In This Issue
Research Highlights
Journal Club
A Model For Life
Book Review
Commentary
Research Articles
This issue
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First person – Zhaoyang, Omkara, Christine and Yong
Catch up with our first authors in the latest interviews. Zhaoyang Liu, Omkara Lakshmi Veeranki, Christine Lehner and Yong Chen discuss the implications of their research, life as an early-career researcher and their next steps.
A new resource article by Dipen Maru's group describes a patient-derived orthotopic xenograft model of gastroesphageal cancer that maintains the morphological and molecular characteristics of the source tumour.
There are still funded places available for early-career researchers at July’s Workshop on inflammaging and regeneration! The deadline for applications is 14 February. We’re also interested to hear your ideas for Workshops – find out more about how we can provide support.
The first preLight of 2020 and the first time we’ve highlighted a medRxiv preprint! Zhang-He Goh discusses a new preprint by Witte et al. assessing the correlation between ovarian cancer patient-derived organoids and patients’ clinical response to chemotherapeutics.
Cover article – Regulation of terminal hypertrophic chondrocyte differentiation in Prmt5 mutant mice modeling infantile idiopathic scoliosis
On the cover, research by Liu et al. demonstrates that the loss of Prmt5 osteochondral progenitors impairs terminal hypertrophic chondrocyte differentiation, leading to defects in endochondral bone formation and models infantile idiopathic scoliosis in mouse.