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  You have access

  Open access

November, 2011; 4 (6)

In This Issue

  • Open Access
    Linked defects in secretory pathways and skeletal morphogenesis
    Disease Models & Mechanisms 2011 4: 709
  • Open Access
    Validating mouse model of Beckwith-Wiedemann syndrome
    Disease Models & Mechanisms 2011 4: 709
  • Open Access
    Feeding frenzy: Drosophila model of type 2 diabetes
    Disease Models & Mechanisms 2011 4: 709
  • Open Access
    Zebrafish model for IBD
    Disease Models & Mechanisms 2011 4: 709
  • Open Access
    Modelling liver cancer in transgenic zebrafish
    Disease Models & Mechanisms 2011 4: 709
  • Open Access
    Yeast-based screen for inhibitors of Aβ oligomerisation
    Disease Models & Mechanisms 2011 4: 709
  • Open Access
    Usher syndrome: a developmental disease of vision?
    Disease Models & Mechanisms 2011 4: 709
  • Open Access
    Investigating heritable skin disorders in zebrafish
    Disease Models & Mechanisms 2011 4: 709

Research Highlights

  • Open Access
    Triglyceride turnover in metabolic disease
    Disease Models & Mechanisms 2011 4: 710
  • Open Access
    Cardiac hypertrophy: new role for endonuclease G
    Disease Models & Mechanisms 2011 4: 710
  • Open Access
    CNTNAP2: exploring association with autism phenotypes in mice
    Disease Models & Mechanisms 2011 4: 710
  • Open Access
    Neuropathological potential of FUS and TDP-43 in flies
    Disease Models & Mechanisms 2011 4: 710

Journal Club

  • Open Access
    A NOD to zebrafish models of inflammatory bowel disease pathogenesis
    Irving C. Allen
    Disease Models & Mechanisms 2011 4: 711-712; doi: 10.1242/dmm.008805
  • Open Access
    Pathological looping in the synucleinopathies: investigating the link between Parkinson’s disease and Gaucher disease
    Kerri J. Kinghorn
    Disease Models & Mechanisms 2011 4: 713-715; doi: 10.1242/dmm.008615

A Model For Life

  • Open Access
    Mouse genetics for studying mechanisms of deafness and more: an interview with Karen Steel
    Disease Models & Mechanisms 2011 4: 716-718; doi: 10.1242/dmm.008813

Book Review

  • Open Access
    Ending it all in style
    Sally Kornbluth
    Disease Models & Mechanisms 2011 4 719-720; doi: 10.1242/dmm.008664

Clinical Puzzle

  • Open Access
    Regulating complement in the kidney: insights from CFHR5 nephropathy
    Daniel P. Gale, Matthew C. Pickering
    Disease Models & Mechanisms 2011 4: 721-726; doi: 10.1242/dmm.008052

At A Glance

  • Open Access
    Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
    Nihed Draoui, Olivier Feron
    Disease Models & Mechanisms 2011 4: 727-732; doi: 10.1242/dmm.007724

Special Article

  • Open Access
    Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity
    John R. Speakman, David A. Levitsky, David B. Allison, Molly S. Bray, John M. de Castro, Deborah J. Clegg, John C. Clapham, Abdul G. Dulloo, Laurence Gruer, Sally Haw, Johannes Hebebrand, Marion M. Hetherington, Susanne Higgs, Susan A. Jebb, Ruth J. F. Loos, Simon Luckman, Amy Luke, Vidya Mohammed-Ali, Stephen O’Rahilly, Mark Pereira, Louis Perusse, Tom N. Robinson, Barbara Rolls, Michael E. Symonds, Margriet S. Westerterp-Plantenga
    Disease Models & Mechanisms 2011 4: 733-745; doi: 10.1242/dmm.008698

Commentary

  • Open Access
    Animal models for Gaucher disease research
    Tamar Farfel-Becker, Einat B. Vitner, Anthony H. Futerman
    Disease Models & Mechanisms 2011 4: 746-752; doi: 10.1242/dmm.008185

Perspective

  • Open Access
    Modeling tumor invasion and metastasis in Drosophila
    Wayne O. Miles, Nicholas J. Dyson, James A. Walker
    Disease Models & Mechanisms 2011 4: 753-761; doi: 10.1242/dmm.006908

Podcast

  • You have accessSubscription required
    November 2011 DMM Podcast: an interview with Karen Steel
    Disease Models & Mechanisms 2011 4: e4 doi: 10.1242/dmm.008920

Research Articles

  • Open Access
    The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis
    David B. Melville, Mercedes Montero-Balaguer, Daniel S. Levic, Kevin Bradley, Jeffrey R. Smith, Antonis K. Hatzopoulos, Ela W. Knapik
    Disease Models & Mechanisms 2011 4: 763-776; doi: 10.1242/dmm.007625
  • Open Access
    Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis
    Qiaoli Li, Michael Frank, Masashi Akiyama, Hiroshi Shimizu, Shiu-Ying Ho, Christine Thisse, Bernard Thisse, Eli Sprecher, Jouni Uitto
    Disease Models & Mechanisms 2011 4: 777-785; doi: 10.1242/dmm.007146
  • Open Access
    Harmonin (Ush1c) is required in zebrafish Müller glial cells for photoreceptor synaptic development and function
    Jennifer B. Phillips, Bernardo Blanco-Sanchez, Jennifer J. Lentz, Alexandra Tallafuss, Kornnika Khanobdee, Srirangan Sampath, Zachary G. Jacobs, Philip F. Han, Monalisa Mishra, Tom A. Titus, David S. Williams, Bronya J. Keats, Philip Washbourne, Monte Westerfield
    Disease Models & Mechanisms 2011 4: 786-800; doi: 10.1242/dmm.006429
  • Open Access
    A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish
    Anh Tuan Nguyen, Alexander Emelyanov, Chor Hui Vivien Koh, Jan M. Spitsbergen, Siew Hong Lam, Sinnakaruppan Mathavan, Serguei Parinov, Zhiyuan Gong
    Disease Models & Mechanisms 2011 4: 801-813; doi: 10.1242/dmm.007831
  • Open Access
    Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome
    Simon J. Tunster, Mathew Van de Pette, Rosalind M. John
    Disease Models & Mechanisms 2011 4: 814-821; doi: 10.1242/dmm.007328
  • Open Access
    Development and validation of a yeast high-throughput screen for inhibitors of Aβ42 oligomerization
    Sei-Kyoung Park, Scott D. Pegan, Andrew D. Mesecar, Lisa M. Jungbauer, Mary Jo LaDu, Susan W. Liebman
    Disease Models & Mechanisms 2011 4: 822-831; doi: 10.1242/dmm.007963

Research Reports

  • Open Access
    The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish
    Stefan H. Oehlers, Maria Vega Flores, Chris J. Hall, Simon Swift, Kathryn E. Crosier, Philip S. Crosier
    Disease Models & Mechanisms 2011 4: 832-841; doi: 10.1242/dmm.006122
  • Open Access
    A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila
    Laura Palanker Musselman, Jill L. Fink, Kirk Narzinski, Prasanna Venkatesh Ramachandran, Sumitha Sukumar Hathiramani, Ross L. Cagan, Thomas J. Baranski
    Disease Models & Mechanisms 2011 4: 842-849; doi: 10.1242/dmm.007948
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Disease Models & Mechanisms: 4 (6)
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  • In This Issue
  • Research Highlights
  • Journal Club
  • A Model For Life
  • Book Review
  • Clinical Puzzle
  • At A Glance
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  • Commentary
  • Perspective
  • Podcast
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  • Open Access

    Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency

    Alessia Niceforo, Chiara Marioli, Fiorella Colasuonno, Stefania Petrini, Keith Massey, Marco Tartaglia, Enrico Bertini, Sandra Moreno, Claudia Compagnucci
    PDF
  • Open Access

    Genetic background modifies vulnerability to glaucoma related phenotypes in Lmx1b mutant mice

    N. G. Tolman, R. Balasubramanian, D. G. Macalinao, A. L. Kearney, K. H. MacNicoll, C. L. Montgomery, W. N. de Vries, I. J. Jackson, S. H. Cross, K. Kizhatil, K. S. Nair, S. W. M. John
    PDF
  • Open Access

    Neural crest-specific deletion of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction, and disordered breathing modelling Obstructive Sleep Apnea

    Pranidhi Baddam, Vivian Biancardi, Daniela M. Roth, Farah Eaton, Claudine Thereza-Bussolaro, Rupasri Mandal, David S. Wishart, Amy Barr, Joanna MacLean, Carlos Flores-Mir, Silvia Pagliardini, Daniel Graf
    PDF
  • Open Access

    Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

    F. W. Riemslagh, E. C. van der Toorn, R. F. M. Verhagen, A. Maas, L. W. J. Bosman, R. K. Hukema, R. Willemsen
    PDF
  • Open Access

    A muscle growth promoting treatment based on the attenuation of activin/myostatin signalling in young mice results in long-term testicular abnormalities

    Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
    PDF
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Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart

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C. elegans as a disease model

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Call for papers – The RAS Pathway: Diseases, Therapeutics and Beyond

Our upcoming special issue is now welcoming submissions until 1 April 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on the targeting the RAS pathway. Find out more about the issue and how to submit your manuscript.


Interview – Kim Landry-Truchon and Nicolas Houde

In an interview, first authors Kim Landry-Truchon and Nicolas Houde discuss their mouse model of the early stages of pleuropulmonary blastoma, reflecting on the implications of their work and the future of their field.

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