This issue is currently being compiled. Articles in their final version of record are published here as soon as they are ready. The most recent articles appear at the top of the relevant section.
FIRST PERSON
AT A GLANCE
- Modeling hematopoietic disorders in zebrafish
Summary: This At A Glance article and poster summarize the last 20 years of research in zebrafish models for hematopoietic disorders, highlighting how these models were created and are being applied for translational research.
REVIEW
- Experimental models and tools to tackle glioblastoma
Summary: This Review discusses preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems.
RESEARCH ARTICLES
- Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia
Summary: Adapting a spontaneous, genetically heterogenous T-ALL model to preclinical testing demonstrated that response to therapeutic anti-Notch1 antibodies was determined by Notch1 mutational status and that PD-1 immune checkpoint blockade alone lacked anti-tumor activity.
- A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain
Summary: New phenotypes are revealed by a GLUT1 deficiency mutant mouse model carrying a missense mutation in Glut1.
- Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model
Summary: Using antagonistic lactobacilli, C. albicans pathogenicity was reduced to a minimum in an in vitro gut model consisting of enterocytes and goblet cells.
- Clinical pathologies of bone fracture modelled in zebrafish
Summary: The effect of osteogenesis imperfecta, bisphosphonate treatment and bacterial infection on phases of bone fracture repair are determined using a zebrafish fracture model.
This issue
Other journals from The Company of Biologists
Editor’s Choice - Development of mouse models of angiosarcoma driven by p53
Valerie Brunton and colleagues report that deletion of p53 in endothelial cells leads to reliable angiosarcoma generation, which, along with establishment of a transplantation model, provides a novel approach for testing potential new therapeutics.
Organoids are self-organizing tissues derived from stem cells that provide a unique system to examine organ development, homeostasis and disease. This At a Glance by Madeline Lancaster and Meritxell Huch summarises the current organoid models of several human diseases, and discusses future prospects for these technologies.
An injection-based chordoma model in zebrafish shows that the hypothesized chordoma oncogene brachyury is insufficient, whereas EGFR and VEGFR2 are sufficient, to trigger notochord hyperplasia, find Alexa Burger and colleagues.
First Person interviews
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with Marie Rodinova and Christiaan Veerman.
DMM partners with Publons for peer reviewer recognition
Disease Models & Mechanisms is pleased to announce a new partnership with Publons, part of the Web of Science Group (a Clarivate Analytics company). Publons gives reviewers formal recognition of their peer review contributions using the Reviewer Recognition Service.
preLights - Injury stimulates stem cells to resist radiation-induced apoptosis
Maya Emmons-Bell highlights a preprint showing that wounding a planarian shortly after radiation protects stem cells from death, which is important for regenerative growth. This work provides important insight into the complex reactions that occur upon tissue injury.
Catch up with recent preLights selected for the translational biology community.