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  Open access

January, 2013; 6 (1)

In This Issue

  • Open Access
    Bmi1, medulloblastoma and regenerative therapy
    Disease Models & Mechanisms 2013 6: 1
  • Open Access
    Multipurpose cell-based fascin bioassay
    Disease Models & Mechanisms 2013 6: 1
  • Open Access
    Ang-1, lung development and congenital diaphragmatic hernia
    Disease Models & Mechanisms 2013 6: 1
  • Open Access
    Zebrafish model for diseases caused by ER stress
    Disease Models & Mechanisms 2013 6: 1
  • Open Access
    Myotonic dystrophy: new clues from flies
    Disease Models & Mechanisms 2013 6: 1
  • Open Access
    Left-right patterning: where and when serotonin acts
    Disease Models & Mechanisms 2013 6: 1

Journal Club

  • Open Access
    Modelling how initiating and transforming oncogenes cooperate to produce a leukaemic cell state
    Simon E. Richardson
    Disease Models & Mechanisms 2013 6: 3-5; doi: 10.1242/dmm.011288

A Model For Life

  • Open Access
    Driving change in tuberculosis research: an interview with Anne O’Garra
    Disease Models & Mechanisms 2013 6: 6-8; doi: 10.1242/dmm.011429

Clinical Puzzle

  • Open Access
    Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis
    Jonathan A. Kropski, William E. Lawson, Lisa R. Young, Timothy S. Blackwell
    Disease Models & Mechanisms 2013 6: 9-17; doi: 10.1242/dmm.010736

Reviews

  • Open Access
    The armadillo: a model for the neuropathy of leprosy and potentially other neurodegenerative diseases
    Rahul Sharma, Ramanuj Lahiri, David M. Scollard, Maria Pena, Diana L. Williams, Linda B. Adams, John Figarola, Richard W. Truman
    Disease Models & Mechanisms 2013 6: 19-24; doi: 10.1242/dmm.010215
  • Open Access
    Cellular and molecular mechanisms of muscle atrophy
    Paolo Bonaldo, Marco Sandri
    Disease Models & Mechanisms 2013 6: 25-39; doi: 10.1242/dmm.010389
  • Open Access
    Learning from a paradox: recent insights into Fanconi anaemia through studying mouse models
    Sietske T. Bakker, Johan P. de Winter, Hein te Riele
    Disease Models & Mechanisms 2013 6: 40-47; doi: 10.1242/dmm.009795

Research Articles

  • Open Access
    Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation
    Hourinaz Behesti, Heeta Bhagat, Adrian M. Dubuc, Michael D. Taylor, Silvia Marino
    Disease Models & Mechanisms 2013 6: 49-63; doi: 10.1242/dmm.009506
  • Open Access
    Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish
    Ricardo Pineda, Christine E. Beattie, Charles W. Hall
    Disease Models & Mechanisms 2013 6: 64-71; doi: 10.1242/dmm.009423
  • Open Access
    Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice
    Coralie Fassier, Anne Tarrade, Leticia Peris, Sabrina Courageot, Philippe Mailly, Cécile Dalard, Stéphanie Delga, Natacha Roblot, Julien Lefèvre, Didier Job, Jamilé Hazan, Patrick A. Curmi, Judith Melki
    Disease Models & Mechanisms 2013 6: 72-83; doi: 10.1242/dmm.008946
  • Open Access
    Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia
    Patricia P. Jumbo-Lucioni, Marquise L. Hopson, Darwin Hang, Yongliang Liang, Dean P. Jones, Judith L. Fridovich-Keil
    Disease Models & Mechanisms 2013 6: 84-94; doi: 10.1242/dmm.010207
  • Open Access
    A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation
    Jaime Chu, Alexander Mir, Ningguo Gao, Sabrina Rosa, Christopher Monson, Vandana Sharma, Richard Steet, Hudson H. Freeze, Mark A. Lehrman, Kirsten C. Sadler
    Disease Models & Mechanisms 2013 6: 95-105; doi: 10.1242/dmm.010116
  • Open Access
    Timing and expression of the angiopoietin-1–Tie-2 pathway in murine lung development and congenital diaphragmatic hernia
    Adrienne Grzenda, John Shannon, Jason Fisher, Marc S. Arkovitz
    Disease Models & Mechanisms 2013 6: 106-114; doi: 10.1242/dmm.008821
  • Open Access
    Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice
    Dylan T. Jones, Tanguy Lechertier, Louise E. Reynolds, Richard Mitter, Stephen D. Robinson, Catherine B. Kirn-Safran, Kairbaan M. Hodivala-Dilke
    Disease Models & Mechanisms 2013 6: 115-124; doi: 10.1242/dmm.009183
  • Open Access
    Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγnull mice engrafted with human peripheral blood mononuclear cells
    Thomas Nolte, Maryam Zadeh-Khorasani, Orkhan Safarov, Franziska Rueff, Rita Varga, Nadja Herbach, Rüdiger Wanke, Andreas Wollenberg, Thomas Mueller, Roswitha Gropp, Eckhard Wolf, Matthias Siebeck
    Disease Models & Mechanisms 2013 6: 125-134; doi: 10.1242/dmm.009167
  • Open Access
    Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology
    Kelly R. Monk, Matthew G. Voas, Clara Franzini-Armstrong, Ian S. Hakkinen, William S. Talbot
    Disease Models & Mechanisms 2013 6: 135-145; doi: 10.1242/dmm.009217
  • Open Access
    Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses
    Jason R. Goldsmith, Jordan L. Cocchiaro, John F. Rawls, Christian Jobin
    Disease Models & Mechanisms 2013 6: 146-159; doi: 10.1242/dmm.009852
  • Open Access
    Age-related changes in core body temperature and activity in triple-transgenic Alzheimer’s disease (3xTgAD) mice
    Elysse M. Knight, Timothy M. Brown, Sarah Gümüsgöz, Jennifer C. M. Smith, Elizabeth J. Waters, Stuart M. Allan, Catherine B. Lawrence
    Disease Models & Mechanisms 2013 6: 160-170; doi: 10.1242/dmm.010173
  • Open Access
    Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice
    Lilia Zurkovsky, Evgeny Bychkov, Elviche L. Tsakem, Carley Siedlecki, Randy D. Blakely, Eugenia V. Gurevich
    Disease Models & Mechanisms 2013 6: 171-183; doi: 10.1242/dmm.010363
  • Open Access
    Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model
    Beatriz Llamusi, Ariadna Bargiela, Juan M. Fernandez-Costa, Amparo Garcia-Lopez, Raffaella Klima, Fabian Feiguin, Ruben Artero
    Disease Models & Mechanisms 2013 6: 184-196; doi: 10.1242/dmm.009563
  • Open Access
    Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury
    Kitipong Uaesoontrachoon, Dimuthu K. Wasgewatte Wijesinghe, Eleanor J. Mackie, Charles N. Pagel
    Disease Models & Mechanisms 2013 6: 197-205; doi: 10.1242/dmm.009993
  • Open Access
    A yeast model for amyloid-β aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity
    Fabien D’Angelo, Hélène Vignaud, Julie Di Martino, Bénédicte Salin, Anne Devin, Christophe Cullin, Christelle Marchal
    Disease Models & Mechanisms 2013 6: 206-216; doi: 10.1242/dmm.010108
  • Open Access
    A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions
    Robert Kraft, Allon Kahn, José L. Medina-Franco, Mikayla L. Orlowski, Cayla Baynes, Fabian López-Vallejo, Kobus Barnard, Gerald M. Maggiora, Linda L. Restifo
    Disease Models & Mechanisms 2013 6: 217-235; doi: 10.1242/dmm.008243
  • Open Access
    A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis
    John R. Speakman, Klaas R. Westerterp
    Disease Models & Mechanisms 2013 6: 236-251; doi: 10.1242/dmm.010009
  • Open Access
    Characterising the tumour morphological response to therapeutic intervention: an ex vivo model
    Anne Savage, Elad Katz, Alistair Eberst, Ruth E. Falconer, Alasdair Houston, David J. Harrison, James Bown
    Disease Models & Mechanisms 2013 6: 252-260; doi: 10.1242/dmm.009886

Research Report

  • Open Access
    Serotonin has early, cilia-independent roles in Xenopus left-right patterning
    Laura N. Vandenberg, Joan M. Lemire, Michael Levin
    Disease Models & Mechanisms 2013 6: 261-268; doi: 10.1242/dmm.010256

Resource Article

  • Open Access
    Creation and preliminary characterization of a Tp53 knockout rat
    Aaron McCoy, Cynthia L. Besch-Williford, Craig L. Franklin, Edward J. Weinstein, Xiaoxia Cui
    Disease Models & Mechanisms 2013 6: 269-278; doi: 10.1242/dmm.009704
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Disease Models & Mechanisms: 6 (1)
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  • Open Access

    Modelling epilepsy in the mouse: challenges and solutions

    Grant F. Marshall, Alfredo Gonzalez-Sulser, Catherine M. Abbott
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
  • Open Access

    Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

    Paco López-Cuevas, Luke Deane, Yushi Yang, Chrissy L Hammond, Erika Kague
    PDF
  • Open Access

    Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

    Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
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Monica Justice bids farewell to DMM

In her farewell Editorial, outgoing Editor-in-Chief Monica Justice reminds us of the past half-decade of growth and of DMM's commitment to support the disease modelling community, concluding, “The knowledge and experience I gained during my time as Senior Editor and EiC at DMM is invaluable: working within a not-for-profit community publishing environment is a joy.”


3D imaging of beta cell mass in diabetic mouse models

In their inducible mouse model of diabetes, Roostalu et al. demonstrate how quantitative light-sheet imaging can capture changes in individual islets to help pharmacological research in diabetes.

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Modelling Joubert syndrome patient-derived mutations in C. elegans

In this issue’s Editor’s choice, Karen Lange and colleagues used C. elegans to model and characterise two patient-derived mutations that cause the ciliopathy Joubert syndrome.


Interview – Karen Lange

First author of our current Editor’s choice, Karen Lange takes us behind the scenes of the paper, and shares her thoughts on how the lack of both time and job security will impact her research.

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