Disease Models & Mechanisms: 2 (9-10)

September, 2009; 2 (9-10)

In This Issue

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Dre recombinase, another tool in the mutagenesis toolbox
Disease Models & Mechanisms 2009 2: 419
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Bacteria benefit from mitochondrial dysfunction
Disease Models & Mechanisms 2009 2: 419
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Altered RNA splicing in expanded repeat disease
Disease Models & Mechanisms 2009 2: 419
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clueless, a possible contributor to Parkinson’s disease
Disease Models & Mechanisms 2009 2: 419
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Folic acid protects Wnt signaling during development
Disease Models & Mechanisms 2009 2: 419

Research Highlights

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Immunity: Ars2 suppresses viral infection
Disease Models & Mechanisms 2009 2: 420
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Cancer: yeast as a model for breast cancer
Disease Models & Mechanisms 2009 2: 420
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Stem cells: iPS mice
Disease Models & Mechanisms 2009 2: 420
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Neurodegenerative disease: preventing dyskinesia
Disease Models & Mechanisms 2009 2: 420

Journal Club

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PPARδ-mediated macrophage activation: a matter of fat
Thaddeus T. Schug, Xiaoling Li

Disease Models & Mechanisms 2009 2: 421-422; doi: 10.1242/dmm.003913

Editorials

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Resources, repositories and rewards
Vivian Siegel

Disease Models & Mechanisms 2009 2: 423-425; doi: 10.1242/dmm.004259
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Translating the cancer genome into clinically useful tools and strategies
Federico Innocenti, Richard L. Schilsky

Disease Models & Mechanisms 2009 2: 426-429; doi: 10.1242/dmm.004119

Community News

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The National Postdoctoral Association
Cathee Johnson Phillips

Disease Models & Mechanisms 2009 2: 430-431; doi: 10.1242/dmm.004168
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Useful Websites
Disease Models & Mechanisms 2009 2: 431-432; doi: 10.1242/dmm.004127
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United States Department of Defense provides biomedical research funding
Disease Models & Mechanisms 2009 2: 432 doi: 10.1242/dmm.004028

A Model for Life

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Taking translational research to heart: an interview with Sir Magdi Yacoub
Nadia Rosenthal

Disease Models & Mechanisms 2009 2: 433-435; doi: 10.1242/dmm.004176

Clinical Puzzle

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Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?
Barbara A. Degar, Barrett J. Rollins

Disease Models & Mechanisms 2009 2: 436-439; doi: 10.1242/dmm.004010

Primer

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Sea squirts and immune tolerance
Anthony W. De Tomaso

Disease Models & Mechanisms 2009 2: 440-445; doi: 10.1242/dmm.001156

Perspectives

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New approaches for modelling sporadic genetic disease in the mouse
Elizabeth M. C. Fisher, Eva Lana-Elola, Sheona D. Watson, George Vassiliou, Victor L. J. Tybulewicz

Disease Models & Mechanisms 2009 2: 446-453; doi: 10.1242/dmm.001644
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Rodent models of diabetic cardiomyopathy
Heiko Bugger, E. Dale Abel

Disease Models & Mechanisms 2009 2: 454-466; doi: 10.1242/dmm.001941

Research Articles

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Folate rescues lithium-, homocysteine- and Wnt3A-induced vertebrate cardiac anomalies
Mingda Han, Maria C. Serrano, Rosana Lastra-Vicente, Pilar Brinez, Ganesh Acharya, James C. Huhta, Ren Chen, Kersti K. Linask

Disease Models & Mechanisms 2009 2: 467-478; doi: 10.1242/dmm.001438
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 477 doi: 10.1242/dmm.003954
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Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells
Lisa Francione, Paige K. Smith, Sandra L. Accari, Philip E. Taylor, Paul B. Bokko, Salvatore Bozzaro, Peter L. Beech, Paul R. Fisher

Disease Models & Mechanisms 2009 2: 479-489; doi: 10.1242/dmm.003319
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 487 doi: 10.1242/dmm.003947
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clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin
Rachel T. Cox, Allan C. Spradling

Disease Models & Mechanisms 2009 2: 490-499; doi: 10.1242/dmm.002378
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 498 doi: 10.1242/dmm.003921
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Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice
Zhigang Yu, Adrienne M. Wang, Diane M. Robins, Andrew P. Lieberman

Disease Models & Mechanisms 2009 2: 500-507; doi: 10.1242/dmm.003301
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 506 doi: 10.1242/dmm.004218

Resource Article

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Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice
Konstantinos Anastassiadis, Jun Fu, Christoph Patsch, Shengbiao Hu, Stefanie Weidlich, Kristin Duerschke, Frank Buchholz, Frank Edenhofer, A. Francis Stewart

Disease Models & Mechanisms 2009 2: 508-515; doi: 10.1242/dmm.003087
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RESOURCE IMPACT
Disease Models & Mechanisms 2009 2: 514 doi: 10.1242/dmm.004085

Erratum

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Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells
Lisa Francione, Paige K. Smith, Sandra L. Accari, Philip E. Taylor, Paul B. Bokko, Salvatore Bozzaro, Peter L. Beech, Paul R. Fisher

Disease Models & Mechanisms 2009 2: 516 doi: 10.1242/dmm.004275

This issue

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Open Access

Impaired muscle morphology in a Drosophila model of myosin storage myopathy was supressed by overexpression of an E3 ubiquitin ligase

Martin Dahl-Halvarsson, Montse Olive, Malgorzata Pokrzywa, Michaela Norum, Katarina Ejeskär, Homa Tajsharghi

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Interpreting the pathogenicity of Joubert Syndrome missense variants in Caenorhabditis elegans

Karen I. Lange, Sofia Tsiropoulou, Katarzyna Kucharska, Oliver E. Blacque

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3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II

Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Thomas Klein, Niels Vrang, Jacob Jelsing, Jacob Hecksher-Sørensen

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Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis

Kim Landry-Truchon, Nicolas Houde, Mickaël Lhuillier, Louis Charron, Alice Hadchouel, Christophe Delacourt, William D. Foulkes, Louise Galmiche-Rolland, Lucie Jeannotte

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Open Access

Predicting experimental success: A retrospective case-control study using the rat intraluminal thread model of stroke

Lisa Liebenstund, Mark Coburn, Christina Fitzner, Antje Willuweit, Karl-Josef Langen, Jingjin Liu, Michael Veldeman, Anke Höllig

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Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.

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Interview – Gideon Hughes

Gideon Hughes is the first author of our current most-read article, which details a machine learning approach to study disordered movement in a zebrafish model of Parkinsons. Find out more about Gideon, his work and life away from the bench.

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