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  Open access

November, 2013; 6 (6)

In This Issue

  • Open Access
    Polyunsaturated fatty acids: an alternative to statins for treating heart disease?
    Disease Models & Mechanisms 2013 6: 1299
  • Open Access
    A reliable mouse model for studying intestinal epithelial damage
    Disease Models & Mechanisms 2013 6: 1299
  • Open Access
    A new druggable target for clinical management of COPD
    Disease Models & Mechanisms 2013 6: 1299
  • Open Access
    Insights into kidney disease using a bicongenic rat model
    Disease Models & Mechanisms 2013 6: 1299
  • Open Access
    Cre-recombinase-associated toxicity highlights limitations of genome editing
    Disease Models & Mechanisms 2013 6: 1299-1300;

Community News

  • Open Access
    Building bridges with zebrafish: highlights of the ‘Zebrafish Models in Translational Medicine’ meeting
    Disease Models & Mechanisms 2013 6: 1301-1302; doi: 10.1242/dmm.014571

A Model For Life

  • Open Access
    Using zebrafish to shed light on melanoma: an interview with Liz Patton
    Disease Models & Mechanisms 2013 6: 1303-1306; doi: 10.1242/dmm.014340

At A Glance

  • Open Access
    The pathophysiology of traumatic brain injury at a glance
    Mayumi Prins, Tiffany Greco, Daya Alexander, Christopher C. Giza
    Disease Models & Mechanisms 2013 6: 1307-1315; doi: 10.1242/dmm.011585

Special Article

  • Open Access
    A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson’s Research
    Marco A. S. Baptista, Kuldip D. Dave, Niketa P. Sheth, Shehan N. De Silva, Kirsten M. Carlson, Yasmin N. Aziz, Brian K. Fiske, Todd B. Sherer, Mark A. Frasier
    Disease Models & Mechanisms 2013 6: 1316-1324; doi: 10.1242/dmm.011940

Reviews

  • Open Access
    Towards clinical management of traumatic brain injury: a review of models and mechanisms from a biomechanical perspective
    Dhananjay R. Namjoshi, Craig Good, Wai Hang Cheng, William Panenka, Darrin Richards, Peter A. Cripton, Cheryl L. Wellington
    Disease Models & Mechanisms 2013 6: 1325-1338; doi: 10.1242/dmm.011320
  • Open Access
    Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models
    Fabio Demontis, Rosanna Piccirillo, Alfred L. Goldberg, Norbert Perrimon
    Disease Models & Mechanisms 2013 6: 1339-1352; doi: 10.1242/dmm.012559
  • Open Access
    Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
    Franziska Baenke, Barrie Peck, Heike Miess, Almut Schulze
    Disease Models & Mechanisms 2013 6: 1353-1363; doi: 10.1242/dmm.011338

Research Articles

  • Open Access
    Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice
    Santhosh Karanth, Vy My Tran, Balagurunathan Kuberan, Amnon Schlegel
    Disease Models & Mechanisms 2013 6: 1365-1377; doi: 10.1242/dmm.013425
  • Open Access
    Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD
    Juliana Heidler, Athanasios Fysikopoulos, Frank Wempe, Michael Seimetz, Thorsten Bangsow, Ana Tomasovic, Florian Veit, Susan Scheibe, Alexandra Pichl, Friederike Weisel, K. C. Kent Lloyd, Peter Jaksch, Walter Klepetko, Norbert Weissmann, Harald von Melchner
    Disease Models & Mechanisms 2013 6: 1378-1387; doi: 10.1242/dmm.013482
  • Open Access
    A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
    Jonathan M. Williams, Carrie A. Duckworth, Alastair J. M. Watson, Mark R. Frey, Jennifer C. Miguel, Michael D. Burkitt, Robert Sutton, Kevin R. Hughes, Lindsay J. Hall, Jorge H. Caamaño, Barry J. Campbell, D. Mark Pritchard
    Disease Models & Mechanisms 2013 6: 1388-1399; doi: 10.1242/dmm.013284
  • Open Access
    Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila
    Samuel H. Friedman, Neil Dani, Emma Rushton, Kendal Broadie
    Disease Models & Mechanisms 2013 6: 1400-1413; doi: 10.1242/dmm.012229
  • Open Access
    A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth
    Benedetta Gualeni, M. Helen Rajpar, Aaron Kellogg, Peter A. Bell, Peter Arvan, Raymond P. Boot-Handford, Michael D. Briggs
    Disease Models & Mechanisms 2013 6: 1414-1425; doi: 10.1242/dmm.013342
  • Open Access
    Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice
    Fenny Wiradjaja, Denny L. Cottle, Lynelle Jones, Ian Smyth
    Disease Models & Mechanisms 2013 6: 1426-1433; doi: 10.1242/dmm.013748
  • Open Access
    Diabetes induces stable intrinsic changes to myeloid cells that contribute to chronic inflammation during wound healing in mice
    Pauline Bannon, Sally Wood, Terry Restivo, Laura Campbell, Matthew J. Hardman, Kimberly A. Mace
    Disease Models & Mechanisms 2013 6: 1434-1447; doi: 10.1242/dmm.012237
  • Open Access
    Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice
    Philip E. Lapinski, Melissa F. Meyer, Gen-Sheng Feng, Nobuhiro Kamiya, Philip D. King
    Disease Models & Mechanisms 2013 6: 1448-1458; doi: 10.1242/dmm.012849
  • Open Access
    Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death
    Kevin Bersell, Sangita Choudhury, Mariya Mollova, Brian D. Polizzotti, Balakrishnan Ganapathy, Stuart Walsh, Brian Wadugu, Shima Arab, Bernhard Kühn
    Disease Models & Mechanisms 2013 6: 1459-1469; doi: 10.1242/dmm.010447

Research Report

  • Open Access
    Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver
    Jonas Lexow, Tommaso Poggioli, Padmini Sarathchandra, Maria Paola Santini, Nadia Rosenthal
    Disease Models & Mechanisms 2013 6: 1470-1476; doi: 10.1242/dmm.010470

Resource Articles

  • Open Access
    Experimental crescentic glomerulonephritis: a new bicongenic rat model
    Zelpha D’Souza, Stephen P. McAdoo, Jennifer Smith, Charles D. Pusey, H. Terence Cook, Jacques Behmoaras, Timothy J. Aitman
    Disease Models & Mechanisms 2013 6: 1477-1486; doi: 10.1242/dmm.012328
  • Open Access
    Establishment of a novel extracorporeal bowel model to study luminal approaches to treat inflammatory bowel disease
    Anne Breitrück, Gisela Sparmann, Steffen Mitzner, Claus Kerkhoff
    Disease Models & Mechanisms 2013 6: 1487-1493; doi: 10.1242/dmm.011734
  • Open Access
    A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)
    Brandi L. Carofino, Bernard Ayanga, Monica J. Justice
    Disease Models & Mechanisms 2013 6: 1494-1506; doi: 10.1242/dmm.012575
  • Open Access
    An insert-based enzymatic cell culture system to rapidly and reversibly induce hypoxia: investigations of hypoxia-induced cell damage, protein expression and phosphorylation in neuronal IMR-32 cells
    Ying Huang, Karina Zitta, Berthold Bein, Markus Steinfath, Martin Albrecht
    Disease Models & Mechanisms 2013 6: 1507-1514; doi: 10.1242/dmm.013078
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Disease Models & Mechanisms: 6 (6)
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  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
  • Open Access

    Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

    Paco López-Cuevas, Luke Deane, Yushi Yang, Chrissy L Hammond, Erika Kague
    PDF
  • Open Access

    Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

    Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
    PDF
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DMM and COVID-19

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Monica Justice bids farewell to DMM

In her farewell Editorial, outgoing Editor-in-Chief Monica Justice reminds us of the past half-decade of growth and of DMM's commitment to support the disease modelling community, concluding, “The knowledge and experience I gained during my time as Senior Editor and EiC at DMM is invaluable: working within a not-for-profit community publishing environment is a joy.”


3D imaging of beta cell mass in diabetic mouse models

In their inducible mouse model of diabetes, Roostalu et al. demonstrate how quantitative light-sheet imaging can capture changes in individual islets to help pharmacological research in diabetes.

Visit our YouTube channel to watch more videos from DMM, our sister journals and the Company.


Modelling Joubert syndrome patient-derived mutations in C. elegans

In this issue’s Editor’s choice, Karen Lange and colleagues used C. elegans to model and characterise two patient-derived mutations that cause the ciliopathy Joubert syndrome.


Interview – Karen Lange

First author of our current Editor’s choice, Karen Lange takes us behind the scenes of the paper, and shares her thoughts on how the lack of both time and job security will impact her research.

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