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  You have access

  Open access

January 1, 2011; 4 (1)

In This Issue

  • Open Access
    Venous malformations: TIEing genotype to phenotype in zebrafish
    Disease Models & Mechanisms 2011 4: 1
  • Open Access
    Partial inhibition of Akt activity might be enough to beat cancer
    Disease Models & Mechanisms 2011 4: 1
  • Open Access
    Insight into metastasis through studying Drosophila haemocyte migration
    Disease Models & Mechanisms 2011 4: 1
  • Open Access
    PEX13-knockout mice model Zellweger syndrome
    Disease Models & Mechanisms 2011 4: 1
  • Open Access
    Shock therapy: modulating stem cells
    Disease Models & Mechanisms 2011 4: 1
  • Open Access
    pH-dependent regulation of Batten disease protein
    Disease Models & Mechanisms 2011 4: 1
  • Open Access
    Announcing a xenograft model of E. coli O157:H7
    Disease Models & Mechanisms 2011 4: 1
  • Open Access
    Mapping mutations in a mouse model of Meckel-Gruber syndrome
    Disease Models & Mechanisms 2011 4: 1

Research Highlights

  • Open Access
    In vivo screen for suppressors of long QT syndrome
    Disease Models & Mechanisms 2011 4: 2
  • Open Access
    Muscle senescence regulates systemic tissue ageing in flies
    Disease Models & Mechanisms 2011 4: 2
  • Open Access
    Invasive human epithelial neoplasia in 3D
    Disease Models & Mechanisms 2011 4: 2
  • Open Access
    EphB2: potential therapeutic target for Alzheimer’s disease
    Disease Models & Mechanisms 2011 4: 2

Editorial

  • Open Access
    Changes we can believe in
    Vivian Siegel
    Disease Models & Mechanisms 2011 4: 3-4; doi: 10.1242/dmm.007294

Journal Club

  • Open Access
    Vascular homeostasis: insights from a fibrotic mouse
    Stephen P. Santoro, Nancy L. Maas
    Disease Models & Mechanisms 2011 4: 5-6; doi: 10.1242/dmm.006726
  • Open Access
    Understanding gene-environment interactions in a mouse model of Crohn’s disease
    Carrie A. Duckworth
    Disease Models & Mechanisms 2011 4: 7-8; doi: 10.1242/dmm.007120

A Model for Life

  • Open Access
    At the leading edge of cancer research: an interview with Joan Brugge
    Disease Models & Mechanisms 2011 4: 9-11; doi: 10.1242/dmm.007229

Primer

  • Open Access
    The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration
    Luca Gentile, Francesc Cebrià, Kerstin Bartscherer
    Disease Models & Mechanisms 2011 4: 12-19; doi: 10.1242/dmm.006692

Perspectives

  • Open Access
    Drosophila melanogaster as a model for human intestinal infection and pathology
    Yiorgos Apidianakis, Laurence G. Rahme
    Disease Models & Mechanisms 2011 4: 21-30; doi: 10.1242/dmm.003970
  • Open Access
    Degeneration and regeneration of the intervertebral disc: lessons from development
    Lachlan J. Smith, Nandan L. Nerurkar, Kyung-Suk Choi, Brian D. Harfe, Dawn M. Elliott
    Disease Models & Mechanisms 2011 4: 31-41; doi: 10.1242/dmm.006403

Research Articles

  • Open Access
    Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome
    Cheng Cui, Bishwanath Chatterjee, Deanne Francis, Qing Yu, Jovenal T. SanAgustin, Richard Francis, Terry Tansey, Charisse Henry, Baolin Wang, Bethan Lemley, Gregory J. Pazour, Cecilia W. Lo
    Disease Models & Mechanisms 2011 4: 43-56; doi: 10.1242/dmm.006262
  • Open Access
    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2011 4: 54 doi: 10.1242/dmm.006890
  • Open Access
    Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity
    Evisa Gjini, Liesbeth H. Hekking, Axel Küchler, Pipsa Saharinen, Erno Wienholds, Jan-Andries Post, Kari Alitalo, Stefan Schulte-Merker
    Disease Models & Mechanisms 2011 4: 57-66; doi: 10.1242/dmm.005033
  • Open Access
    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2011 4: 65 doi: 10.1242/dmm.006916
  • Open Access
    Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway
    Douglas Blackiston, Dany S. Adams, Joan M. Lemire, Maria Lobikin, Michael Levin
    Disease Models & Mechanisms 2011 4: 67-85; doi: 10.1242/dmm.005561
  • Open Access
    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2011 4: 80 doi: 10.1242/dmm.006650
  • Open Access
    Enterohemorrhagic Escherichia coli induce attaching and effacing lesions and hemorrhagic colitis in human and bovine intestinal xenograft models
    Lilach Golan, Erez Gonen, Simcha Yagel, Ilan Rosenshine, Nahum Y. Shpigel
    Disease Models & Mechanisms 2011 4: 86-94; doi: 10.1242/dmm.005777
  • Open Access
    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2011 4: 93 doi: 10.1242/dmm.006577
  • Open Access
    How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance
    Stephan Wullschleger, Kei Sakamoto, Lana Johnstone, Suzanne Duce, Stewart Fleming, Dario R. Alessi
    Disease Models & Mechanisms 2011 4: 95-103; doi: 10.1242/dmm.005603
  • Open Access
    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2011 4: 102 doi: 10.1242/dmm.006544
  • Open Access
    PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress
    C. Catharina Müller, Tam H. Nguyen, Barbara Ahlemeyer, Mallika Meshram, Nishreen Santrampurwala, Siyu Cao, Peter Sharp, Pamela B. Fietz, Eveline Baumgart-Vogt, Denis I. Crane
    Disease Models & Mechanisms 2011 4: 104-119; doi: 10.1242/dmm.004622
  • Open Access
    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2011 4: 117 doi: 10.1242/dmm.006536

Research Reports

  • Open Access
    pH-dependent localization of Btn1p in the yeast model for Batten disease
    Devin M. Wolfe, Sergio Padilla-Lopez, Seasson Phillips Vitiello, David A. Pearce
    Disease Models & Mechanisms 2011 4: 120-125; doi: 10.1242/dmm.006114
  • Open Access
    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2011 4: 124 doi: 10.1242/dmm.006601
  • Open Access
    Ena drives invasive macrophage migration in Drosophila embryos
    Philippa K. Tucker, Iwan R. Evans, Will Wood
    Disease Models & Mechanisms 2011 4: 126-134; doi: 10.1242/dmm.005694
  • Open Access
    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2011 4: 132 doi: 10.1242/dmm.006528
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Disease Models & Mechanisms: 4 (1)
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  • Open Access

    Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes

    Phillipe D. O'Brien, Kai Guo, Stephanie A. Eid, Amy E. Rumora, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson, Junguk Hur, Eva L. Feldman
    PDF
  • Open Access

    A comparison of the bone and growth phenotype of mdx, mdx:cmah−/− and mdx:utrn+/− murine models with the C57BL10 wildtype mouse

    C. L. Wood, K. J. Suchaki, R. van 't Hof, W. P. Cawthorn, S. Dillon, V. Straub, S. C. Wong, S. F. Ahmed, C. Farquharson
    PDF
  • Open Access

    Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

    Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger
    PDF
  • Open Access

    A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries

    Omkara Lakshmi Veeranki, Zhimin Tong, Alicia Mejia, Anuj Verma, Riham Katkhuda, Roland Bassett, Tae-Beom Kim, Jing Wang, Wenhua Lang, Barbara Mino, Luisa Solis, Charles Kingsley, William Norton, Ramesh Tailor, Ji Yuan Wu, Sunil Krishnan, Steven H. Lin, Mariela Blum, Wayne Hofstetter, Jaffer Ajani, Scott Kopetz, Dipen Maru
    PDF
  • Open Access

    A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

    Alberto Rissone, Erin Jimenez, Kevin Bishop, Blake Carrington, Claire Slevin, Stephen M. Wincovitch, Raman Sood, Fabio Candotti, Shawn M. Burgess
    PDF
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Review – CRISPR/Cas9-mediated genome editing in nonhuman primates

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Travelling Fellowship – New imaging approach unveils a bigger picture

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