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  You have access

  Open access

May, 2013; 6 (3)

In This Issue

  • Open Access
    Bioelectric signals: a diagnostic marker for cancer
    Disease Models & Mechanisms 2013 6: 555
  • Open Access
    Respiratory failure in myotonic dystrophy 1
    Disease Models & Mechanisms 2013 6: 555
  • Open Access
    New mouse model for Parkinson’s disease
    Disease Models & Mechanisms 2013 6: 555
  • Open Access
    Innate immunity: clues from zebrafish
    Disease Models & Mechanisms 2013 6: 555
  • Open Access
    EPO pre-treatment for haemorrhagic shock
    Disease Models & Mechanisms 2013 6: 555
  • Open Access
    Role of CagA in H. pylori gastric cancer
    Disease Models & Mechanisms 2013 6: 555-556;
  • Open Access
    Patient-derived iPSCs: a new model for Friedreich’s ataxia
    Disease Models & Mechanisms 2013 6: 556
  • Open Access
    Biomaterial promotes muscle cell regeneration in vivo
    Disease Models & Mechanisms 2013 6: 556
  • Open Access
    An inducible knockout mouse model for PTEN cancers
    Disease Models & Mechanisms 2013 6: 556

Editorials

  • Open Access
    Provoking progress: a new chapter
    Vivian Siegel Founding Editor-in-Chief
    Disease Models & Mechanisms 2013 6: 557-558; doi: 10.1242/dmm.012419
  • Open Access
    Bridging the gap between basic and applied biology: towards preclinical translation
    Ross L. Cagan, Monica J. Justice, George F. Tidmarsh
    Disease Models & Mechanisms 2013 6: 559-561; doi: 10.1242/dmm.012450
  • Open Access
    Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice
    Timothy Mohun, David J. Adams, Richard Baldock, Shoumo Bhattacharya, Andrew J. Copp, Myriam Hemberger, Corinne Houart, Matt E. Hurles, Elizabeth Robertson, James C. Smith, Tom Weaver, Wolfgang Weninger
    Disease Models & Mechanisms 2013 6: 562-566; doi: 10.1242/dmm.011957

A Model For Life

  • Open Access
    Bench to bedside with fruit flies: an interview with Ross Cagan
    Disease Models & Mechanisms 2013 6: 567-569; doi: 10.1242/dmm.012443

Special Article

  • Open Access
    Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening
    David Adams, Richard Baldock, Shoumo Bhattacharya, Andrew J. Copp, Mary Dickinson, Nicholas D. E. Greene, Mark Henkelman, Monica Justice, Timothy Mohun, Stephen A. Murray, Erwin Pauws, Michael Raess, Janet Rossant, Tom Weaver, David West
    Disease Models & Mechanisms 2013 6: 571-579; doi: 10.1242/dmm.011833

Review

  • Open Access
    Caught in the act: revealing the metastatic process by live imaging
    Miriam R. Fein, Mikala Egeblad
    Disease Models & Mechanisms 2013 6: 580-593; doi: 10.1242/dmm.009282

Research Articles

  • Open Access
    Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model
    Brook T. Chernet, Michael Levin
    Disease Models & Mechanisms 2013 6: 595-607; doi: 10.1242/dmm.010835
  • Open Access
    Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich’s ataxia
    Aurore Hick, Marie Wattenhofer-Donzé, Satyan Chintawar, Philippe Tropel, Jodie P. Simard, Nadège Vaucamps, David Gall, Laurie Lambot, Cécile André, Laurence Reutenauer, Myriam Rai, Marius Teletin, Nadia Messaddeq, Serge N. Schiffmann, Stéphane Viville, Christopher E. Pearson, Massimo Pandolfo, Hélène Puccio
    Disease Models & Mechanisms 2013 6: 608-621; doi: 10.1242/dmm.010900
  • Open Access
    Functional and histopathological identification of the respiratory failure in a DMSXL transgenic mouse model of myotonic dystrophy
    Petrica-Adrian Panaite, Thierry Kuntzer, Geneviève Gourdon, Johannes Alexander Lobrinus, Ibtissam Barakat-Walter
    Disease Models & Mechanisms 2013 6: 622-631; doi: 10.1242/dmm.010512
  • Open Access
    Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart
    Alejandro Lencinas, Danny C. Chhun, Kelvin P. Dan, Kristen D. Ross, Elizabeth A. Hoover, Parker B. Antin, Raymond B. Runyan
    Disease Models & Mechanisms 2013 6: 632-642; doi: 10.1242/dmm.010595
  • Open Access
    A new and clinically relevant murine model of solid-organ transplant aspergillosis
    Susanne Herbst, Anand Shah, Martin Carby, Gary Chusney, Naresh Kikkeri, Anthony Dorling, Elaine Bignell, Sunil Shaunak, Darius Armstrong-James
    Disease Models & Mechanisms 2013 6: 643-651; doi: 10.1242/dmm.010330
  • Open Access
    Generation and validation of a zebrafish model of EAST (epilepsy, ataxia, sensorineural deafness and tubulopathy) syndrome
    Fahad Mahmood, Monika Mozere, Anselm A. Zdebik, Horia C. Stanescu, Jonathan Tobin, Philip L. Beales, Robert Kleta, Detlef Bockenhauer, Claire Russell
    Disease Models & Mechanisms 2013 6: 652-660; doi: 10.1242/dmm.009480
  • Open Access
    In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1–Rok–Myosin-II and JNK signalling
    Peytee Khoo, Kirsten Allan, Lee Willoughby, Anthony M. Brumby, Helena E. Richardson
    Disease Models & Mechanisms 2013 6: 661-678; doi: 10.1242/dmm.010066
  • Open Access
    Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis
    Xue Mei, Shu Wu, Alexander G. Bassuk, Diane C. Slusarski
    Disease Models & Mechanisms 2013 6: 679-688; doi: 10.1242/dmm.010793
  • Open Access
    Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium
    Astrid G. Petzoldt, Eva Maria Gleixner, Arianna Fumagalli, Thomas Vaccari, Matias Simons
    Disease Models & Mechanisms 2013 6: 689-700; doi: 10.1242/dmm.010660
  • Open Access
    Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock
    Kiran K. Nandra, Massimo Collino, Mara Rogazzo, Roberto Fantozzi, Nimesh S. A. Patel, Christoph Thiemermann
    Disease Models & Mechanisms 2013 6: 701-709; doi: 10.1242/dmm.011353
  • Open Access
    An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias
    Cristina Mirantes, Núria Eritja, Maria Alba Dosil, Maria Santacana, Judit Pallares, Sónia Gatius, Laura Bergadà, Oscar Maiques, Xavier Matias-Guiu, Xavier Dolcet
    Disease Models & Mechanisms 2013 6: 710-720; doi: 10.1242/dmm.011445
  • Open Access
    Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis
    Patricia S. Estes, Scott G. Daniel, Abigail P. Mccallum, Ashley V. Boehringer, Alona S. Sukhina, Rebecca A. Zwick, Daniela C. Zarnescu
    Disease Models & Mechanisms 2013 6: 721-733; doi: 10.1242/dmm.010710
  • Open Access
    Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia
    Manivannan Subramanian, Suman Kumar Metya, Sufia Sadaf, Satish Kumar, Dominik Schwudke, Gaiti Hasan
    Disease Models & Mechanisms 2013 6: 734-744; doi: 10.1242/dmm.010017
  • Open Access
    Sepsis otopathy: experimental sepsis leads to significant hearing impairment due to apoptosis and glutamate excitotoxicity in murine cochlea
    Joachim Schmutzhard, Rudolf Glueckert, Christian Pritz, Michael J. F. Blumer, Mario Bitsche, Peter Lackner, Manfred Fille, Herbert Riechelmann, Matthias Harkamp, Thongrong Sitthisak, Annelies Schrott-Fischer
    Disease Models & Mechanisms 2013 6: 745-754; doi: 10.1242/dmm.011205
  • Open Access
    A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation
    Jehangir N. Ahmed, Radiya G. Ali, Nicholas Warr, Heather M. Wilson, Helen M. Bellchambers, Kristen S. Barratt, Amelia J. Thompson, Ruth M. Arkell
    Disease Models & Mechanisms 2013 6: 755-767; doi: 10.1242/dmm.011668
  • Open Access
    From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome
    Neus Martínez-Abadías, Greg Holmes, Talia Pankratz, Yingli Wang, Xueyan Zhou, Ethylin Wang Jabs, Joan T. Richtsmeier
    Disease Models & Mechanisms 2013 6: 768-779; doi: 10.1242/dmm.010397
  • Open Access
    Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease
    Laurent P. Bogdanik, James N. Sleigh, Cong Tian, Mark E. Samuels, Karen Bedard, Kevin L. Seburn, Robert W. Burgess
    Disease Models & Mechanisms 2013 6: 780-792; doi: 10.1242/dmm.010942
  • Open Access
    A necrotic stimulus is required to maximize matrix-mediated myogenesis in mice
    Drew Kuraitis, Maria Grazia Berardinelli, Erik J. Suuronen, Antonio Musarò
    Disease Models & Mechanisms 2013 6: 793-801; doi: 10.1242/dmm.011072
  • Open Access
    H. pylori virulence factor CagA increases intestinal cell proliferation by Wnt pathway activation in a transgenic zebrafish model
    James T. Neal, Tracy S. Peterson, Michael L. Kent, Karen Guillemin
    Disease Models & Mechanisms 2013 6: 802-810; doi: 10.1242/dmm.011163
  • Open Access
    Osteoarticular tissue infection and development of skeletal pathology in murine brucellosis
    Diogo M. Magnani, Elizabeth T. Lyons, Toni S. Forde, Mohammed T. Shekhani, Vyacheslav A. Adarichev, Gary A. Splitter
    Disease Models & Mechanisms 2013 6: 811-818; doi: 10.1242/dmm.011056

Research Reports

  • Open Access
    Behavioral abnormalities and Parkinson’s-like histological changes resulting from Id2 inactivation in mice
    Matthew C. Havrda, Brenton R. Paolella, Nora M. Ward, Kathryn B. Holroyd
    Disease Models & Mechanisms 2013 6: 819-827; doi: 10.1242/dmm.010041
  • Open Access
    piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice
    Rongbo Li, Yuan Zhuang, Min Han, Tian Xu, Xiaohui Wu
    Disease Models & Mechanisms 2013 6: 828-833; doi: 10.1242/dmm.010827
  • Open Access
    The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q
    Johan Lindqvist, Hiroyuki Iwamoto, Gonzalo Blanco, Julien Ochala
    Disease Models & Mechanisms 2013 6: 834-840; doi: 10.1242/dmm.011155

Resource Articles

  • Open Access
    Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system
    Michiel van der Vaart, Joost J. van Soest, Herman P. Spaink, Annemarie H. Meijer
    Disease Models & Mechanisms 2013 6: 841-854; doi: 10.1242/dmm.010843
  • Open Access
    An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides
    Cleopatra Kozlowski, Surinder Jeet, Joseph Beyer, Steve Guerrero, Justin Lesch, Xiaoting Wang, Jason DeVoss, Lauri Diehl
    Disease Models & Mechanisms 2013 6: 855-865; doi: 10.1242/dmm.011759
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  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
  • Open Access

    Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

    Paco López-Cuevas, Luke Deane, Yushi Yang, Chrissy L Hammond, Erika Kague
    PDF
  • Open Access

    Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

    Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
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Monica Justice bids farewell to DMM

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Modelling Joubert syndrome patient-derived mutations in C. elegans

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Interview – Karen Lange

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