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  You have access

  Open access

March 1, 2009; 2 (3-4)

In This Issue

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    Myelin maintenance under microRNA control
    Disease Models & Mechanisms 2009 2: 93
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    Endothelial cells key in cerebral angiogenesis
    Disease Models & Mechanisms 2009 2: 93
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    Human stem cell-derived neurons model ALS
    Disease Models & Mechanisms 2009 2: 93
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    Telomere dysfunction in cancer and skin disease
    Disease Models & Mechanisms 2009 2: 93
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    The connexin connection to fertility
    Disease Models & Mechanisms 2009 2: 93

Research Highlights

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    Infectious disease: parasites poke holes to enable escape
    Disease Models & Mechanisms 2009 2: 94
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    Cancer: early intervention targets N-myc
    Disease Models & Mechanisms 2009 2: 94
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    Neurodegeneration: protein misfolding in a worm model of ALS
    Disease Models & Mechanisms 2009 2: 94
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    Metabolic disease: maternal diet influences fetal fatty liver
    Disease Models & Mechanisms 2009 2: 94
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    Stem cells: ratting out ES cells
    Disease Models & Mechanisms 2009 2: 94-95;
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    Neurobehavioral disease: complex human genetics recapitulated in mice
    Disease Models & Mechanisms 2009 2: 95
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    Cancer: understanding cancer on the fly
    Disease Models & Mechanisms 2009 2: 95

Editorials

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    Courting change
    Vivian Siegel
    Disease Models & Mechanisms 2009 2: 97-99; doi: 10.1242/dmm.002741
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    Drinking from the firehose of scientific publishing
    Chris Patil, Vivian Siegel
    Disease Models & Mechanisms 2009 2: 100-102; doi: 10.1242/dmm.002758
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    Disease models and mechanisms in the classroom
    Aaron D. Gitler
    Disease Models & Mechanisms 2009 2: 103-106; doi: 10.1242/dmm.002600
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    Visualizing anti-tumor immune responses in vivo
    Jean Y. Perentes, Dan G. Duda, Rakesh K. Jain
    Disease Models & Mechanisms 2009 2: 107-110; doi: 10.1242/dmm.001842

Community News

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    Mouse Models of Human Cancers Consortium (MMHCC) from the NCI
    Cheryl Marks
    Disease Models & Mechanisms 2009 2: 111 doi: 10.1242/dmm.002725
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    Congratulations to recent DMM Research Presentation Grant awardees
    Disease Models & Mechanisms 2009 2: 111-112; doi: 10.1242/dmm.002691
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    USEFUL RESOURCES
    Disease Models & Mechanisms 2009 2: 112 doi: 10.1242/dmm.002709

A Model For Life

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    The cell cycle and beyond: an interview with Paul Nurse
    Jim Smith
    Disease Models & Mechanisms 2009 2: 113-115; doi: 10.1242/dmm.002592

Clinical Puzzle

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    Lesch-Nyhan disease: from mechanism to model and back again
    H. A. Jinnah
    Disease Models & Mechanisms 2009 2: 116-121; doi: 10.1242/dmm.002543

Commentary

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    Mouse models of Huntington disease: variations on a theme
    Dagmar E. Ehrnhoefer, Stefanie L. Butland, Mahmoud A. Pouladi, Michael R. Hayden
    Disease Models & Mechanisms 2009 2: 123-129; doi: 10.1242/dmm.002451

Perspective

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    Defining the potential for cell therapy for vascular disease using animal models
    Rajiv Gulati, Robert D. Simari
    Disease Models & Mechanisms 2009 2: 130-137; doi: 10.1242/dmm.000562

Research Articles

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    Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells
    Gerdine J. Stout, Maria A. Blasco
    Disease Models & Mechanisms 2009 2: 139-156; doi: 10.1242/dmm.002121
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2009 2: 154 doi: 10.1242/dmm.002675
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    Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia
    Dan Tong, Deanne Colley, Renee Thoo, Tony Y. Li, Isabelle Plante, Dale W. Laird, Donglin Bai, Gerald M. Kidder
    Disease Models & Mechanisms 2009 2: 157-167; doi: 10.1242/dmm.000935
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2009 2: 166 doi: 10.1242/dmm.002667
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    Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations
    Gwénola Boulday, Anne Blécon, Nathalie Petit, Fabrice Chareyre, Luis A. Garcia, Michiko Niwa-Kawakita, Marco Giovannini, Elisabeth Tournier-Lasserve
    Disease Models & Mechanisms 2009 2: 168-177; doi: 10.1242/dmm.001263
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2009 2: 175 doi: 10.1242/dmm.002584
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    miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination
    Shu-Ting Lin, Ying-Hui Fu
    Disease Models & Mechanisms 2009 2: 178-188; doi: 10.1242/dmm.001065
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2009 2: 187 doi: 10.1242/dmm.002576

Research Reports

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    Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
    Saravanan Karumbayaram, Theresa K. Kelly, Andres A. Paucar, Anne J. T. Roe, Joy A. Umbach, Andrew Charles, Steven A. Goldman, Harley I. Kornblum, Martina Wiedau-Pazos
    Disease Models & Mechanisms 2009 2: 189-195; doi: 10.1242/dmm.002113
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    TRANSLATIONAL IMPACT
    Disease Models & Mechanisms 2009 2: 194 doi: 10.1242/dmm.002683
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    A comparison of the bone and growth phenotype of mdx, mdx:cmah−/− and mdx:utrn+/− murine models with the C57BL10 wildtype mouse

    C. L. Wood, K. J. Suchaki, R. van 't Hof, W. P. Cawthorn, S. Dillon, V. Straub, S. C. Wong, S. F. Ahmed, C. Farquharson
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    Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

    Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger
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    A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries

    Omkara Lakshmi Veeranki, Zhimin Tong, Alicia Mejia, Anuj Verma, Riham Katkhuda, Roland Bassett, Tae-Beom Kim, Jing Wang, Wenhua Lang, Barbara Mino, Luisa Solis, Charles Kingsley, William Norton, Ramesh Tailor, Ji Yuan Wu, Sunil Krishnan, Steven H. Lin, Mariela Blum, Wayne Hofstetter, Jaffer Ajani, Scott Kopetz, Dipen Maru
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  • Open Access

    A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

    Alberto Rissone, Erin Jimenez, Kevin Bishop, Blake Carrington, Claire Slevin, Stephen M. Wincovitch, Raman Sood, Fabio Candotti, Shawn M. Burgess
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    Notch4 activation aggravates NF-kappa B mediated inflammation in HIV-1 associated Nephropathy

    Rajni Vaid Puri, Sireesha Yerrathota, Trisha Home, Jessica Y. Idowu, Praveen V. Chakravarthi, Christopher J. Ward, Pravin Singhal, Gregory B. Vanden Heuvel, Timothy A. Fields, Madhulika Sharma
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