Disease Models & Mechanisms: 2 (3-4)

March, 2009; 2 (3-4)

In This Issue

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Myelin maintenance under microRNA control
Disease Models & Mechanisms 2009 2: 93
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Endothelial cells key in cerebral angiogenesis
Disease Models & Mechanisms 2009 2: 93
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Human stem cell-derived neurons model ALS
Disease Models & Mechanisms 2009 2: 93
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Telomere dysfunction in cancer and skin disease
Disease Models & Mechanisms 2009 2: 93
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The connexin connection to fertility
Disease Models & Mechanisms 2009 2: 93

Research Highlights

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Infectious disease: parasites poke holes to enable escape
Disease Models & Mechanisms 2009 2: 94
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Cancer: early intervention targets N-myc
Disease Models & Mechanisms 2009 2: 94
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Neurodegeneration: protein misfolding in a worm model of ALS
Disease Models & Mechanisms 2009 2: 94
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Metabolic disease: maternal diet influences fetal fatty liver
Disease Models & Mechanisms 2009 2: 94
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Stem cells: ratting out ES cells
Disease Models & Mechanisms 2009 2: 94-95;
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Neurobehavioral disease: complex human genetics recapitulated in mice
Disease Models & Mechanisms 2009 2: 95
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Cancer: understanding cancer on the fly
Disease Models & Mechanisms 2009 2: 95

Editorials

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Courting change
Vivian Siegel

Disease Models & Mechanisms 2009 2: 97-99; doi: 10.1242/dmm.002741
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Drinking from the firehose of scientific publishing
Chris Patil, Vivian Siegel

Disease Models & Mechanisms 2009 2: 100-102; doi: 10.1242/dmm.002758
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Disease models and mechanisms in the classroom
Aaron D. Gitler

Disease Models & Mechanisms 2009 2: 103-106; doi: 10.1242/dmm.002600
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Visualizing anti-tumor immune responses in vivo
Jean Y. Perentes, Dan G. Duda, Rakesh K. Jain

Disease Models & Mechanisms 2009 2: 107-110; doi: 10.1242/dmm.001842

Community News

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Mouse Models of Human Cancers Consortium (MMHCC) from the NCI
Cheryl Marks

Disease Models & Mechanisms 2009 2: 111 doi: 10.1242/dmm.002725
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Congratulations to recent DMM Research Presentation Grant awardees
Disease Models & Mechanisms 2009 2: 111-112; doi: 10.1242/dmm.002691
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USEFUL RESOURCES
Disease Models & Mechanisms 2009 2: 112 doi: 10.1242/dmm.002709

A Model For Life

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The cell cycle and beyond: an interview with Paul Nurse
Jim Smith

Disease Models & Mechanisms 2009 2: 113-115; doi: 10.1242/dmm.002592

Clinical Puzzle

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Lesch-Nyhan disease: from mechanism to model and back again
H. A. Jinnah

Disease Models & Mechanisms 2009 2: 116-121; doi: 10.1242/dmm.002543

Commentary

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Mouse models of Huntington disease: variations on a theme
Dagmar E. Ehrnhoefer, Stefanie L. Butland, Mahmoud A. Pouladi, Michael R. Hayden

Disease Models & Mechanisms 2009 2: 123-129; doi: 10.1242/dmm.002451

Perspective

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Defining the potential for cell therapy for vascular disease using animal models
Rajiv Gulati, Robert D. Simari

Disease Models & Mechanisms 2009 2: 130-137; doi: 10.1242/dmm.000562

Research Articles

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Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells
Gerdine J. Stout, Maria A. Blasco

Disease Models & Mechanisms 2009 2: 139-156; doi: 10.1242/dmm.002121
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 154 doi: 10.1242/dmm.002675
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Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia
Dan Tong, Deanne Colley, Renee Thoo, Tony Y. Li, Isabelle Plante, Dale W. Laird, Donglin Bai, Gerald M. Kidder

Disease Models & Mechanisms 2009 2: 157-167; doi: 10.1242/dmm.000935
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 166 doi: 10.1242/dmm.002667
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Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations
Gwénola Boulday, Anne Blécon, Nathalie Petit, Fabrice Chareyre, Luis A. Garcia, Michiko Niwa-Kawakita, Marco Giovannini, Elisabeth Tournier-Lasserve

Disease Models & Mechanisms 2009 2: 168-177; doi: 10.1242/dmm.001263
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 175 doi: 10.1242/dmm.002584
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miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination
Shu-Ting Lin, Ying-Hui Fu

Disease Models & Mechanisms 2009 2: 178-188; doi: 10.1242/dmm.001065
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 187 doi: 10.1242/dmm.002576

Research Reports

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Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
Saravanan Karumbayaram, Theresa K. Kelly, Andres A. Paucar, Anne J. T. Roe, Joy A. Umbach, Andrew Charles, Steven A. Goldman, Harley I. Kornblum, Martina Wiedau-Pazos

Disease Models & Mechanisms 2009 2: 189-195; doi: 10.1242/dmm.002113
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TRANSLATIONAL IMPACT
Disease Models & Mechanisms 2009 2: 194 doi: 10.1242/dmm.002683

This issue

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Open Access

Joint development recovery on resumption of embryonic movement following paralysis

Rebecca A. Rolfe, David Scanlon O'Callaghan, Paula Murphy

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Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Adeline Bourgeois, Pedro Magalhães, Maria Kuzma-Kuzniarska, Celine Lesaulnier, Martin Rezko, Edwige Declercq, Petra Zürbig, Alain Doucet, Muriel Umbhauer, Silvia Cereghini

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An Fgfr3-activating mutation in immature osteoblasts affects the appendicular and craniofacial skeleton

Martin Biosse Duplan, Emilie Dambroise, Valentin Estibals, Joelle Veziers, Jérome Guicheux, Laurence Legeai-Mallet

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Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome

Beverly A. Karpinski, Thomas M. Maynard, Corey A. Bryan, Gelila Yitsege, Anelia Horvath, Norman H. Lee, Sally A. Moody, Anthony-Samuel LaMantia

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Sex differences in insulin resistance but not peripheral neuropathy in a diet-induced prediabetes mouse model

Sarah E. Elzinga, Masha G. Savelieff, Phillipe D. O'Brien, Faye E. Mendelson, John M. Hayes, Eva L. Feldman

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DMM and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.

The twin pillars of Disease Models & Mechanisms

In her first Editorial as Editor-in-Chief, Liz Patton sets out her vision and priorities for DMM focusing on four thematic challenges: mechanisms of disease, innovative technologies, disease progression through time and therapy.

Extended deadline - The RAS Pathway: Diseases, Therapeutics and Beyond

Our upcoming special issue is welcoming submissions until 3 May 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on the targeting the RAS pathway.

Find out more about the issue and how to submit your manuscript.

Perspective - Modelling the developmental origins of paediatric cancer to improve patient outcomes

James Amatruda authors our first Perspective, discussing some of the key challenges in paediatric cancer from his perspective as a physician-scientist.

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities

In this issue’s Editor’s choice, Ketan Patel and colleagues describe how even brief exposure to muscle-growth-promoting treatments exerts a long-term detrimental effect on the testes, and test promising therapeutics to mitigate this side-effect.

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