Cover image
Cover: A 17.5-day-old chimeric mouse embryo that was obtained by microinjecting three different mouse embryonic stem (ES) cell lines, which individually express cyan, green or red fluorescent proteins under control of the ROSA26 locus, into 3-day-old blastocysts obtained from the natural matings of C57Bl/6 mice. The cyan, green and red fluorescence in this high-degree polychromatic embryo reflect the specific developmental contributions of the injected ES cells. See article by Chen et al. on page 537.
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DMM and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
Interviews – Sneh, Mami and Myumi
Continuing our ongoing support to early-career researchers, Sneh Harsh, Mami Uemura and Myumi Higashi share the story behind their latest DMM research, what this means for the field and where their science journey is heading to next.
Membrane trafficking in health and disease
Martin Lowe and his team summarise the major intracellular membrane trafficking pathways and associated molecular machineries, and describe how defects in these give rise to disease in humans, in an At a Glance article and poster.
Editor's choice - Familial hypercholesterolemia class II LDL receptor response to statin treatment
Nolan L Boyd and colleagues used an iPSC-based model of familiar hypercholeserolemia to investigate how mutant LDL receptors respond to statins.