Disease Models & Mechanisms: 6 (3)

May 1, 2013; 6 (3)

In This Issue

Open Access
Bioelectric signals: a diagnostic marker for cancer
Disease Models & Mechanisms 2013 6: 555
Open Access
Respiratory failure in myotonic dystrophy 1
Disease Models & Mechanisms 2013 6: 555
Open Access
New mouse model for Parkinson’s disease
Disease Models & Mechanisms 2013 6: 555
Open Access
Innate immunity: clues from zebrafish
Disease Models & Mechanisms 2013 6: 555
Open Access
EPO pre-treatment for haemorrhagic shock
Disease Models & Mechanisms 2013 6: 555
Open Access
Role of CagA in H. pylori gastric cancer
Disease Models & Mechanisms 2013 6: 555-556;
Open Access
Patient-derived iPSCs: a new model for Friedreich’s ataxia
Disease Models & Mechanisms 2013 6: 556
Open Access
Biomaterial promotes muscle cell regeneration in vivo
Disease Models & Mechanisms 2013 6: 556
Open Access
An inducible knockout mouse model for PTEN cancers
Disease Models & Mechanisms 2013 6: 556

Editorials

Open Access
Provoking progress: a new chapter
Vivian Siegel Founding Editor-in-Chief

Disease Models & Mechanisms 2013 6: 557-558; doi: 10.1242/dmm.012419
Open Access
Bridging the gap between basic and applied biology: towards preclinical translation
Ross L. Cagan, Monica J. Justice, George F. Tidmarsh

Disease Models & Mechanisms 2013 6: 559-561; doi: 10.1242/dmm.012450
Open Access
Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice
Timothy Mohun, David J. Adams, Richard Baldock, Shoumo Bhattacharya, Andrew J. Copp, Myriam Hemberger, Corinne Houart, Matt E. Hurles, Elizabeth Robertson, James C. Smith, Tom Weaver, Wolfgang Weninger

Disease Models & Mechanisms 2013 6: 562-566; doi: 10.1242/dmm.011957

A Model For Life

Open Access
Bench to bedside with fruit flies: an interview with Ross Cagan
Disease Models & Mechanisms 2013 6: 567-569; doi: 10.1242/dmm.012443

Special Article

Open Access
Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening
David Adams, Richard Baldock, Shoumo Bhattacharya, Andrew J. Copp, Mary Dickinson, Nicholas D. E. Greene, Mark Henkelman, Monica Justice, Timothy Mohun, Stephen A. Murray, Erwin Pauws, Michael Raess, Janet Rossant, Tom Weaver, David West

Disease Models & Mechanisms 2013 6: 571-579; doi: 10.1242/dmm.011833

Review

Open Access
Caught in the act: revealing the metastatic process by live imaging
Miriam R. Fein, Mikala Egeblad

Disease Models & Mechanisms 2013 6: 580-593; doi: 10.1242/dmm.009282

Research Articles

Open Access
Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model
Brook T. Chernet, Michael Levin

Disease Models & Mechanisms 2013 6: 595-607; doi: 10.1242/dmm.010835
Open Access
Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich’s ataxia
Aurore Hick, Marie Wattenhofer-Donzé, Satyan Chintawar, Philippe Tropel, Jodie P. Simard, Nadège Vaucamps, David Gall, Laurie Lambot, Cécile André, Laurence Reutenauer, Myriam Rai, Marius Teletin, Nadia Messaddeq, Serge N. Schiffmann, Stéphane Viville, Christopher E. Pearson, Massimo Pandolfo, Hélène Puccio

Disease Models & Mechanisms 2013 6: 608-621; doi: 10.1242/dmm.010900
Open Access
Functional and histopathological identification of the respiratory failure in a DMSXL transgenic mouse model of myotonic dystrophy
Petrica-Adrian Panaite, Thierry Kuntzer, Geneviève Gourdon, Johannes Alexander Lobrinus, Ibtissam Barakat-Walter

Disease Models & Mechanisms 2013 6: 622-631; doi: 10.1242/dmm.010512
Open Access
Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart
Alejandro Lencinas, Danny C. Chhun, Kelvin P. Dan, Kristen D. Ross, Elizabeth A. Hoover, Parker B. Antin, Raymond B. Runyan

Disease Models & Mechanisms 2013 6: 632-642; doi: 10.1242/dmm.010595
Open Access
A new and clinically relevant murine model of solid-organ transplant aspergillosis
Susanne Herbst, Anand Shah, Martin Carby, Gary Chusney, Naresh Kikkeri, Anthony Dorling, Elaine Bignell, Sunil Shaunak, Darius Armstrong-James

Disease Models & Mechanisms 2013 6: 643-651; doi: 10.1242/dmm.010330
Open Access
Generation and validation of a zebrafish model of EAST (epilepsy, ataxia, sensorineural deafness and tubulopathy) syndrome
Fahad Mahmood, Monika Mozere, Anselm A. Zdebik, Horia C. Stanescu, Jonathan Tobin, Philip L. Beales, Robert Kleta, Detlef Bockenhauer, Claire Russell

Disease Models & Mechanisms 2013 6: 652-660; doi: 10.1242/dmm.009480
Open Access
In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1–Rok–Myosin-II and JNK signalling
Peytee Khoo, Kirsten Allan, Lee Willoughby, Anthony M. Brumby, Helena E. Richardson

Disease Models & Mechanisms 2013 6: 661-678; doi: 10.1242/dmm.010066
Open Access
Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis
Xue Mei, Shu Wu, Alexander G. Bassuk, Diane C. Slusarski

Disease Models & Mechanisms 2013 6: 679-688; doi: 10.1242/dmm.010793
Open Access
Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium
Astrid G. Petzoldt, Eva Maria Gleixner, Arianna Fumagalli, Thomas Vaccari, Matias Simons

Disease Models & Mechanisms 2013 6: 689-700; doi: 10.1242/dmm.010660
Open Access
Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock
Kiran K. Nandra, Massimo Collino, Mara Rogazzo, Roberto Fantozzi, Nimesh S. A. Patel, Christoph Thiemermann

Disease Models & Mechanisms 2013 6: 701-709; doi: 10.1242/dmm.011353
Open Access
An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias
Cristina Mirantes, Núria Eritja, Maria Alba Dosil, Maria Santacana, Judit Pallares, Sónia Gatius, Laura Bergadà, Oscar Maiques, Xavier Matias-Guiu, Xavier Dolcet

Disease Models & Mechanisms 2013 6: 710-720; doi: 10.1242/dmm.011445
Open Access
Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis
Patricia S. Estes, Scott G. Daniel, Abigail P. Mccallum, Ashley V. Boehringer, Alona S. Sukhina, Rebecca A. Zwick, Daniela C. Zarnescu

Disease Models & Mechanisms 2013 6: 721-733; doi: 10.1242/dmm.010710
Open Access
Altered lipid homeostasis in Drosophila InsP₃ receptor mutants leads to obesity and hyperphagia
Manivannan Subramanian, Suman Kumar Metya, Sufia Sadaf, Satish Kumar, Dominik Schwudke, Gaiti Hasan

Disease Models & Mechanisms 2013 6: 734-744; doi: 10.1242/dmm.010017
Open Access
Sepsis otopathy: experimental sepsis leads to significant hearing impairment due to apoptosis and glutamate excitotoxicity in murine cochlea
Joachim Schmutzhard, Rudolf Glueckert, Christian Pritz, Michael J. F. Blumer, Mario Bitsche, Peter Lackner, Manfred Fille, Herbert Riechelmann, Matthias Harkamp, Thongrong Sitthisak, Annelies Schrott-Fischer

Disease Models & Mechanisms 2013 6: 745-754; doi: 10.1242/dmm.011205
Open Access
A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation
Jehangir N. Ahmed, Radiya G. Ali, Nicholas Warr, Heather M. Wilson, Helen M. Bellchambers, Kristen S. Barratt, Amelia J. Thompson, Ruth M. Arkell

Disease Models & Mechanisms 2013 6: 755-767; doi: 10.1242/dmm.011668
Open Access
From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome
Neus Martínez-Abadías, Greg Holmes, Talia Pankratz, Yingli Wang, Xueyan Zhou, Ethylin Wang Jabs, Joan T. Richtsmeier

Disease Models & Mechanisms 2013 6: 768-779; doi: 10.1242/dmm.010397
Open Access
Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease
Laurent P. Bogdanik, James N. Sleigh, Cong Tian, Mark E. Samuels, Karen Bedard, Kevin L. Seburn, Robert W. Burgess

Disease Models & Mechanisms 2013 6: 780-792; doi: 10.1242/dmm.010942
Open Access
A necrotic stimulus is required to maximize matrix-mediated myogenesis in mice
Drew Kuraitis, Maria Grazia Berardinelli, Erik J. Suuronen, Antonio Musarò

Disease Models & Mechanisms 2013 6: 793-801; doi: 10.1242/dmm.011072
Open Access
H. pylori virulence factor CagA increases intestinal cell proliferation by Wnt pathway activation in a transgenic zebrafish model
James T. Neal, Tracy S. Peterson, Michael L. Kent, Karen Guillemin

Disease Models & Mechanisms 2013 6: 802-810; doi: 10.1242/dmm.011163
Open Access
Osteoarticular tissue infection and development of skeletal pathology in murine brucellosis
Diogo M. Magnani, Elizabeth T. Lyons, Toni S. Forde, Mohammed T. Shekhani, Vyacheslav A. Adarichev, Gary A. Splitter

Disease Models & Mechanisms 2013 6: 811-818; doi: 10.1242/dmm.011056

Research Reports

Open Access
Behavioral abnormalities and Parkinson’s-like histological changes resulting from Id2 inactivation in mice
Matthew C. Havrda, Brenton R. Paolella, Nora M. Ward, Kathryn B. Holroyd

Disease Models & Mechanisms 2013 6: 819-827; doi: 10.1242/dmm.010041
Open Access
piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice
Rongbo Li, Yuan Zhuang, Min Han, Tian Xu, Xiaohui Wu

Disease Models & Mechanisms 2013 6: 828-833; doi: 10.1242/dmm.010827
Open Access
The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4^L342Q
Johan Lindqvist, Hiroyuki Iwamoto, Gonzalo Blanco, Julien Ochala

Disease Models & Mechanisms 2013 6: 834-840; doi: 10.1242/dmm.011155

Resource Articles

Open Access
Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system
Michiel van der Vaart, Joost J. van Soest, Herman P. Spaink, Annemarie H. Meijer

Disease Models & Mechanisms 2013 6: 841-854; doi: 10.1242/dmm.010843
Open Access
An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides
Cleopatra Kozlowski, Surinder Jeet, Joseph Beyer, Steve Guerrero, Justin Lesch, Xiaoting Wang, Jason DeVoss, Lauri Diehl

Disease Models & Mechanisms 2013 6: 855-865; doi: 10.1242/dmm.011759

This issue

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Open Access

Altered in vitro muscle differentiation in X-linked myopathy with excessive autophagy (XMEA)

Stephanie A. Fernandes, Camila F. Almeida, Lucas S. Souza, Monize Lazar, Paula Onofre-Oliveira, Guilherme L. Yamamoto, Letícia Nogueira, Letícia Y. Tasaki, Rafaela R. Cardoso, Rita C. M. Pavanello, Helga C. A. Silva, Merari F. R. Ferrari, Anne Bigot, Vincent Mouly, Mariz Vainzof

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Open Access

Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes

Phillipe D. O'Brien, Kai Guo, Stephanie A. Eid, Amy E. Rumora, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson, Junguk Hur, Eva L. Feldman

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Open Access

A comparison of the bone and growth phenotype of mdx, mdx:cmah^−/− and mdx:utrn^+/− murine models with the C57BL10 wildtype mouse

C. L. Wood, K. J. Suchaki, R. van 't Hof, W. P. Cawthorn, S. Dillon, V. Straub, S. C. Wong, S. F. Ahmed, C. Farquharson

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Open Access

Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger

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Open Access

A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries

Omkara Lakshmi Veeranki, Zhimin Tong, Alicia Mejia, Anuj Verma, Riham Katkhuda, Roland Bassett, Tae-Beom Kim, Jing Wang, Wenhua Lang, Barbara Mino, Luisa Solis, Charles Kingsley, William Norton, Ramesh Tailor, Ji Yuan Wu, Sunil Krishnan, Steven H. Lin, Mariela Blum, Wayne Hofstetter, Jaffer Ajani, Scott Kopetz, Dipen Maru

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Other journals from The Company of Biologists

First person — Andrew Scott Emmert and Eri Iwasawa

In an interview, first authors Andrew Scott Emmert and Eri Iwasawa discuss their new paper on impaired CSF flow and neural differentiation in a rat model of hydrocephalus, their research process and plans for the future.

Editor’s choice — Drug repurposing screening for rare diseases

Ethan Perlstein and colleagues present two back-to-back articles. In the first, they describe how the diabetic neuropathy drug palrestat can ameliorate PMM2-CDG. The second identifies the FDA-approved aripiprazole as a clinical candidate for treating NGLY1 deficiency.

Resource — SILAC-based quantitative proteomics using mass spectrometry quantifies endoplasmic reticulum stress in whole HeLa cells

Read Murgia et al.’s new resource article describing a SILAC-based proteomics approach to quantify the unfolded protein response.

Review Commons launches

We're excited to be an affiliate journal for Review Commons, the ASAPbio/EMBO platform for high-quality journal-independent peer-review in the life sciences, which went live on 09 December.

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