FIRST PERSON
AT A GLANCE
- Modeling hematopoietic disorders in zebrafish
Summary: This At A Glance article and poster summarize the last 20 years of research in zebrafish models for hematopoietic disorders, highlighting how these models were created and are being applied for translational research.
REVIEW
- Experimental models and tools to tackle glioblastoma
Summary: This Review discusses preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems.
RESEARCH ARTICLES
- Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish
Summary: Diabetes is associated with vascular and neurological impairments. The authors show that an NO donor ameliorates the glucose-exposure-induced dysfunction in the tectal neurovascular unit and whole-organism behaviour.
- Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours
Summary: Aβ overexpression in a second-generation Alzheimer's disease model results in alterations in anxiety-type behaviours, as well as gamma oscillations, neural organisation and Grin2b expression in the prefrontal cortex.
- Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia
Summary: Adapting a spontaneous, genetically heterogenous T-ALL model to preclinical testing demonstrated that response to therapeutic anti-Notch1 antibodies was determined by Notch1 mutational status and that PD-1 immune checkpoint blockade alone lacked anti-tumor activity.
- A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain
Summary: New phenotypes are revealed by a GLUT1 deficiency mutant mouse model carrying a missense mutation in Glut1.
- Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model
Editor's choice: Using antagonistic lactobacilli, C. albicans pathogenicity was reduced to a minimum in an in vitro gut model consisting of enterocytes and goblet cells.
- Clinical pathologies of bone fracture modelled in zebrafish
Summary: The effect of osteogenesis imperfecta, bisphosphonate treatment and bacterial infection on phases of bone fracture repair are determined using a zebrafish fracture model.
PREPRINT HIGHLIGHTS
This issue
Other journals from The Company of Biologists
DMM and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
Supporting communities at The Company of Biologists
Throughout all fields of biology there are vibrant, active and engaged communities. We’re proud to host, alongside our journals, three dedicated community sites to extend our support to biologists everywhere. Find out more about the Node, preLights and FocalPlane.
Editor’s Choice - Biomimetic device and foreign body reaction cooperate for efficient tumour cell capture in murine advanced ovarian cancer
Miguel Abal and colleagues implanted a biomimetic device to recapitulate the peritoneal metastatic niche and to efficiently capture disseminating ovarian cancer cells in vivo.
Interviews – Alec, Sara, Dimitrije, Amélie and Malabika
DMM first authors Alec Nickolls, Sara Ibrahim, Dimitrije Stanković, Amélie Bacle and Malabika Chakrabarti all share the stories behind their latest research.
Understanding the impact of fibroblast heterogeneity on skin fibrosis
In their new Review, Michael Longaker and colleagues discuss the complex aspects of fibroblast heterogeneity and the different roles of fibroblast subpopulations to help overcome skin scarring and fibrosis.