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  You have access

  Open access

November 1, 2013; 6 (6)

In This Issue

  • Open Access
    Polyunsaturated fatty acids: an alternative to statins for treating heart disease?
    Disease Models & Mechanisms 2013 6: 1299
  • Open Access
    A reliable mouse model for studying intestinal epithelial damage
    Disease Models & Mechanisms 2013 6: 1299
  • Open Access
    A new druggable target for clinical management of COPD
    Disease Models & Mechanisms 2013 6: 1299
  • Open Access
    Insights into kidney disease using a bicongenic rat model
    Disease Models & Mechanisms 2013 6: 1299
  • Open Access
    Cre-recombinase-associated toxicity highlights limitations of genome editing
    Disease Models & Mechanisms 2013 6: 1299-1300;

Community News

  • Open Access
    Building bridges with zebrafish: highlights of the ‘Zebrafish Models in Translational Medicine’ meeting
    Disease Models & Mechanisms 2013 6: 1301-1302; doi: 10.1242/dmm.014571

A Model For Life

  • Open Access
    Using zebrafish to shed light on melanoma: an interview with Liz Patton
    Disease Models & Mechanisms 2013 6: 1303-1306; doi: 10.1242/dmm.014340

At A Glance

  • Open Access
    The pathophysiology of traumatic brain injury at a glance
    Mayumi Prins, Tiffany Greco, Daya Alexander, Christopher C. Giza
    Disease Models & Mechanisms 2013 6: 1307-1315; doi: 10.1242/dmm.011585

Special Article

  • Open Access
    A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson’s Research
    Marco A. S. Baptista, Kuldip D. Dave, Niketa P. Sheth, Shehan N. De Silva, Kirsten M. Carlson, Yasmin N. Aziz, Brian K. Fiske, Todd B. Sherer, Mark A. Frasier
    Disease Models & Mechanisms 2013 6: 1316-1324; doi: 10.1242/dmm.011940

Reviews

  • Open Access
    Towards clinical management of traumatic brain injury: a review of models and mechanisms from a biomechanical perspective
    Dhananjay R. Namjoshi, Craig Good, Wai Hang Cheng, William Panenka, Darrin Richards, Peter A. Cripton, Cheryl L. Wellington
    Disease Models & Mechanisms 2013 6: 1325-1338; doi: 10.1242/dmm.011320
  • Open Access
    Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models
    Fabio Demontis, Rosanna Piccirillo, Alfred L. Goldberg, Norbert Perrimon
    Disease Models & Mechanisms 2013 6: 1339-1352; doi: 10.1242/dmm.012559
  • Open Access
    Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
    Franziska Baenke, Barrie Peck, Heike Miess, Almut Schulze
    Disease Models & Mechanisms 2013 6: 1353-1363; doi: 10.1242/dmm.011338

Research Articles

  • Open Access
    Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice
    Santhosh Karanth, Vy My Tran, Balagurunathan Kuberan, Amnon Schlegel
    Disease Models & Mechanisms 2013 6: 1365-1377; doi: 10.1242/dmm.013425
  • Open Access
    Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD
    Juliana Heidler, Athanasios Fysikopoulos, Frank Wempe, Michael Seimetz, Thorsten Bangsow, Ana Tomasovic, Florian Veit, Susan Scheibe, Alexandra Pichl, Friederike Weisel, K. C. Kent Lloyd, Peter Jaksch, Walter Klepetko, Norbert Weissmann, Harald von Melchner
    Disease Models & Mechanisms 2013 6: 1378-1387; doi: 10.1242/dmm.013482
  • Open Access
    A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
    Jonathan M. Williams, Carrie A. Duckworth, Alastair J. M. Watson, Mark R. Frey, Jennifer C. Miguel, Michael D. Burkitt, Robert Sutton, Kevin R. Hughes, Lindsay J. Hall, Jorge H. Caamaño, Barry J. Campbell, D. Mark Pritchard
    Disease Models & Mechanisms 2013 6: 1388-1399; doi: 10.1242/dmm.013284
  • Open Access
    Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila
    Samuel H. Friedman, Neil Dani, Emma Rushton, Kendal Broadie
    Disease Models & Mechanisms 2013 6: 1400-1413; doi: 10.1242/dmm.012229
  • Open Access
    A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth
    Benedetta Gualeni, M. Helen Rajpar, Aaron Kellogg, Peter A. Bell, Peter Arvan, Raymond P. Boot-Handford, Michael D. Briggs
    Disease Models & Mechanisms 2013 6: 1414-1425; doi: 10.1242/dmm.013342
  • Open Access
    Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice
    Fenny Wiradjaja, Denny L. Cottle, Lynelle Jones, Ian Smyth
    Disease Models & Mechanisms 2013 6: 1426-1433; doi: 10.1242/dmm.013748
  • Open Access
    Diabetes induces stable intrinsic changes to myeloid cells that contribute to chronic inflammation during wound healing in mice
    Pauline Bannon, Sally Wood, Terry Restivo, Laura Campbell, Matthew J. Hardman, Kimberly A. Mace
    Disease Models & Mechanisms 2013 6: 1434-1447; doi: 10.1242/dmm.012237
  • Open Access
    Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice
    Philip E. Lapinski, Melissa F. Meyer, Gen-Sheng Feng, Nobuhiro Kamiya, Philip D. King
    Disease Models & Mechanisms 2013 6: 1448-1458; doi: 10.1242/dmm.012849
  • Open Access
    Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death
    Kevin Bersell, Sangita Choudhury, Mariya Mollova, Brian D. Polizzotti, Balakrishnan Ganapathy, Stuart Walsh, Brian Wadugu, Shima Arab, Bernhard Kühn
    Disease Models & Mechanisms 2013 6: 1459-1469; doi: 10.1242/dmm.010447

Research Report

  • Open Access
    Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver
    Jonas Lexow, Tommaso Poggioli, Padmini Sarathchandra, Maria Paola Santini, Nadia Rosenthal
    Disease Models & Mechanisms 2013 6: 1470-1476; doi: 10.1242/dmm.010470

Resource Articles

  • Open Access
    Experimental crescentic glomerulonephritis: a new bicongenic rat model
    Zelpha D’Souza, Stephen P. McAdoo, Jennifer Smith, Charles D. Pusey, H. Terence Cook, Jacques Behmoaras, Timothy J. Aitman
    Disease Models & Mechanisms 2013 6: 1477-1486; doi: 10.1242/dmm.012328
  • Open Access
    Establishment of a novel extracorporeal bowel model to study luminal approaches to treat inflammatory bowel disease
    Anne Breitrück, Gisela Sparmann, Steffen Mitzner, Claus Kerkhoff
    Disease Models & Mechanisms 2013 6: 1487-1493; doi: 10.1242/dmm.011734
  • Open Access
    A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)
    Brandi L. Carofino, Bernard Ayanga, Monica J. Justice
    Disease Models & Mechanisms 2013 6: 1494-1506; doi: 10.1242/dmm.012575
  • Open Access
    An insert-based enzymatic cell culture system to rapidly and reversibly induce hypoxia: investigations of hypoxia-induced cell damage, protein expression and phosphorylation in neuronal IMR-32 cells
    Ying Huang, Karina Zitta, Berthold Bein, Markus Steinfath, Martin Albrecht
    Disease Models & Mechanisms 2013 6: 1507-1514; doi: 10.1242/dmm.013078
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Disease Models & Mechanisms: 6 (6)
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  • Open Access

    A comparison of the bone and growth phenotype of mdx, mdx:cmah−/− and mdx:utrn+/− murine models with the C57BL10 wildtype mouse

    C. L. Wood, K. J. Suchaki, R. van 't Hof, W. P. Cawthorn, S. Dillon, V. Straub, S. C. Wong, S. F. Ahmed, C. Farquharson
    PDF
  • Open Access

    Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

    Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger
    PDF
  • Open Access

    A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries

    Omkara Lakshmi Veeranki, Zhimin Tong, Alicia Mejia, Anuj Verma, Riham Katkhuda, Roland Bassett, Tae-Beom Kim, Jing Wang, Wenhua Lang, Barbara Mino, Luisa Solis, Charles Kingsley, William Norton, Ramesh Tailor, Ji Yuan Wu, Sunil Krishnan, Steven H. Lin, Mariela Blum, Wayne Hofstetter, Jaffer Ajani, Scott Kopetz, Dipen Maru
    PDF
  • Open Access

    A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

    Alberto Rissone, Erin Jimenez, Kevin Bishop, Blake Carrington, Claire Slevin, Stephen M. Wincovitch, Raman Sood, Fabio Candotti, Shawn M. Burgess
    PDF
  • Open Access

    Notch4 activation aggravates NF-kappa B mediated inflammation in HIV-1 associated Nephropathy

    Rajni Vaid Puri, Sireesha Yerrathota, Trisha Home, Jessica Y. Idowu, Praveen V. Chakravarthi, Christopher J. Ward, Pravin Singhal, Gregory B. Vanden Heuvel, Timothy A. Fields, Madhulika Sharma
    PDF
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Editor’s choice – Perturbed development of cranial neural crest cells in association with reduced sonic hedgehog signaling underlies the pathogenesis of retinoic-acid-induced cleft palate

Schematic showing that excessive RA signaling reduces Shh signaling, which results in elevated cell death of CNCCs and cleft palate.

Takashi Yamashiro and colleagues identify the critical role of the retinoic acid-Sonic hedgehog signalling pathway in cranial neural crest and palate development.


Featured article – Deep learning enables automated volumetric assessments of cardiac function in zebrafish

A graphical 3D reconstruction of ventricular EDV and ESV as measured by CFIN.

A new Resource article by Nguyen et al. describes CFIN, a novel deep learning image analysis platform to assess cardiac function in embryonic zebrafish. 


Review – CRISPR/Cas9-mediated genome editing in nonhuman primates

Two pictures of non-human primates commonly used in genome editing research.

Yuyu Niu and colleagues summarise the history of genome editing in non-human primates and discusses the challenges and prospects of the technology.


First person interviews

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Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with Alexander Akerberg and Jocelyn Wessels. 


Travelling Fellowship – New imaging approach unveils a bigger picture

Highlights from Travelling Fellowships trips.

Find out how Pamela Imperadore’s Travelling Fellowship grant from The Company of Biologists took her to Germany, where she used new imaging techniques to investigate the cellular machinery underlying octopus arm regeneration. Don’t miss the next application deadline for 2020 travel, coming up on 29 November. Where will you go?


preLights – HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa

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