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  Open access

September, 2019; 12 (9)

FIRST PERSON

  • Open Access
    First person – Karishma Chhabria
    Disease Models & Mechanisms 2019 12: dmm042085 doi: 10.1242/dmm.042085 Published 25 September 2019
  • Open Access
    First person – Eleftheria Pervolaraki
    Disease Models & Mechanisms 2019 12: dmm042408 doi: 10.1242/dmm.042408 Published 24 September 2019
  • Open Access
    First person – Tamio Furuse and Hiroshi Mizuma
    Disease Models & Mechanisms 2019 12: dmm042127 doi: 10.1242/dmm.042127 Published 12 September 2019
  • Open Access
    First person – Katja Graf and Antonia Last
    Disease Models & Mechanisms 2019 12: dmm041970 doi: 10.1242/dmm.041970 Published 12 September 2019
  • Open Access
    First person – Monika J. Tomecka
    Disease Models & Mechanisms 2019 12: dmm041848 doi: 10.1242/dmm.041848 Published 3 September 2019

AT A GLANCE

  • Open Access
    Modeling hematopoietic disorders in zebrafish
    Martina Konantz, Christoph Schürch, Pauline Hanns, Joëlle S. Müller, Loïc Sauteur, Claudia Lengerke
    Disease Models & Mechanisms 2019 12: dmm040360 doi: 10.1242/dmm.040360 Published 6 September 2019

    Summary: This At A Glance article and poster summarize the last 20 years of research in zebrafish models for hematopoietic disorders, highlighting how these models were created and are being applied for translational research.

REVIEW

  • Open Access
    Experimental models and tools to tackle glioblastoma
    Faye L. Robertson, Maria-Angeles Marqués-Torrejón, Gillian M. Morrison, Steven M. Pollard
    Disease Models & Mechanisms 2019 12: dmm040386 doi: 10.1242/dmm.040386 Published 6 September 2019

    Summary: This Review discusses preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems.

RESEARCH ARTICLES

  • Open Access
    Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish
    Karishma Chhabria, Avgoustinos Vouros, Caroline Gray, Ryan B. MacDonald, Zhen Jiang, Robert Neil Wilkinson, Karen Plant, Eleni Vasilaki, Clare Howarth, Timothy J. A. Chico
    Disease Models & Mechanisms 2019 12: dmm039867 doi: 10.1242/dmm.039867 Published 25 September 2019

    Summary: Diabetes is associated with vascular and neurological impairments. The authors show that an NO donor ameliorates the glucose-exposure-induced dysfunction in the tectal neurovascular unit and whole-organism behaviour.

  • Open Access
    Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours
    Eleftheria Pervolaraki, Stephen P. Hall, Denise Foresteire, Takashi Saito, Takaomi C. Saido, Miles A. Whittington, Colin Lever, James Dachtler
    Disease Models & Mechanisms 2019 12: dmm040550 doi: 10.1242/dmm.040550 Published 24 September 2019

    Summary: Aβ overexpression in a second-generation Alzheimer's disease model results in alterations in anxiety-type behaviours, as well as gamma oscillations, neural organisation and Grin2b expression in the prefrontal cortex.

  • Open Access
    Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia
    Jie Gao, Michael Van Meter, Susana Hernandez Lopez, Guoying Chen, Ying Huang, Shumei Ren, Qi Zhao, Jose Rojas, Cagan Gurer, Gavin Thurston, Frank Kuhnert
    Disease Models & Mechanisms 2019 12: dmm040931 doi: 10.1242/dmm.040931 Published 16 September 2019

    Summary: Adapting a spontaneous, genetically heterogenous T-ALL model to preclinical testing demonstrated that response to therapeutic anti-Notch1 antibodies was determined by Notch1 mutational status and that PD-1 immune checkpoint blockade alone lacked anti-tumor activity.

  • Open Access
    A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain
    Tamio Furuse, Hiroshi Mizuma, Yuuki Hirose, Tomoko Kushida, Ikuko Yamada, Ikuo Miura, Hiroshi Masuya, Hiromasa Funato, Masashi Yanagisawa, Hirotaka Onoe, Shigeharu Wakana
    Disease Models & Mechanisms 2019 12: dmm038828 doi: 10.1242/dmm.038828 Published 12 September 2019

    Summary: New phenotypes are revealed by a GLUT1 deficiency mutant mouse model carrying a missense mutation in Glut1.

  • Open Access
    Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model
    Katja Graf, Antonia Last, Rena Gratz, Stefanie Allert, Susanne Linde, Martin Westermann, Marko Gröger, Alexander S. Mosig, Mark S. Gresnigt, Bernhard Hube
    Disease Models & Mechanisms 2019 12: dmm039719 doi: 10.1242/dmm.039719 Published 12 September 2019

    Editor's choice: Using antagonistic lactobacilli, C. albicans pathogenicity was reduced to a minimum in an in vitro gut model consisting of enterocytes and goblet cells.

  • Open Access
    Clinical pathologies of bone fracture modelled in zebrafish
    Monika J. Tomecka, Lalith P. Ethiraj, Luis M. Sánchez, Henry H. Roehl, Tom J. Carney
    Disease Models & Mechanisms 2019 12: dmm037630 doi: 10.1242/dmm.037630 Published 3 September 2019

    Summary: The effect of osteogenesis imperfecta, bisphosphonate treatment and bacterial infection on phases of bone fracture repair are determined using a zebrafish fracture model.

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    The latest from the preLights community – September 2019
    Disease Models & Mechanisms 2019 12: p0901
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Disease Models & Mechanisms: 12 (9)
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  • Open Access

    Neural crest-specific deletion of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction, and disordered breathing modelling Obstructive Sleep Apnea

    Pranidhi Baddam, Vivian Biancardi, Daniela M. Roth, Farah Eaton, Claudine Thereza-Bussolaro, Rupasri Mandal, David S. Wishart, Amy Barr, Joanna MacLean, Carlos Flores-Mir, Silvia Pagliardini, Daniel Graf
    PDF
  • Open Access

    Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

    F. W. Riemslagh, E. C. van der Toorn, R. F. M. Verhagen, A. Maas, L. W. J. Bosman, R. K. Hukema, R. Willemsen
    PDF
  • Open Access

    A muscle growth promoting treatment based on the attenuation of activin/myostatin signalling in young mice results in long-term testicular abnormalities

    Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
    PDF
  • Open Access

    TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

    Rachel Atkinson, Jacqueline Leung, James Bender, Matthew Kirkcaldie, James Vickers, Anna King
    PDF
  • Open Access

    Interpreting the pathogenicity of Joubert Syndrome missense variants in Caenorhabditis elegans

    Karen I. Lange, Sofia Tsiropoulou, Katarzyna Kucharska, Oliver E. Blacque
    PDF
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Interview – Kim Landry-Truchon and Nicolas Houde

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