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RESEARCH ARTICLE
Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart
Emilie Auxerre-Plantié, Tanja Nielsen, Marcel Grunert, Olga Olejniczak, Andreas Perrot, Cemil Özcelik, Dennis Harries, Faramarz Matinmehr, Cristobal Dos Remedios, Christian Mühlfeld, Theresia Kraft, Rolf Bodmer, Georg Vogler, Silke R. Sperling
Disease Models & Mechanisms 2020 13: dmm045377 doi: 10.1242/dmm.045377 Published 18 December 2020
Emilie Auxerre-Plantié
1Cardiovascular Genetics, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
2Berlin Institute of Health (BIH), Berlin, Germany
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Tanja Nielsen
1Cardiovascular Genetics, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
2Berlin Institute of Health (BIH), Berlin, Germany
3DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany
4Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
5Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
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  • ORCID record for Tanja Nielsen
Marcel Grunert
1Cardiovascular Genetics, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
2Berlin Institute of Health (BIH), Berlin, Germany
3DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany
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  • ORCID record for Marcel Grunert
Olga Olejniczak
1Cardiovascular Genetics, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
2Berlin Institute of Health (BIH), Berlin, Germany
3DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany
5Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
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Andreas Perrot
1Cardiovascular Genetics, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
6Experimental and Clinical Research Center, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
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Cemil Özcelik
6Experimental and Clinical Research Center, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
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Dennis Harries
7Medical School of Hannover, Institute of Molecular and Cell Physiology, 30625 Hannover, Germany
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Faramarz Matinmehr
7Medical School of Hannover, Institute of Molecular and Cell Physiology, 30625 Hannover, Germany
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Cristobal Dos Remedios
8Anatomy and Histology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, Sydney, New South Wales 2006, Australia
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Christian Mühlfeld
9Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany
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Theresia Kraft
7Medical School of Hannover, Institute of Molecular and Cell Physiology, 30625 Hannover, Germany
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Rolf Bodmer
4Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
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Georg Vogler
1Cardiovascular Genetics, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
4Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
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  • For correspondence: gvogler@sbpdiscovery.org silke.sperling@charite.de
Silke R. Sperling
1Cardiovascular Genetics, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
2Berlin Institute of Health (BIH), Berlin, Germany
3DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany
5Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
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  • For correspondence: gvogler@sbpdiscovery.org silke.sperling@charite.de

Handling Editor: Tatsushi Igaki

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Article Information

vol. 13 no. 12, dmm045377

DOI 
https://doi.org/10.1242/dmm.045377
PubMed 
33033063

Published By 
The Company of Biologists Ltd
Print ISSN 
1754-8403
Online ISSN 
1754-8411
History 
  • Received April 28, 2020
  • Accepted October 1, 2020
  • Published online December 18, 2020.
Posted online 
October 08, 2020
Copyright & Usage 
© 2020. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Article Versions

  • Previous version (October 8, 2020 - 08:43).
  • You are viewing the most recent version of this article.

Author Information

  1. Emilie Auxerre-Plantié1,2,*,§,
  2. Tanja Nielsen1,2,3,4,5,§,
  3. Marcel Grunert1,2,3,§,
  4. Olga Olejniczak1,2,3,5,
  5. Andreas Perrot1,6,
  6. Cemil Özcelik6,‡,
  7. Dennis Harries7,
  8. Faramarz Matinmehr7,
  9. Cristobal Dos Remedios8,
  10. Christian Mühlfeld9,
  11. Theresia Kraft7,
  12. Rolf Bodmer4,
  13. Georg Vogler1,4,¶ and
  14. Silke R. Sperling1,2,3,5,¶
  1. 1Cardiovascular Genetics, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
  2. 2Berlin Institute of Health (BIH), Berlin, Germany
  3. 3DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany
  4. 4Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
  5. 5Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
  6. 6Experimental and Clinical Research Center, Charité – Universitätsmedizin Berlin, 13125 Berlin, Germany
  7. 7Medical School of Hannover, Institute of Molecular and Cell Physiology, 30625 Hannover, Germany
  8. 8Anatomy and Histology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, Sydney, New South Wales 2006, Australia
  9. 9Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany
  1. ↵¶Authors for correspondence (gvogler{at}sbpdiscovery.org; silke.sperling{at}charite.de)
  • ↵* Present address: GReD laboratory, Université Clermont Auvergne, 63000 Clermont-Ferrand, France.

  • ↵‡ Present address: Helios Klinikum Emil von Behring GmbH, Department of Internal Medicine I – Cardiology, 63000 Berlin, Germany.

  • ↵§ These authors contributed equally to this work

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Keywords

  • Congenital heart disease
  • Cardiomyopathy
  • CG14964
  • Myomesin
  • Candidate gene

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RESEARCH ARTICLE
Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart
Emilie Auxerre-Plantié, Tanja Nielsen, Marcel Grunert, Olga Olejniczak, Andreas Perrot, Cemil Özcelik, Dennis Harries, Faramarz Matinmehr, Cristobal Dos Remedios, Christian Mühlfeld, Theresia Kraft, Rolf Bodmer, Georg Vogler, Silke R. Sperling
Disease Models & Mechanisms 2020 13: dmm045377 doi: 10.1242/dmm.045377 Published 18 December 2020
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RESEARCH ARTICLE
Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart
Emilie Auxerre-Plantié, Tanja Nielsen, Marcel Grunert, Olga Olejniczak, Andreas Perrot, Cemil Özcelik, Dennis Harries, Faramarz Matinmehr, Cristobal Dos Remedios, Christian Mühlfeld, Theresia Kraft, Rolf Bodmer, Georg Vogler, Silke R. Sperling
Disease Models & Mechanisms 2020 13: dmm045377 doi: 10.1242/dmm.045377 Published 18 December 2020

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