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  Open access

September, 2009; 2 (9-10)

In This Issue

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    Dre recombinase, another tool in the mutagenesis toolbox
    Disease Models & Mechanisms 2009 2: 419
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    Bacteria benefit from mitochondrial dysfunction
    Disease Models & Mechanisms 2009 2: 419
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    Altered RNA splicing in expanded repeat disease
    Disease Models & Mechanisms 2009 2: 419
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    clueless, a possible contributor to Parkinson’s disease
    Disease Models & Mechanisms 2009 2: 419
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    Folic acid protects Wnt signaling during development
    Disease Models & Mechanisms 2009 2: 419

Research Highlights

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    Immunity: Ars2 suppresses viral infection
    Disease Models & Mechanisms 2009 2: 420
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    Cancer: yeast as a model for breast cancer
    Disease Models & Mechanisms 2009 2: 420
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    Stem cells: iPS mice
    Disease Models & Mechanisms 2009 2: 420
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    Neurodegenerative disease: preventing dyskinesia
    Disease Models & Mechanisms 2009 2: 420

Journal Club

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    PPARδ-mediated macrophage activation: a matter of fat
    Thaddeus T. Schug, Xiaoling Li
    Disease Models & Mechanisms 2009 2: 421-422; doi: 10.1242/dmm.003913

Editorials

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    Resources, repositories and rewards
    Vivian Siegel
    Disease Models & Mechanisms 2009 2: 423-425; doi: 10.1242/dmm.004259
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    Translating the cancer genome into clinically useful tools and strategies
    Federico Innocenti, Richard L. Schilsky
    Disease Models & Mechanisms 2009 2: 426-429; doi: 10.1242/dmm.004119

Community News

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    The National Postdoctoral Association
    Cathee Johnson Phillips
    Disease Models & Mechanisms 2009 2: 430-431; doi: 10.1242/dmm.004168
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    Useful Websites
    Disease Models & Mechanisms 2009 2: 431-432; doi: 10.1242/dmm.004127
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    United States Department of Defense provides biomedical research funding
    Disease Models & Mechanisms 2009 2: 432 doi: 10.1242/dmm.004028

A Model for Life

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    Taking translational research to heart: an interview with Sir Magdi Yacoub
    Nadia Rosenthal
    Disease Models & Mechanisms 2009 2: 433-435; doi: 10.1242/dmm.004176

Clinical Puzzle

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    Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?
    Barbara A. Degar, Barrett J. Rollins
    Disease Models & Mechanisms 2009 2: 436-439; doi: 10.1242/dmm.004010

Primer

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    Sea squirts and immune tolerance
    Anthony W. De Tomaso
    Disease Models & Mechanisms 2009 2: 440-445; doi: 10.1242/dmm.001156

Perspectives

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    New approaches for modelling sporadic genetic disease in the mouse
    Elizabeth M. C. Fisher, Eva Lana-Elola, Sheona D. Watson, George Vassiliou, Victor L. J. Tybulewicz
    Disease Models & Mechanisms 2009 2: 446-453; doi: 10.1242/dmm.001644
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    Rodent models of diabetic cardiomyopathy
    Heiko Bugger, E. Dale Abel
    Disease Models & Mechanisms 2009 2: 454-466; doi: 10.1242/dmm.001941

Research Articles

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    Folate rescues lithium-, homocysteine- and Wnt3A-induced vertebrate cardiac anomalies
    Mingda Han, Maria C. Serrano, Rosana Lastra-Vicente, Pilar Brinez, Ganesh Acharya, James C. Huhta, Ren Chen, Kersti K. Linask
    Disease Models & Mechanisms 2009 2: 467-478; doi: 10.1242/dmm.001438
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2009 2: 477 doi: 10.1242/dmm.003954
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    Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells
    Lisa Francione, Paige K. Smith, Sandra L. Accari, Philip E. Taylor, Paul B. Bokko, Salvatore Bozzaro, Peter L. Beech, Paul R. Fisher
    Disease Models & Mechanisms 2009 2: 479-489; doi: 10.1242/dmm.003319
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2009 2: 487 doi: 10.1242/dmm.003947
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    clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin
    Rachel T. Cox, Allan C. Spradling
    Disease Models & Mechanisms 2009 2: 490-499; doi: 10.1242/dmm.002378
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2009 2: 498 doi: 10.1242/dmm.003921
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    Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice
    Zhigang Yu, Adrienne M. Wang, Diane M. Robins, Andrew P. Lieberman
    Disease Models & Mechanisms 2009 2: 500-507; doi: 10.1242/dmm.003301
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2009 2: 506 doi: 10.1242/dmm.004218

Resource Article

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    Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice
    Konstantinos Anastassiadis, Jun Fu, Christoph Patsch, Shengbiao Hu, Stefanie Weidlich, Kristin Duerschke, Frank Buchholz, Frank Edenhofer, A. Francis Stewart
    Disease Models & Mechanisms 2009 2: 508-515; doi: 10.1242/dmm.003087
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    RESOURCE IMPACT
    Disease Models & Mechanisms 2009 2: 514 doi: 10.1242/dmm.004085

Erratum

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    Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells
    Lisa Francione, Paige K. Smith, Sandra L. Accari, Philip E. Taylor, Paul B. Bokko, Salvatore Bozzaro, Peter L. Beech, Paul R. Fisher
    Disease Models & Mechanisms 2009 2: 516 doi: 10.1242/dmm.004275
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  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
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    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
  • Open Access

    Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

    Paco López-Cuevas, Luke Deane, Yushi Yang, Chrissy L Hammond, Erika Kague
    PDF
  • Open Access

    Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

    Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
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DMM and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

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Monica Justice bids farewell to DMM

In her farewell Editorial, outgoing Editor-in-Chief Monica Justice reminds us of the past half-decade of growth and of DMM's commitment to support the disease modelling community, concluding, “The knowledge and experience I gained during my time as Senior Editor and EiC at DMM is invaluable: working within a not-for-profit community publishing environment is a joy.”


3D imaging of beta cell mass in diabetic mouse models

In their inducible mouse model of diabetes, Roostalu et al. demonstrate how quantitative light-sheet imaging can capture changes in individual islets to help pharmacological research in diabetes.

Visit our YouTube channel to watch more videos from DMM, our sister journals and the Company.


Modelling Joubert syndrome patient-derived mutations in C. elegans

In this issue’s Editor’s choice, Karen Lange and colleagues used C. elegans to model and characterise two patient-derived mutations that cause the ciliopathy Joubert syndrome.


Interview – Karen Lange

First author of our current Editor’s choice, Karen Lange takes us behind the scenes of the paper, and shares her thoughts on how the lack of both time and job security will impact her research.

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