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Review
Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction
Bianca Jupp, Daniele Caprioli, Jeffrey W. Dalley
Disease Models & Mechanisms 2013 6: 302-311; doi: 10.1242/dmm.010934
Bianca Jupp
1Behavioural and Cognitive Neurosciences Institute and The Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
2Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
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Daniele Caprioli
1Behavioural and Cognitive Neurosciences Institute and The Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
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Jeffrey W. Dalley
1Behavioural and Cognitive Neurosciences Institute and The Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
3Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK
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  • For correspondence: jwd20@cam.ac.uk
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Abstract

Impulsivity describes the tendency of an individual to act prematurely without foresight and is associated with a number of neuropsychiatric co-morbidities, including drug addiction. As such, there is increasing interest in the neurobiological mechanisms of impulsivity, as well as the genetic and environmental influences that govern the expression of this behaviour. Tests used on rodent models of impulsivity share strong parallels with tasks used to assess this trait in humans, and studies in both suggest a crucial role of monoaminergic corticostriatal systems in the expression of this behavioural trait. Furthermore, rodent models have enabled investigation of the causal relationship between drug abuse and impulsivity. Here, we review the use of rodent models of impulsivity for investigating the mechanisms involved in this trait, and how these mechanisms could contribute to the pathogenesis of addiction.

Footnotes

  • COMPETING INTERESTS: None to declare.

  • © 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Review
Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction
Bianca Jupp, Daniele Caprioli, Jeffrey W. Dalley
Disease Models & Mechanisms 2013 6: 302-311; doi: 10.1242/dmm.010934
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Review
Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction
Bianca Jupp, Daniele Caprioli, Jeffrey W. Dalley
Disease Models & Mechanisms 2013 6: 302-311; doi: 10.1242/dmm.010934

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    • Abstract
    • Defining impulsivity: a human trait
    • Neurobiology of impulsivity
    • Animal models of trait-like impulsivity
    • Trait-like impulsivity in rodents: a vulnerability marker of addiction
    • Implications for addiction
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