-Ting Shen, Ting-An Tai, Wen-Chung Chen, Chuan-Kai Chou, Li-Chun Ho, Ming-Jer Tang, Kuei-Tai A. Lai, Junne-Ming Sung, Yau-Sheng Tsai
    Disease Models & Mechanisms 2015 8: 1311-1321; doi: 10.1242/dmm.019398

    Summary: Activation of the HSP70-TLR4 axis by albumin in the tubular cell induces tubular inflammation and injury.

  • Open Access
    Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats
    Lara Sedó-Cabezón, Paulina Jedynak, Pere Boadas-Vaello, Jordi Llorens
    Disease Models & Mechanisms 2015 8: 1323-1337; doi: 10.1242/dmm.021436

    Summary: New forms of damage and repair have been identified in the vestibular sensory epithelium using a rat model of chronic ototoxicity and recovery that causes reversible vestibular dysfunction.

CORRECTION

  • You have accessSubscription required
    A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations
    Greger Abrahamsen, Yongjun Fan, Nicholas Matigian, Gautam Wali, Bernadette Bellette, Ratneswary Sutharsan, Jyothy Raju, Stephen A. Wood, David Veivers, Carolyn M. Sue, Alan Mackay-Sim
    Disease Models & Mechanisms 2015 8: 1339 doi: 10.1242/dmm.023002
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  • Open Access

    Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes

    Phillipe D. O'Brien, Kai Guo, Stephanie A. Eid, Amy E. Rumora, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson, Junguk Hur, Eva L. Feldman
    PDF
  • Open Access

    A comparison of the bone and growth phenotype of mdx, mdx:cmah−/− and mdx:utrn+/− murine models with the C57BL10 wildtype mouse

    C. L. Wood, K. J. Suchaki, R. van 't Hof, W. P. Cawthorn, S. Dillon, V. Straub, S. C. Wong, S. F. Ahmed, C. Farquharson
    PDF
  • Open Access

    Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

    Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger
    PDF
  • Open Access

    A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries

    Omkara Lakshmi Veeranki, Zhimin Tong, Alicia Mejia, Anuj Verma, Riham Katkhuda, Roland Bassett, Tae-Beom Kim, Jing Wang, Wenhua Lang, Barbara Mino, Luisa Solis, Charles Kingsley, William Norton, Ramesh Tailor, Ji Yuan Wu, Sunil Krishnan, Steven H. Lin, Mariela Blum, Wayne Hofstetter, Jaffer Ajani, Scott Kopetz, Dipen Maru
    PDF
  • Open Access

    A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

    Alberto Rissone, Erin Jimenez, Kevin Bishop, Blake Carrington, Claire Slevin, Stephen M. Wincovitch, Raman Sood, Fabio Candotti, Shawn M. Burgess
    PDF
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