Disease Models & Mechanisms: 3 (7-8)

July, 2010; 3 (7-8)

In This Issue

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A zebrafish model for liver regeneration
Disease Models & Mechanisms 2010 3: 397
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Polycystin toxicity in C. elegans
Disease Models & Mechanisms 2010 3: 397
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Fatty liver disease in ricefish
Disease Models & Mechanisms 2010 3: 397
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Mouse susceptibility to depression
Disease Models & Mechanisms 2010 3: 397
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Functional conservation of FXR genes
Disease Models & Mechanisms 2010 3: 397
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Fracture repair in Ccr2 knockout mice
Disease Models & Mechanisms 2010 3: 397
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Tissue regeneration
Disease Models & Mechanisms 2010 3: 397

Research Highlights

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Metabolism and aging: ER stress prolongs life
Disease Models & Mechanisms 2010 3: 398
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Neurodegeneration: Alzheimer’s disease
Disease Models & Mechanisms 2010 3: 398
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Mental health: spadin, a fast-acting antidepressant
Disease Models & Mechanisms 2010 3: 398
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Angiogenesis: coupling ephrin-B2 and VEGF
Disease Models & Mechanisms 2010 3: 398

Journal Club

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Preventing Parkinson’s pathology
Morgan E. DeSantis, Devin Dersh

Disease Models & Mechanisms 2010 3: 399-400; doi: 10.1242/dmm.005678

Community News

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Pharmaceutical training for clinicians
Disease Models & Mechanisms 2010 3: 401 doi: 10.1242/dmm.006049
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DMM Travelling Fellowships
Disease Models & Mechanisms 2010 3: 401-402; doi: 10.1242/dmm.006056
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Professor Stephen O’Rahilly wins the 2010 InBev-Baillet Latour Prize
Disease Models & Mechanisms 2010 3: 402 doi: 10.1242/dmm.006080

A Model For Life

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Engineering new medicine: an interview with James Collins
Kristin H. Kain

Disease Models & Mechanisms 2010 3: 403-406; doi: 10.1242/dmm.006023

Clinical Puzzle

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Preventing preterm birth: the past limitations and new potential of animal models
Christine K. Ratajczak, Justin C. Fay, Louis J. Muglia

Disease Models & Mechanisms 2010 3: 407-414; doi: 10.1242/dmm.001701

Primer

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The role of insulin/IGF-like signaling in C. elegans longevity and aging
Rachel Kaletsky, Coleen T. Murphy

Disease Models & Mechanisms 2010 3: 415-419; doi: 10.1242/dmm.001040

Commentaries

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Potential and pitfalls of stem cell therapy in old age
David Piccin, Cindi M. Morshead

Disease Models & Mechanisms 2010 3: 421-425; doi: 10.1242/dmm.003137
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Sweetness and light: perspectives for rodent models of type 1 diabetes
Philip R. Avner

Disease Models & Mechanisms 2010 3: 426-429; doi: 10.1242/dmm.004705

Research Articles

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Medaka as a model for human nonalcoholic steatohepatitis
Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida

Disease Models & Mechanisms 2010 3: 431-440; doi: 10.1242/dmm.002311
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2010 3: 439 doi: 10.1242/dmm.005355
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A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5
Renee M. Miller, Douglas S. Portman

Disease Models & Mechanisms 2010 3: 441-450; doi: 10.1242/dmm.002816
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2010 3: 449 doi: 10.1242/dmm.005348
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Multiple roles for CCR2 during fracture healing
Zhiqing Xing, Chuanyong Lu, Diane Hu, Yan-yiu Yu, Xiaodong Wang, Celine Colnot, Mary Nakamura, Yalei Wu, Theodore Miclau, Ralph S. Marcucio

Disease Models & Mechanisms 2010 3: 451-458; doi: 10.1242/dmm.003186
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2010 3: 457 doi: 10.1242/dmm.005512
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Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice
Alessandro Bartolomucci, Valeria Carola, Tiziana Pascucci, Stefano Puglisi-Allegra, Simona Cabib, Klaus-Peter Lesch, Stefano Parmigiani, Paola Palanza, Cornelius Gross

Disease Models & Mechanisms 2010 3: 459-470; doi: 10.1242/dmm.004614
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2010 3: 468 doi: 10.1242/dmm.005405
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Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P
R. Lane Coffee, Jr, Charles R. Tessier, Elvin A. Woodruff III, Kendal Broadie

Disease Models & Mechanisms 2010 3: 471-485; doi: 10.1242/dmm.004598
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2010 3: 483 doi: 10.1242/dmm.005363
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The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model
Silvia Curado, Elke A. Ober, Susan Walsh, Paulina Cortes-Hernandez, Heather Verkade, Carla M. Koehler, Didier Y. R. Stainier

Disease Models & Mechanisms 2010 3: 486-495; doi: 10.1242/dmm.004390
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2010 3: 493 doi: 10.1242/dmm.005637

Research Reports

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Ras controls melanocyte expansion during zebrafish fin stripe regeneration
Yoonsung Lee, Gregory Nachtrab, Pai W. Klinsawat, Danyal Hami, Kenneth D. Poss

Disease Models & Mechanisms 2010 3: 496-503; doi: 10.1242/dmm.004515
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2010 3: 502 doi: 10.1242/dmm.005843

This issue

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Open Access

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

Katie Lloyd, Stamatia Papoutsopoulou, Emily Smith, Philip Stegmaier, Francois Bergey, Lorna Morris, Madeleine Kittner, Hazel England, Dave Spiller, Mike H. R. White, Carrie A. Duckworth, Barry J. Campbell, Vladimir Poroikov, Vitor A. P. Martins dos Santos, Alexander Kel, Werner Muller, D. Mark Pritchard, Chris Probert, Michael D. Burkitt, the SysmedIBD consortium

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Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of Atrip-Seckel syndrome

Gabriel E. Matos-Rodrigues, Pedro B. Tan, Maurício Rocha-Martins, Clara F. Charlier, Anielle L. Gomes, Felipe Cabral-Miranda, Paulius Grigaravicius, Thomas G. Hofmann, Pierre-Olivier Frappart, Rodrigo A. P. Martins

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Open Access

Teleological Role of L-2-Hydroxyglutarate Dehydrogenase in the Kidney

Garrett Brinkley, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, Jason M. Tennessen, Juan Liu, Jason W. Locasale, Tao Guo, Shi Wei, Jennifer Gordetsky, Teresa L. Johnson-Pais, Devin Absher, Dinesh Rakheja, Anil K. Challa, Sunil Sudarshan

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Open Access

An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy

Pingtao Tang, Jharna R. Das, Jinliang Li, Jing Yu, Patricio E. Ray

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Open Access

Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

Leonie Drews, Marcel Zimmermann, Philipp Westhoff, Dominik Brilhaus, Rebecca E. Poss, Laura Bergmann, Constanze Wiek, Peter Brenneisen, Roland P. Piekorz, Tabea Mettler-Altmann, Andreas P. M. Weber, Andreas S. Reichert

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Other journals from The Company of Biologists

DMM and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.

Alessandro Bailetti is awarded the DMM Outstanding Paper Prize 2019

The annual prize is awarded to the first author of the paper that is judged by the journal’s editors to be the most outstanding contribution to the journal that year. Alessandro Bailetti's winning paper presents results that indicate a possible connection between E(Pc) and the Tip60 complex, and leukemia. Find out more about Alessandro and read the winning paper.

Find DMM online

We may not be meeting you in person this year, but we’re always here to chat about DMM and The Company of Biologists. Join the conversation over on Twitter, email us or catch Scientific Editor Julija Hmeljak at these upcoming virtual meetings:

MRC Human Genetics Unit (Virtual) Symposium: Aberrant Cell State Transitions in Human Disease
23-24 September

Genomic Imprinting – from Biology to Disease
28 September – 1 October

ZDMS Virtual webinar series
Throughout September – December

Interview - Mohd. Salman

First author Mohd. Salman studies traumatic brain injury. In an interview, he takes us through his latest research in DMM, explaining the potential implications of the findings, and discussing Wistar rats as a model system and life as a early-career researcher.

Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond

DMM invites you to submit original research for a special issue focused on targeting the RAS pathway. The submission deadline is 1 March 2021. Find out more and showcase your breakthrough research in this special collection.

It’s a time of turmoil for young scientists

“My students are my priority – they are on the brink of their careers.”

Dr Jodie Rummer (ARC Centre of Excellence for Coral Reef Studies at James Cook University) talks about the importance of her role as a supervisor in supporting graduate students and post docs financially, intellectually and emotionally during this period of uncertainty.

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