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Editor’s Choice - Development of mouse models of angiosarcoma driven by p53
Valerie Brunton and colleagues report that deletion of p53 in endothelial cells leads to reliable angiosarcoma generation, which, along with establishment of a transplantation model, provides a novel approach for testing potential new therapeutics.
Organoids are self-organizing tissues derived from stem cells that provide a unique system to examine organ development, homeostasis and disease. This At a Glance by Madeline Lancaster and Meritxell Huch summarises the current organoid models of several human diseases, and discusses future prospects for these technologies.
An injection-based chordoma model in zebrafish shows that the hypothesized chordoma oncogene brachyury is insufficient, whereas EGFR and VEGFR2 are sufficient, to trigger notochord hyperplasia, find Alexa Burger and colleagues.
First Person interviews
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with Marie Rodinova and Christiaan Veerman.
DMM partners with Publons for peer reviewer recognition
Disease Models & Mechanisms is pleased to announce a new partnership with Publons, part of the Web of Science Group (a Clarivate Analytics company). Publons gives reviewers formal recognition of their peer review contributions using the Reviewer Recognition Service.
preLights - Injury stimulates stem cells to resist radiation-induced apoptosis
Maya Emmons-Bell highlights a preprint showing that wounding a planarian shortly after radiation protects stem cells from death, which is important for regenerative growth. This work provides important insight into the complex reactions that occur upon tissue injury.
Catch up with recent preLights selected for the translational biology community.