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In This Issue
Left-right patterning: where and when serotonin acts
Disease Models & Mechanisms 2013 6: 1
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The left-right (LR) asymmetry of internal organs is established during embryogenesis. Failure of LR patterning causes serious birth defects, so it is important to understand how it is initiated. Vandenberg et al. performed experiments in Xenopus embryos to distinguish between two theoretical models explaining the initiation of LR patterning – the EARLY model, which proposes that serotonin acts in right-side blastomeres to initiate the cascade of asymmetric gene expression, and the LATE model, which proposes that, during neurulation, serotonin induces cilia that later break embryonic symmetry. The researchers show that preventing serotonin signalling in blastomeres that do not contribute to cilia randomises asymmetry, and that asymmetric genes become expressed even in explants without cilia. Their results uniformly support the EARLY model, a finding that could affect our understanding of the aetiology of several birth defects. Page 261

  • Written by Jane Bradbury. © 2012. Published by The Company of Biologists Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Monica Justice bids farewell to DMM

In her farewell Editorial, outgoing Editor-in-Chief Monica Justice reminds us of the past half-decade of growth and of DMM's commitment to support the disease modelling community, concluding, “The knowledge and experience I gained during my time as Senior Editor and EiC at DMM is invaluable: working within a not-for-profit community publishing environment is a joy.”


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Modelling Joubert syndrome patient-derived mutations in C. elegans

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