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  Open access

March, 2013; 6 (2)

In This Issue

  • Open Access
    Deafness in distal renal tubular acidosis
    Disease Models & Mechanisms 2013 6: 279
  • Open Access
    Parasite-infected rats: insights into anxiety disorders
    Disease Models & Mechanisms 2013 6: 279
  • Open Access
    Zebrafish liver-cancer model
    Disease Models & Mechanisms 2013 6: 279
  • Open Access
    GREMLIN2 and atrial fibrillation
    Disease Models & Mechanisms 2013 6: 279
  • Open Access
    Sudden infant death syndrome: clues from mice
    Disease Models & Mechanisms 2013 6: 279
  • Open Access
    Stress-induced atherosclerotic lesion model
    Disease Models & Mechanisms 2013 6: 279

Clinical Puzzle

  • Open Access
    The challenge of cholangiocarcinoma: dissecting the molecular mechanisms of an insidious cancer
    Abigail Zabron, Robert J. Edwards, Shahid A. Khan
    Disease Models & Mechanisms 2013 6: 281-292; doi: 10.1242/dmm.010561

Special Article

  • Open Access
    The ‘39 steps’: an algorithm for performing statistical analysis of data on energy intake and expenditure
    John R. Speakman, Quinn Fletcher, Lobke Vaanholt
    Disease Models & Mechanisms 2013 6: 293-301; doi: 10.1242/dmm.009860

Reviews

  • Open Access
    Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction
    Bianca Jupp, Daniele Caprioli, Jeffrey W. Dalley
    Disease Models & Mechanisms 2013 6: 302-311; doi: 10.1242/dmm.010934
  • Open Access
    Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
    Galina Dragneva, Petra Korpisalo, Seppo Ylä-Herttuala
    Disease Models & Mechanisms 2013 6: 312-322; doi: 10.1242/dmm.010413

Research Articles

  • Open Access
    A new murine model of stress-induced complex atherosclerotic lesions
    Amir H. Najafi, Nima Aghili, Justin U. Tilan, James A. Andrews, XinZhi Peng, Roberta M. Lassance-Soares, Subeena Sood, Lee O. Alderman, Ken Abe, Lijun Li, Frank D. Kolodgie, Renu Virmani, Zofia Zukowska, Stephen E. Epstein, Mary Susan Burnett
    Disease Models & Mechanisms 2013 6: 323-331; doi: 10.1242/dmm.009977
  • Open Access
    Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm
    Iris I. Müller, David B. Melville, Vineeta Tanwar, Witold M. Rybski, Amrita Mukherjee, M. Benjamin Shoemaker, Wan-Der Wang, John A. Schoenhard, Dan M. Roden, Dawood Darbar, Ela W. Knapik, Antonis K. Hatzopoulos
    Disease Models & Mechanisms 2013 6: 332-341; doi: 10.1242/dmm.010488
  • Open Access
    Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice
    Tea Blom, Mia-Lisa Schmiedt, Andrew M. Wong, Aija Kyttälä, Jarkko Soronen, Matti Jauhiainen, Jaana Tyynelä, Jonathan D. Cooper, Anu Jalanko
    Disease Models & Mechanisms 2013 6: 342-357; doi: 10.1242/dmm.010140
  • Open Access
    Phenotypic overlap in the contribution of individual genes to CNV pathogenicity revealed by cross-species computational analysis of single-gene mutations in humans, mice and zebrafish
    Sandra C. Doelken, Sebastian Köhler, Christopher J. Mungall, Georgios V. Gkoutos, Barbara J. Ruef, Cynthia Smith, Damian Smedley, Sebastian Bauer, Eva Klopocki, Paul N. Schofield, Monte Westerfield, Peter N. Robinson, Suzanna E. Lewis
    Disease Models & Mechanisms 2013 6: 358-372; doi: 10.1242/dmm.010322
  • Open Access
    Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma
    Damini Chand, Yasuo Yamazaki, Kristina Ruuth, Christina Schönherr, Tommy Martinsson, Per Kogner, Edward F. Attiyeh, John Maris, Olena Morozova, Marco A. Marra, Miki Ohira, Akira Nakagawara, Per-Erik Sandström, Ruth H. Palmer, Bengt Hallberg
    Disease Models & Mechanisms 2013 6: 373-382; doi: 10.1242/dmm.010348
  • Open Access
    TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3
    Raquel Espín, Francisco J. Roca, Sergio Candel, María P. Sepulcre, Juan M. González-Rosa, Francisca Alcaraz-Pérez, José Meseguer, María L. Cayuela, Nadia Mercader, Victoriano Mulero
    Disease Models & Mechanisms 2013 6: 383-396; doi: 10.1242/dmm.010249
  • Open Access
    Loss of MMP-2 in murine osteoblasts upregulates osteopontin and bone sialoprotein expression in a circuit regulating bone homeostasis
    Rebecca A. Mosig, John A. Martignetti
    Disease Models & Mechanisms 2013 6: 397-403; doi: 10.1242/dmm.007914
  • Open Access
    Knockdown of Pnpla6 protein results in motor neuron defects in zebrafish
    Yang Song, Molin Wang, Fei Mao, Ming Shao, Baochang Zhao, Zhen Song, Changshun Shao, Yaoqin Gong
    Disease Models & Mechanisms 2013 6: 404-413; doi: 10.1242/dmm.009688
  • Open Access
    A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors
    Zhen Li, Weiling Zheng, Zhengyuan Wang, Zhiqiang Zeng, Huiqing Zhan, Caixia Li, Li Zhou, Chuan Yan, Jan M. Spitsbergen, Zhiyuan Gong
    Disease Models & Mechanisms 2013 6: 414-423; doi: 10.1242/dmm.010462
  • Open Access
    An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples
    Eleonora Ciarlo, Sara Massone, Ilaria Penna, Mario Nizzari, Arianna Gigoni, Giorgio Dieci, Claudio Russo, Tullio Florio, Ranieri Cancedda, Aldo Pagano
    Disease Models & Mechanisms 2013 6: 424-433; doi: 10.1242/dmm.009761
  • Open Access
    Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear
    Beatriz Lorente-Cánovas, Neil Ingham, Elizabeth E. Norgett, Zoe J. Golder, Fiona E. Karet Frankl, Karen P. Steel
    Disease Models & Mechanisms 2013 6: 434-442; doi: 10.1242/dmm.010645
  • Open Access
    Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats
    Bethany P. Cummings, Ahmed Bettaieb, James L. Graham, Jaehyoung Kim, Fangrui Ma, Noreene Shibata, Kimber L. Stanhope, Cecilia Giulivi, Frederik Hansen, Jacob Jelsing, Niels Vrang, Mark Kowala, Michael L. Chouinard, Fawaz G. Haj, Peter J. Havel
    Disease Models & Mechanisms 2013 6: 443-456; doi: 10.1242/dmm.010421
  • Open Access
    Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats
    Daniel Donner, John P. Headrick, Jason N. Peart, Eugene F. du Toit
    Disease Models & Mechanisms 2013 6: 457-466; doi: 10.1242/dmm.010959
  • Open Access
    Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis
    Mario A. Moscarello, Helena Lei, Fabrizio G. Mastronardi, Shawn Winer, Hubert Tsui, Zhen Li, Cameron Ackerley, Li Zhang, Reinout Raijmakers, D. Denise Wood
    Disease Models & Mechanisms 2013 6: 467-478; doi: 10.1242/dmm.010520
  • Open Access
    Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge
    Cristan Herbert, Jessica S. Siegle, Alexander M. Shadie, Stina Nikolaysen, Linda Garthwaite, Nicole G. Hansbro, Paul S. Foster, Rakesh K. Kumar
    Disease Models & Mechanisms 2013 6: 479-488; doi: 10.1242/dmm.010728
  • Open Access
    A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations
    Greger Abrahamsen, Yongjun Fan, Nicholas Matigian, Gautam Wali, Bernadette Bellette, Ratneswary Sutharsan, Jyothy Raju, Stephen A. Wood, David Veivers, Carolyn M. Sue, Alan Mackay-Sim
    Disease Models & Mechanisms 2013 6: 489-502; doi: 10.1242/dmm.010884

Research Reports

  • Open Access
    A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome
    Marianne T. Neary, Timothy J. Mohun, Ross A. Breckenridge
    Disease Models & Mechanisms 2013 6: 503-507; doi: 10.1242/dmm.010587
  • Open Access
    Inflammation drives wound hyperpigmentation in zebrafish by recruiting pigment cells to sites of tissue damage
    Mathieu Lévesque, Yi Feng, Rebecca A. Jones, Paul Martin
    Disease Models & Mechanisms 2013 6: 508-515; doi: 10.1242/dmm.010371
  • Open Access
    Toxoplasma gondii infection induces dendritic retraction in basolateral amygdala accompanied by reduced corticosterone secretion
    Rupshi Mitra, Robert Morris Sapolsky, Ajai Vyas
    Disease Models & Mechanisms 2013 6: 516-520; doi: 10.1242/dmm.009928
  • Open Access
    An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery
    Lee F. Willoughby, Tanja Schlosser, Samuel A. Manning, John P. Parisot, Ian P. Street, Helena E. Richardson, Patrick O. Humbert, Anthony M. Brumby
    Disease Models & Mechanisms 2013 6: 521-529; doi: 10.1242/dmm.009985
  • Open Access
    Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1
    Brigid Orr, O. Cathal Grace, Pam Brown, Antony C. P. Riddick, Grant D. Stewart, Omar E. Franco, Simon W. Hayward, Axel A. Thomson
    Disease Models & Mechanisms 2013 6: 530-536; doi: 10.1242/dmm.010355
  • Open Access
    NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos
    Sandra Mercier, Véronique David, Leslie Ratié, Isabelle Gicquel, Sylvie Odent, Valérie Dupé
    Disease Models & Mechanisms 2013 6: 537-543; doi: 10.1242/dmm.010132

Resource Article

  • Open Access
    Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome
    Miguel G. Toscano, Per Anderson, Pilar Muñoz, Gema Lucena, Marién Cobo, Karim Benabdellah, Philip D. Gregory, Michael C. Holmes, Francisco Martin
    Disease Models & Mechanisms 2013 6: 544-554; doi: 10.1242/dmm.010652
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  • Open Access

    Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency

    Alessia Niceforo, Chiara Marioli, Fiorella Colasuonno, Stefania Petrini, Keith Massey, Marco Tartaglia, Enrico Bertini, Sandra Moreno, Claudia Compagnucci
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  • Open Access

    Genetic background modifies vulnerability to glaucoma related phenotypes in Lmx1b mutant mice

    N. G. Tolman, R. Balasubramanian, D. G. Macalinao, A. L. Kearney, K. H. MacNicoll, C. L. Montgomery, W. N. de Vries, I. J. Jackson, S. H. Cross, K. Kizhatil, K. S. Nair, S. W. M. John
    PDF
  • Open Access

    Neural crest-specific deletion of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction, and disordered breathing modelling Obstructive Sleep Apnea

    Pranidhi Baddam, Vivian Biancardi, Daniela M. Roth, Farah Eaton, Claudine Thereza-Bussolaro, Rupasri Mandal, David S. Wishart, Amy Barr, Joanna MacLean, Carlos Flores-Mir, Silvia Pagliardini, Daniel Graf
    PDF
  • Open Access

    Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

    F. W. Riemslagh, E. C. van der Toorn, R. F. M. Verhagen, A. Maas, L. W. J. Bosman, R. K. Hukema, R. Willemsen
    PDF
  • Open Access

    A muscle growth promoting treatment based on the attenuation of activin/myostatin signalling in young mice results in long-term testicular abnormalities

    Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
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