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January 1, 2013; 6 (1)

In This Issue

Journal Club

A Model For Life

Clinical Puzzle

Reviews

Research Articles

Research Report

Resource Article

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Editor’s choice - Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity

From ‘Hematopoietic depletion of E(Pc)/Tip60 induces precocious lamellocyte differentiation and tumor formation’

Using Drosophila as a low-complexity model for human myeloproliferative neoplasms, Erika Bach and team identified a conserved mechanism by which the Tip60 lysine acetyltransferase acts as a tumor suppressor by repressing JAK protein expression in a histone-independent manner.

From 'Modeling ID and ASD in Drosophila – from (sub)cellular defects to aberrant behavior'

This Review summarizes some of the exciting work that has used Drosophila as a model for the ever-expanding field of intellectual disability and autism spectrum disorders. Annette Schenck and team highlight disease-relevant assays, emerging themes and future challenges.

From ‘Effects of diet and exercise intervention on obesity, NAFLD-associated hepatic histological findings and lipid-metabolism regulation in juvenile rats fed a control diet or HFD over 11 weeks’

The beneficial effects of exercise against diet-induced early obesity and NAFLD are mediated by its capacity to modulate intestinal microbiota composition and functionality, restore lipid metabolism and prevent disruption of the gut-liver axis, show Sonia Sánchez-Campos and colleagues.

First Person interviews

First authors Susan Motch Perrine and Meng Wu, Alessandro Bailetti, Tuba Sural-Fehr and Scott Collum

Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with Susan Motch Perrine and Meng Wu, Alessandro Bailetti, Tuba Sural-Fehr and Scott Collum.

Don't miss your chance to attend our DMM Journal Meeting in Boston. Deadline to apply is 21 June 2019. Join organisers Monica Justice, Nancy Speck, Paresh Vyas and Leonard Zon.

Call for papers – A guide to using neuromuscular disease models for basic and preclinical studies

Call for papers – A guide to using neuromuscular disease models for basic and preclinical studies

We invite you to submit original research for a Special Collection focused on neuromuscular disease models, edited by Annemieke Aartsma-Rus, James Dowling and Maaike van Putten. The collection will showcase studies on the dysregulation of pathways, disease progression, approaches to treat and modify disease course in animal models, technologies for studying muscle pathophysiology and regeneration, and advances in the development of suitable in vitro and in vivo models. Deadline extended to 1 July 2019.

Meet the preLighters: an interview with Tessa Sinnige

preLighter Tessa Sinnige

Tessa Sinnige is a postdoctoral fellow who recently moved to Northwestern University, USA from the University of Cambridge. In her research she studies the mechanisms of protein aggregation using C. elegans as a model. We caught up with Tessa to discuss about her science, postdoc life, preprints and her experience with preLights.

Catch up with recent preLights selected for the translational biology community.