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RESEARCH ARTICLE
3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Thomas Klein, Niels Vrang, Jacob Jelsing, Jacob Hecksher-Sørensen
Disease Models & Mechanisms 2020 13: dmm045351 doi: 10.1242/dmm.045351 Published 18 December 2020
Urmas Roostalu
1Gubra ApS, 2970 Hørsholm, Denmark
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Jacob Lercke Skytte
1Gubra ApS, 2970 Hørsholm, Denmark
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Casper Gravesen Salinas
1Gubra ApS, 2970 Hørsholm, Denmark
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Thomas Klein
2Department of CardioMetabolic, Diseases, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany
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Niels Vrang
1Gubra ApS, 2970 Hørsholm, Denmark
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Jacob Jelsing
1Gubra ApS, 2970 Hørsholm, Denmark
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Jacob Hecksher-Sørensen
1Gubra ApS, 2970 Hørsholm, Denmark
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  • ORCID record for Jacob Hecksher-Sørensen
  • For correspondence: jhs@gubra.dk

Handling Editor: Monica J. Justice

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Article Information

vol. 13 no. 12, dmm045351

DOI 
https://doi.org/10.1242/dmm.045351
PubMed 
33158929

Published By 
The Company of Biologists Ltd
Print ISSN 
1754-8403
Online ISSN 
1754-8411
History 
  • Received May 1, 2020
  • Accepted October 16, 2020
  • Published online December 18, 2020.
Posted online 
November 06, 2020
Copyright & Usage 
© 2020. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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  • Previous version (November 6, 2020 - 02:22).
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Author Information

  1. Urmas Roostalu1,
  2. Jacob Lercke Skytte1,
  3. Casper Gravesen Salinas1,
  4. Thomas Klein2,
  5. Niels Vrang1,
  6. Jacob Jelsing1 and
  7. Jacob Hecksher-Sørensen1,*
  1. 1Gubra ApS, 2970 Hørsholm, Denmark
  2. 2Department of CardioMetabolic, Diseases, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany
  1. ↵*Author for correspondence (jhs{at}gubra.dk)
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    Keywords

    • Light-sheet fluorescence microscopy
    • Tissue clearing
    • Beta cells
    • Insulin
    • Inflammation

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    RESEARCH ARTICLE
    3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
    Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Thomas Klein, Niels Vrang, Jacob Jelsing, Jacob Hecksher-Sørensen
    Disease Models & Mechanisms 2020 13: dmm045351 doi: 10.1242/dmm.045351 Published 18 December 2020
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    RESEARCH ARTICLE
    3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
    Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Thomas Klein, Niels Vrang, Jacob Jelsing, Jacob Hecksher-Sørensen
    Disease Models & Mechanisms 2020 13: dmm045351 doi: 10.1242/dmm.045351 Published 18 December 2020

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