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  Open access

November, 2012; 5 (6)

In This Issue

  • Open Access
    In vivo model for modulators of CFTRΔF508 misfolding
    Disease Models & Mechanisms 2012 5: 707
  • Open Access
    Exploring long-term outcomes of galactosemia in flies
    Disease Models & Mechanisms 2012 5: 707
  • Open Access
    Haem-driven IL-1 in acute brain injury
    Disease Models & Mechanisms 2012 5: 707
  • Open Access
    Disease-associated CNVs: zebrafish provide clues
    Disease Models & Mechanisms 2012 5: 707
  • Open Access
    Zebrafish model of neurofibromatosis type 1
    Disease Models & Mechanisms 2012 5: 707
  • Open Access
    New zebrafish model of seizure
    Disease Models & Mechanisms 2012 5: 707

Research Highlights

  • Open Access
    Tissue regeneration in mammals: clues from Acomys mice
    Disease Models & Mechanisms 2012 5: 708
  • Open Access
    CF-related diabetes: new insights from ferrets
    Disease Models & Mechanisms 2012 5: 708
  • Open Access
    Immune system eliminates polyploid cancer cells
    Disease Models & Mechanisms 2012 5: 708
  • Open Access
    Niemann-Pick disease and platelet dysfunction
    Disease Models & Mechanisms 2012 5: 708

Journal Club

  • Open Access
    Finding NECA: zebrafish screen identifies key signalling pathway in β-cell regeneration
    Asha Seth
    Disease Models & Mechanisms 2012 5: 709-710; doi: 10.1242/dmm.010876
  • Open Access
    Lactate-starved neurons in ALS
    Bryan A. Martinez
    Disease Models & Mechanisms 2012 5: 711-712; doi: 10.1242/dmm.010892

A Model For Life

  • Open Access
    Synergy in science: an interview with Neal Copeland and Nancy Jenkins
    Disease Models & Mechanisms 2012 5: 713-717; doi: 10.1242/dmm.010991

Clinical Puzzle

  • Open Access
    Do stroke models model stroke?
    Philipp Mergenthaler, Andreas Meisel
    Disease Models & Mechanisms 2012 5: 718-725; doi: 10.1242/dmm.010033

Primer

  • Open Access
    Zebrafish models flex their muscles to shed light on muscular dystrophies
    Joachim Berger, Peter D. Currie
    Disease Models & Mechanisms 2012 5: 726-732; doi: 10.1242/dmm.010082

Special Article

  • Open Access
    Preclinical research in Rett syndrome: setting the foundation for translational success
    David M. Katz, Joanne E. Berger-Sweeney, James H. Eubanks, Monica J. Justice, Jeffrey L. Neul, Lucas Pozzo-Miller, Mary E. Blue, Diana Christian, Jacqueline N. Crawley, Maurizio Giustetto, Jacky Guy, C. James Howell, Miriam Kron, Sacha B. Nelson, Rodney C. Samaco, Laura R. Schaevitz, Coryse St. Hillaire-Clarke, Juan L. Young, Huda Y. Zoghbi, Laura A. Mamounas
    Disease Models & Mechanisms 2012 5: 733-745; doi: 10.1242/dmm.011007

Perspective

  • Open Access
    Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases
    Jean E. Vance
    Disease Models & Mechanisms 2012 5: 746-755; doi: 10.1242/dmm.010124

Commentaries

  • Open Access
    Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis
    Frederick S. Kaplan, Salin A. Chakkalakal, Eileen M. Shore
    Disease Models & Mechanisms 2012 5: 756-762; doi: 10.1242/dmm.010280
  • Open Access
    Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models
    Jinsong Hu, Els Van Valckenborgh, Eline Menu, Elke De Bruyne, Karin Vanderkerken
    Disease Models & Mechanisms 2012 5: 763-771; doi: 10.1242/dmm.008961

Research Articles

  • Open Access
    Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures
    Sarah Baxendale, Celia J. Holdsworth, Paola L. Meza Santoscoy, Michael R. M. Harrison, James Fox, Caroline A. Parkin, Philip W. Ingham, Vincent T. Cunliffe
    Disease Models & Mechanisms 2012 5: 773-784; doi: 10.1242/dmm.010090
  • Open Access
    Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs
    Gang-Hui Lee, Shian-Ying Sung, Wen-Ni Chang, Tseng-Ting Kao, Hung-Chi Du, Tsun-Hsien Hsiao, Martin K. Safo, Tzu-Fun Fu
    Disease Models & Mechanisms 2012 5: 785-795; doi: 10.1242/dmm.009449
  • Open Access
    Mediators of a long-term movement abnormality in a Drosophila melanogaster model of classic galactosemia
    Emily L. Ryan, Brian DuBoff, Mel B. Feany, Judith L. Fridovich-Keil
    Disease Models & Mechanisms 2012 5: 796-803; doi: 10.1242/dmm.009050
  • Open Access
    Characterization of a canine model of glycogen storage disease type IIIa
    Haiqing Yi, Beth L. Thurberg, Sarah Curtis, Stephanie Austin, John Fyfe, Dwight D. Koeberl, Priya S. Kishnani, Baodong Sun
    Disease Models & Mechanisms 2012 5: 804-811; doi: 10.1242/dmm.009712
  • Open Access
    Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a newly identified cause of congenital ear malformation
    Lely A. Quina, Takashi Kuramoto, Daniela V. Luquetti, Timothy C. Cox, Tadao Serikawa, Eric E. Turner
    Disease Models & Mechanisms 2012 5: 812-822; doi: 10.1242/dmm.009910
  • Open Access
    Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology
    Andrew D. Greenhalgh, David Brough, Emily M. Robinson, Sylvie Girard, Nancy J. Rothwell, Stuart M. Allan
    Disease Models & Mechanisms 2012 5: 823-833; doi: 10.1242/dmm.008557
  • Open Access
    Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes
    Alicia Blaker-Lee, Sunny Gupta, Jasmine M. McCammon, Gianluca De Rienzo, Hazel Sive
    Disease Models & Mechanisms 2012 5: 834-851; doi: 10.1242/dmm.009944
  • Open Access
    Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models
    James J. Dowling, Romain Joubert, Sean E. Low, Ashley N. Durban, Nadia Messaddeq, Xingli Li, Ashley N. Dulin-Smith, Andrew D. Snyder, Morgan L. Marshall, Jordan T. Marshall, Alan H. Beggs, Anna Buj-Bello, Christopher R. Pierson
    Disease Models & Mechanisms 2012 5: 852-859; doi: 10.1242/dmm.009746
  • Open Access
    Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich’s ataxia
    Alain Martelli, Lisa S. Friedman, Laurence Reutenauer, Nadia Messaddeq, Susan L. Perlman, David R. Lynch, Kathrin Fedosov, Jörg B. Schulz, Massimo Pandolfo, Hélène Puccio
    Disease Models & Mechanisms 2012 5: 860-869; doi: 10.1242/dmm.009829
  • Open Access
    Neonatal diethylstilbestrol exposure alters the metabolic profile of uterine epithelial cells
    Yan Yin, Congxing Lin, G. Michael Veith, Hong Chen, Maulik Dhandha, Liang Ma
    Disease Models & Mechanisms 2012 5: 870-880; doi: 10.1242/dmm.009076
  • Open Access
    Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development
    Jimann Shin, Arun Padmanabhan, Eric D. de Groh, Jeong-Soo Lee, Sam Haidar, Suzanne Dahlberg, Feng Guo, Shuning He, Marc A. Wolman, Michael Granato, Nathan D. Lawson, Scot A. Wolfe, Seok-Hyung Kim, Lilianna Solnica-Krezel, John P. Kanki, Keith L. Ligon, Jonathan A. Epstein, A. Thomas Look
    Disease Models & Mechanisms 2012 5: 881-894; doi: 10.1242/dmm.009779
  • Open Access
    Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice
    Sarah Giese, Hamid Hossain, Melanie Markmann, Trinad Chakraborty, Svetlin Tchatalbachev, Florian Guillou, Martin Bergmann, Klaus Failing, Karola Weider, Ralph Brehm
    Disease Models & Mechanisms 2012 5: 895-913; doi: 10.1242/dmm.008649
  • Open Access
    Initiation of prostate cancer in mice by Tp53R270H: evidence for an alternative molecular progression
    Ruth L. Vinall, Jane Q. Chen, Neil E. Hubbard, Shola S. Sulaimon, Michael M. Shen, Ralph W. DeVere White, Alexander D. Borowsky
    Disease Models & Mechanisms 2012 5: 914-920; doi: 10.1242/dmm.008995
  • Open Access
    Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development
    Fadi A. Issa, Allan F. Mock, Alvaro Sagasti, Diane M. Papazian
    Disease Models & Mechanisms 2012 5: 921-929; doi: 10.1242/dmm.010157

Research Reports

  • Open Access
    The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3
    Liping He, Jennifer Skirkanich, Lorenza Moronetti, Rosemary Lewis, Todd Lamitina
    Disease Models & Mechanisms 2012 5: 930-939; doi: 10.1242/dmm.008987
  • Open Access
    Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems
    Scott A. Nelson, Zhouyu Li, Ian P. Newton, David Fraser, Rachel E. Milne, David M. A. Martin, David Schiffmann, Xuesong Yang, Dirk Dormann, Cornelis J. Weijer, Paul L. Appleton, Inke S. Näthke
    Disease Models & Mechanisms 2012 5: 940-947; doi: 10.1242/dmm.008607
  • Open Access
    Reduced bone morphogenetic protein receptor type 1A signaling in neural-crest-derived cells causes facial dysmorphism
    Hiromitsu Saito, Ken-ichi Yamamura, Noboru Suzuki
    Disease Models & Mechanisms 2012 5: 948-955; doi: 10.1242/dmm.009274

Resource Article

  • Open Access
    Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice
    Palle Serup, Carsten Gustavsen, Tino Klein, Leah A. Potter, Robert Lin, Nandita Mullapudi, Ewa Wandzioch, Angela Hines, Ashley Davis, Christine Bruun, Nina Engberg, Dorthe R. Petersen, Janny M. L. Peterslund, Raymond J. MacDonald, Anne Grapin-Botton, Mark A. Magnuson, Kenneth S. Zaret
    Disease Models & Mechanisms 2012 5: 956-966; doi: 10.1242/dmm.009696
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Disease Models & Mechanisms: 5 (6)
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  • Research Highlights
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  • Open Access

    Metabolomics and lipidomics in C. elegans using a single sample preparation

    Marte Molenaars, Bauke V. Schomakers, Hyung L. Elfrink, Arwen W. Gao, Martin A. T. Vervaart, Mia L. Pras-Raves, Angela C. Luyf, Reuben L. Smith, Mark G. Sterken, Jan E. Kammenga, Antoine H. C. van Kampen, Georges E. Janssens, Frédéric M. Vaz, Michel van Weeghel, Riekelt H. Houtkooper
    PDF
  • Open Access

    High dimensional immunotyping of tumors grown in obese and non-obese mice

    Cara E. Wogsland, Hilde E. Lien, Line Pedersen, Pahul Hanjra, Sturla M. Grondal, Rolf A. Brekken, James B. Lorens, Nils Halberg
    PDF
  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
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