Mutations in the CDKN1C gene are associated with the childhood developmental disorder Beckwith-Wiedemann syndrome (BWS), whose main symptom is overgrowth of body and organ size. Cdkn1c-knockout mice do not show overgrowth at birth, casting doubt on the validity of mice as an appropriate BWS model. Now, Tunster et al. show that CDKN1C-deficient mouse foetuses do overgrow, but the effect is lost shortly before birth if the knockout foetuses are part of a large litter. This might have important implications for BWS underdiagnosis in non-singleton pregnancies in humans. Page 814
- Written by editorial staff. © 2011. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
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