Disease Models & Mechanisms: 2 (9-10)

September, 2009; 2 (9-10)

In This Issue

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Dre recombinase, another tool in the mutagenesis toolbox
Disease Models & Mechanisms 2009 2: 419
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Bacteria benefit from mitochondrial dysfunction
Disease Models & Mechanisms 2009 2: 419
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Altered RNA splicing in expanded repeat disease
Disease Models & Mechanisms 2009 2: 419
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clueless, a possible contributor to Parkinson’s disease
Disease Models & Mechanisms 2009 2: 419
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Folic acid protects Wnt signaling during development
Disease Models & Mechanisms 2009 2: 419

Research Highlights

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Immunity: Ars2 suppresses viral infection
Disease Models & Mechanisms 2009 2: 420
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Cancer: yeast as a model for breast cancer
Disease Models & Mechanisms 2009 2: 420
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Stem cells: iPS mice
Disease Models & Mechanisms 2009 2: 420
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Neurodegenerative disease: preventing dyskinesia
Disease Models & Mechanisms 2009 2: 420

Journal Club

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PPARδ-mediated macrophage activation: a matter of fat
Thaddeus T. Schug, Xiaoling Li

Disease Models & Mechanisms 2009 2: 421-422; doi: 10.1242/dmm.003913

Editorials

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Resources, repositories and rewards
Vivian Siegel

Disease Models & Mechanisms 2009 2: 423-425; doi: 10.1242/dmm.004259
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Translating the cancer genome into clinically useful tools and strategies
Federico Innocenti, Richard L. Schilsky

Disease Models & Mechanisms 2009 2: 426-429; doi: 10.1242/dmm.004119

Community News

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The National Postdoctoral Association
Cathee Johnson Phillips

Disease Models & Mechanisms 2009 2: 430-431; doi: 10.1242/dmm.004168
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Useful Websites
Disease Models & Mechanisms 2009 2: 431-432; doi: 10.1242/dmm.004127
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United States Department of Defense provides biomedical research funding
Disease Models & Mechanisms 2009 2: 432 doi: 10.1242/dmm.004028

A Model for Life

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Taking translational research to heart: an interview with Sir Magdi Yacoub
Nadia Rosenthal

Disease Models & Mechanisms 2009 2: 433-435; doi: 10.1242/dmm.004176

Clinical Puzzle

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Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?
Barbara A. Degar, Barrett J. Rollins

Disease Models & Mechanisms 2009 2: 436-439; doi: 10.1242/dmm.004010

Primer

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Sea squirts and immune tolerance
Anthony W. De Tomaso

Disease Models & Mechanisms 2009 2: 440-445; doi: 10.1242/dmm.001156

Perspectives

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New approaches for modelling sporadic genetic disease in the mouse
Elizabeth M. C. Fisher, Eva Lana-Elola, Sheona D. Watson, George Vassiliou, Victor L. J. Tybulewicz

Disease Models & Mechanisms 2009 2: 446-453; doi: 10.1242/dmm.001644
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Rodent models of diabetic cardiomyopathy
Heiko Bugger, E. Dale Abel

Disease Models & Mechanisms 2009 2: 454-466; doi: 10.1242/dmm.001941

Research Articles

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Folate rescues lithium-, homocysteine- and Wnt3A-induced vertebrate cardiac anomalies
Mingda Han, Maria C. Serrano, Rosana Lastra-Vicente, Pilar Brinez, Ganesh Acharya, James C. Huhta, Ren Chen, Kersti K. Linask

Disease Models & Mechanisms 2009 2: 467-478; doi: 10.1242/dmm.001438
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 477 doi: 10.1242/dmm.003954
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Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells
Lisa Francione, Paige K. Smith, Sandra L. Accari, Philip E. Taylor, Paul B. Bokko, Salvatore Bozzaro, Peter L. Beech, Paul R. Fisher

Disease Models & Mechanisms 2009 2: 479-489; doi: 10.1242/dmm.003319
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 487 doi: 10.1242/dmm.003947
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clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin
Rachel T. Cox, Allan C. Spradling

Disease Models & Mechanisms 2009 2: 490-499; doi: 10.1242/dmm.002378
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 498 doi: 10.1242/dmm.003921
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Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice
Zhigang Yu, Adrienne M. Wang, Diane M. Robins, Andrew P. Lieberman

Disease Models & Mechanisms 2009 2: 500-507; doi: 10.1242/dmm.003301
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 506 doi: 10.1242/dmm.004218

Resource Article

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Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice
Konstantinos Anastassiadis, Jun Fu, Christoph Patsch, Shengbiao Hu, Stefanie Weidlich, Kristin Duerschke, Frank Buchholz, Frank Edenhofer, A. Francis Stewart

Disease Models & Mechanisms 2009 2: 508-515; doi: 10.1242/dmm.003087
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RESOURCE IMPACT
Disease Models & Mechanisms 2009 2: 514 doi: 10.1242/dmm.004085

Erratum

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Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells
Lisa Francione, Paige K. Smith, Sandra L. Accari, Philip E. Taylor, Paul B. Bokko, Salvatore Bozzaro, Peter L. Beech, Paul R. Fisher

Disease Models & Mechanisms 2009 2: 516 doi: 10.1242/dmm.004275

This issue

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Open Access

Genetic predisposition for increased red blood cell distribution width is an early risk factor for cardiovascular and renal comorbidities

Xi Cheng, Blair Mell, Ahmad Alimadadi, Sarah Galla, Cameron G. McCarthy, Saroj Chakraborty, Venkatesha Basrur, Bina Joe

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The transcription factor Nurr1 is up-regulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice

Valeria Valsecchi, Marina Boido, Francesca Montarolo, Michela Guglielmotto, Simona Perga, Serena Martire, Santina Cutrupi, Andrea Iannello, Nadia Gionchiglia, Elena Signorino, Andrea Calvo, Giuseppe Fuda, Adriano Chiò, Antonio Bertolotto, Alessandro Vercelli

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Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive (SS) but not Dahl salt-resistant (SR) rats

Eunjo Lee, Namkyung Kim, Jinjoo Kang, Sangwon Yoon, Hae-Ahm Lee, Hanna Jung, Sang-Hyun Kim, Inkyeom Kim

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Deficiency in the endocytic adaptor proteins PHETA1/2 impair renal and craniofacial development

Kristin M. Ates, Tong Wang, Trevor Moreland, Rajalakshmi Veeranan-Karmegam, Manxiu Ma, Chelsi Jeter, Priya Anand, Wolfgang Wenzel, Hyung-Goo Kim, Lynne A. Wolfe, Joshi A. Stephen, David R. Adams, Thomas Markello, Cynthia J. Tifft, Robert Settlage, William A. Gahl, Graydon B. Gonsalvez, May Christine Malicdan, Heather Flanagan-Steet, Y. Albert Pan

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Open Access

Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure

Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G. Tolman, Syed Hameed, Yusef Seymens, Eric Dang, Anil K. Mandal, Sirisha Senthil, Rohit C. Khanna, Meha Kabra, Inderjeet Kaur, Simon W. M. John, Subhabrata Chakrabarti, K. Saidas Nair

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Other journals from The Company of Biologists

DMM and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.

A Model for Life – Elizabeth McNally and Louis Kunkel

Human geneticist and cardiologist Elizabeth McNally discusses her first experiences in science and the effort we all need to make to facilitate diversity in science, while Louis Kunkel tells us about talks about his discovery of dystrophin.

A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping

On the cover of our special issue, Demonbreun et al. present muscle fiber typing from a newly created mouse model of limb-girdle muscular dystrophy generated by gene editing.

Non-canonical autophagy in innate immune defence in vivo

preLighter Kirsty Hooper, The Babraham Institute, Cambridge, UK, discusses a preprint showing that loss of non-canonical autophagy in mice increases sensitivity to influenza A virus infection.

The Biology Open transfer option

DMM authors can transfer their submission to our sister journal Biology Open with just one click. An online Open Access journal, BiO also welcomes direct submissions and focuses on the swift publication of high-quality, sound research. Recent disease modelling highlights in BiO include work by Liu et al. investigating transgenic replenishment strategies targeting myocardial and non-myocardial tissues in the zebrafish. Find out more about how to transfer.

Editor’s choice

Highlighted by the Guest editors of our special issue, Grunwald and colleagues use zebrafish to investigate interactions among ryanodine receptor isotypes in muscle development and function, while Claire Wood et al. tests the mdx:Cmah^−/− mouse to investigate growth and skeletal development in Duchenne muscular dystrophy.

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