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  Open access

July, 2010; 3 (7-8)

In This Issue

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    A zebrafish model for liver regeneration
    Disease Models & Mechanisms 2010 3: 397
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    Polycystin toxicity in C. elegans
    Disease Models & Mechanisms 2010 3: 397
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    Fatty liver disease in ricefish
    Disease Models & Mechanisms 2010 3: 397
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    Mouse susceptibility to depression
    Disease Models & Mechanisms 2010 3: 397
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    Functional conservation of FXR genes
    Disease Models & Mechanisms 2010 3: 397
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    Fracture repair in Ccr2 knockout mice
    Disease Models & Mechanisms 2010 3: 397
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    Tissue regeneration
    Disease Models & Mechanisms 2010 3: 397

Research Highlights

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    Metabolism and aging: ER stress prolongs life
    Disease Models & Mechanisms 2010 3: 398
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    Neurodegeneration: Alzheimer’s disease
    Disease Models & Mechanisms 2010 3: 398
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    Mental health: spadin, a fast-acting antidepressant
    Disease Models & Mechanisms 2010 3: 398
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    Angiogenesis: coupling ephrin-B2 and VEGF
    Disease Models & Mechanisms 2010 3: 398

Journal Club

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    Preventing Parkinson’s pathology
    Morgan E. DeSantis, Devin Dersh
    Disease Models & Mechanisms 2010 3: 399-400; doi: 10.1242/dmm.005678

Community News

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    Pharmaceutical training for clinicians
    Disease Models & Mechanisms 2010 3: 401 doi: 10.1242/dmm.006049
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    DMM Travelling Fellowships
    Disease Models & Mechanisms 2010 3: 401-402; doi: 10.1242/dmm.006056
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    Professor Stephen O’Rahilly wins the 2010 InBev-Baillet Latour Prize
    Disease Models & Mechanisms 2010 3: 402 doi: 10.1242/dmm.006080

A Model For Life

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    Engineering new medicine: an interview with James Collins
    Kristin H. Kain
    Disease Models & Mechanisms 2010 3: 403-406; doi: 10.1242/dmm.006023

Clinical Puzzle

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    Preventing preterm birth: the past limitations and new potential of animal models
    Christine K. Ratajczak, Justin C. Fay, Louis J. Muglia
    Disease Models & Mechanisms 2010 3: 407-414; doi: 10.1242/dmm.001701

Primer

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    The role of insulin/IGF-like signaling in C. elegans longevity and aging
    Rachel Kaletsky, Coleen T. Murphy
    Disease Models & Mechanisms 2010 3: 415-419; doi: 10.1242/dmm.001040

Commentaries

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    Potential and pitfalls of stem cell therapy in old age
    David Piccin, Cindi M. Morshead
    Disease Models & Mechanisms 2010 3: 421-425; doi: 10.1242/dmm.003137
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    Sweetness and light: perspectives for rodent models of type 1 diabetes
    Philip R. Avner
    Disease Models & Mechanisms 2010 3: 426-429; doi: 10.1242/dmm.004705

Research Articles

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    Medaka as a model for human nonalcoholic steatohepatitis
    Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida
    Disease Models & Mechanisms 2010 3: 431-440; doi: 10.1242/dmm.002311
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2010 3: 439 doi: 10.1242/dmm.005355
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    A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5
    Renee M. Miller, Douglas S. Portman
    Disease Models & Mechanisms 2010 3: 441-450; doi: 10.1242/dmm.002816
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2010 3: 449 doi: 10.1242/dmm.005348
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    Multiple roles for CCR2 during fracture healing
    Zhiqing Xing, Chuanyong Lu, Diane Hu, Yan-yiu Yu, Xiaodong Wang, Celine Colnot, Mary Nakamura, Yalei Wu, Theodore Miclau, Ralph S. Marcucio
    Disease Models & Mechanisms 2010 3: 451-458; doi: 10.1242/dmm.003186
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2010 3: 457 doi: 10.1242/dmm.005512
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    Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice
    Alessandro Bartolomucci, Valeria Carola, Tiziana Pascucci, Stefano Puglisi-Allegra, Simona Cabib, Klaus-Peter Lesch, Stefano Parmigiani, Paola Palanza, Cornelius Gross
    Disease Models & Mechanisms 2010 3: 459-470; doi: 10.1242/dmm.004614
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2010 3: 468 doi: 10.1242/dmm.005405
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    Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P
    R. Lane Coffee, Jr, Charles R. Tessier, Elvin A. Woodruff III, Kendal Broadie
    Disease Models & Mechanisms 2010 3: 471-485; doi: 10.1242/dmm.004598
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2010 3: 483 doi: 10.1242/dmm.005363
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    The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model
    Silvia Curado, Elke A. Ober, Susan Walsh, Paulina Cortes-Hernandez, Heather Verkade, Carla M. Koehler, Didier Y. R. Stainier
    Disease Models & Mechanisms 2010 3: 486-495; doi: 10.1242/dmm.004390
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2010 3: 493 doi: 10.1242/dmm.005637

Research Reports

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    Ras controls melanocyte expansion during zebrafish fin stripe regeneration
    Yoonsung Lee, Gregory Nachtrab, Pai W. Klinsawat, Danyal Hami, Kenneth D. Poss
    Disease Models & Mechanisms 2010 3: 496-503; doi: 10.1242/dmm.004515
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2010 3: 502 doi: 10.1242/dmm.005843
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  • Open Access

    Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency

    Alessia Niceforo, Chiara Marioli, Fiorella Colasuonno, Stefania Petrini, Keith Massey, Marco Tartaglia, Enrico Bertini, Sandra Moreno, Claudia Compagnucci
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  • Open Access

    Genetic background modifies vulnerability to glaucoma related phenotypes in Lmx1b mutant mice

    N. G. Tolman, R. Balasubramanian, D. G. Macalinao, A. L. Kearney, K. H. MacNicoll, C. L. Montgomery, W. N. de Vries, I. J. Jackson, S. H. Cross, K. Kizhatil, K. S. Nair, S. W. M. John
    PDF
  • Open Access

    Neural crest-specific deletion of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction, and disordered breathing modelling Obstructive Sleep Apnea

    Pranidhi Baddam, Vivian Biancardi, Daniela M. Roth, Farah Eaton, Claudine Thereza-Bussolaro, Rupasri Mandal, David S. Wishart, Amy Barr, Joanna MacLean, Carlos Flores-Mir, Silvia Pagliardini, Daniel Graf
    PDF
  • Open Access

    Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

    F. W. Riemslagh, E. C. van der Toorn, R. F. M. Verhagen, A. Maas, L. W. J. Bosman, R. K. Hukema, R. Willemsen
    PDF
  • Open Access

    A muscle growth promoting treatment based on the attenuation of activin/myostatin signalling in young mice results in long-term testicular abnormalities

    Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
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Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart

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C. elegans as a disease model

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Call for papers – The RAS Pathway: Diseases, Therapeutics and Beyond

Our upcoming special issue is now welcoming submissions until 1 April 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on the targeting the RAS pathway. Find out more about the issue and how to submit your manuscript.


Interview – Kim Landry-Truchon and Nicolas Houde

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