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  Open access

December, 2014; 7 (12)

IN THIS ISSUE

  • Open Access
    Modelling drug-induced neocortical toxicity in vitro
    Disease Models & Mechanisms 2014 7: e1201
  • Open Access
    Loss of WT huntingtin impairs ER-to-Golgi transport
    Disease Models & Mechanisms 2014 7: e1202
  • Open Access
    A role for bone mineralisation factors in obesity and diabetes
    Disease Models & Mechanisms 2014 7: e1203

A MODEL FOR LIFE

  • Open Access
    ‘Back and forth’ from models to patients to understand kidney disease: an interview with Katalin Susztak
    Disease Models & Mechanisms 2014 7: 1317-1319; doi: 10.1242/dmm.018911

REVIEW

  • Open Access
    The challenge of translating ischemic conditioning from animal models to humans: the role of comorbidities
    Kieran McCafferty, Suzanne Forbes, Christoph Thiemermann, Muhammad M. Yaqoob
    Disease Models & Mechanisms 2014 7: 1321-1333; doi: 10.1242/dmm.016741

RESEARCH ARTICLES

  • Open Access
    Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane
    Hemma Brandstaetter, Antonina J. Kruppa, Folma Buss
    Disease Models & Mechanisms 2014 7: 1335-1340; doi: 10.1242/dmm.017368
  • Open Access
    Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes
    Carmen Huesa, Dongxing Zhu, James D. Glover, Mathieu Ferron, Gerard Karsenty, Elspeth M. Milne, José Luis Millan, S. Faisal Ahmed, Colin Farquharson, Nicholas M. Morton, Vicky E. MacRae
    Disease Models & Mechanisms 2014 7: 1341-1350; doi: 10.1242/dmm.017905
  • Open Access
    Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo
    Mark W. Dodson, Lok K. Leung, Mohiddin Lone, Michael A. Lizzio, Ming Guo
    Disease Models & Mechanisms 2014 7: 1351-1363; doi: 10.1242/dmm.017020
  • Open Access
    Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model
    Patricia Jumbo-Lucioni, William Parkinson, Kendal Broadie
    Disease Models & Mechanisms 2014 7: 1365-1378; doi: 10.1242/dmm.017137
  • Open Access
    Transgenic mouse model of cutaneous adnexal tumors
    Yusuke Kito, Chiemi Saigo, Kurabayashi Atsushi, Furihata Mutsuo, Takeuchi Tamotsu
    Disease Models & Mechanisms 2014 7: 1379-1383; doi: 10.1242/dmm.017574
  • Open Access
    Triptolide treatment reduces Alzheimer’s disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD
    Qi Wang, Bing Xiao, Shuqin Cui, Hailong Song, Yanjing Qian, Lin Dong, Haiting An, Yanqiu Cui, Wenjing Zhang, Yi He, Jianliang Zhang, Jian Yang, Feilong Zhang, Guanzheng Hu, Xiaoli Gong, Zhen Yan, Yan Zheng, Xiaomin Wang
    Disease Models & Mechanisms 2014 7: 1385-1395; doi: 10.1242/dmm.018218

RESOURCE ARTICLES

  • Open Access
    An in vitro model of human neocortical development using pluripotent stem cells: cocaine-induced cytoarchitectural alterations
    Abigail A. Kindberg, Raphael M. Bendriem, Charles E. Spivak, Jia Chen, Annelie Handreck, Carl R. Lupica, Jinny Liu, William J. Freed, Chun-Ting Lee
    Disease Models & Mechanisms 2014 7: 1397-1405; doi: 10.1242/dmm.017251
  • Open Access
    Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy
    Joachim Berger, Hakan Tarakci, Silke Berger, Mei Li, Thomas E. Hall, Anders Arner, Peter D. Currie
    Disease Models & Mechanisms 2014 7: 1407-1415; doi: 10.1242/dmm.017376
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Disease Models & Mechanisms: 7 (12)
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  • Open Access

    Neural crest-specific deletion of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction, and disordered breathing modelling Obstructive Sleep Apnea

    Pranidhi Baddam, Vivian Biancardi, Daniela M. Roth, Farah Eaton, Claudine Thereza-Bussolaro, Rupasri Mandal, David S. Wishart, Amy Barr, Joanna MacLean, Carlos Flores-Mir, Silvia Pagliardini, Daniel Graf
    PDF
  • Open Access

    Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

    F. W. Riemslagh, E. C. van der Toorn, R. F. M. Verhagen, A. Maas, L. W. J. Bosman, R. K. Hukema, R. Willemsen
    PDF
  • Open Access

    A muscle growth promoting treatment based on the attenuation of activin/myostatin signalling in young mice results in long-term testicular abnormalities

    Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
    PDF
  • Open Access

    TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

    Rachel Atkinson, Jacqueline Leung, James Bender, Matthew Kirkcaldie, James Vickers, Anna King
    PDF
  • Open Access

    Interpreting the pathogenicity of Joubert Syndrome missense variants in Caenorhabditis elegans

    Karen I. Lange, Sofia Tsiropoulou, Katarzyna Kucharska, Oliver E. Blacque
    PDF
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Professor Elizabeth Patton appointed as DMM’s next Editor-in-Chief

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Interview – Kim Landry-Truchon and Nicolas Houde

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