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RESEARCH ARTICLE
Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
Simone Renner, Ana Sofia Martins, Elisabeth Streckel, Christina Braun-Reichhart, Mattias Backman, Cornelia Prehn, Nikolai Klymiuk, Andrea Bähr, Andreas Blutke, Christina Landbrecht-Schessl, Annegret Wünsch, Barbara Kessler, Mayuko Kurome, Arne Hinrichs, Sietse-Jan Koopmans, Stefan Krebs, Elisabeth Kemter, Birgit Rathkolb, Hiroshi Nagashima, Helmut Blum, Mathias Ritzmann, Rüdiger Wanke, Bernhard Aigner, Jerzy Adamski, Martin Hrabě de Angelis, Eckhard Wolf
Disease Models & Mechanisms 2019 12: dmm039156 doi: 10.1242/dmm.039156 Published 12 August 2019
Simone Renner
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, GermanyGerman Center for Diabetes Research (DZD), 85764 Neuherberg, Germany
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  • ORCID record for Simone Renner
  • For correspondence: simone.renner@lmu.de
Ana Sofia Martins
MWM Biomodels, 84184 Tiefenbach, Germany
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Elisabeth Streckel
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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Christina Braun-Reichhart
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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Mattias Backman
Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
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Cornelia Prehn
Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, 85764 Neuherberg, Germany
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  • ORCID record for Cornelia Prehn
Nikolai Klymiuk
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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  • ORCID record for Nikolai Klymiuk
Andrea Bähr
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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Andreas Blutke
Research Unit Analytical Pathology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
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  • ORCID record for Andreas Blutke
Christina Landbrecht-Schessl
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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  • ORCID record for Christina Landbrecht-Schessl
Annegret Wünsch
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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Barbara Kessler
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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Mayuko Kurome
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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  • ORCID record for Mayuko Kurome
Arne Hinrichs
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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Sietse-Jan Koopmans
Wageningen UR Livestock Research, de Elst 1 and CARUS Animal Facilities, Wageningen University, 6708 WD Wageningen, The Netherlands
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Stefan Krebs
Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
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  • ORCID record for Stefan Krebs
Elisabeth Kemter
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, GermanyGerman Center for Diabetes Research (DZD), 85764 Neuherberg, Germany
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  • ORCID record for Elisabeth Kemter
Birgit Rathkolb
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, GermanyGerman Center for Diabetes Research (DZD), 85764 Neuherberg, GermanyGerman Mouse Clinic (GMC), Helmholtz Zentrum München, 85764 Neuherberg, Germany
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  • ORCID record for Birgit Rathkolb
Hiroshi Nagashima
Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan
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  • ORCID record for Hiroshi Nagashima
Helmut Blum
Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
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Mathias Ritzmann
Clinic for Swine, Center for Clinical Veterinary Medicine, LMU Munich, 85764 Oberschleißheim, Germany
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  • ORCID record for Mathias Ritzmann
Rüdiger Wanke
Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany
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Bernhard Aigner
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, Germany
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Jerzy Adamski
Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, 85764 Neuherberg, GermanyDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596 SingaporeChair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, 85764 Neuherberg, Germany
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  • ORCID record for Jerzy Adamski
Martin Hrabě de Angelis
German Center for Diabetes Research (DZD), 85764 Neuherberg, GermanyGerman Mouse Clinic (GMC), Helmholtz Zentrum München, 85764 Neuherberg, GermanyChair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, 85764 Neuherberg, GermanyInstitute of Experimental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany
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  • ORCID record for Martin Hrabě de Angelis
Eckhard Wolf
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, 81377 Munich, GermanyGerman Center for Diabetes Research (DZD), 85764 Neuherberg, GermanyLaboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
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  • ORCID record for Eckhard Wolf
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Keywords

  • Maternal diabetes
  • Pig
  • Transgenic
  • Developmental programming
  • Metabolomics

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RESEARCH ARTICLE
Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
Simone Renner, Ana Sofia Martins, Elisabeth Streckel, Christina Braun-Reichhart, Mattias Backman, Cornelia Prehn, Nikolai Klymiuk, Andrea Bähr, Andreas Blutke, Christina Landbrecht-Schessl, Annegret Wünsch, Barbara Kessler, Mayuko Kurome, Arne Hinrichs, Sietse-Jan Koopmans, Stefan Krebs, Elisabeth Kemter, Birgit Rathkolb, Hiroshi Nagashima, Helmut Blum, Mathias Ritzmann, Rüdiger Wanke, Bernhard Aigner, Jerzy Adamski, Martin Hrabě de Angelis, Eckhard Wolf
Disease Models & Mechanisms 2019 12: dmm039156 doi: 10.1242/dmm.039156 Published 12 August 2019
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RESEARCH ARTICLE
Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
Simone Renner, Ana Sofia Martins, Elisabeth Streckel, Christina Braun-Reichhart, Mattias Backman, Cornelia Prehn, Nikolai Klymiuk, Andrea Bähr, Andreas Blutke, Christina Landbrecht-Schessl, Annegret Wünsch, Barbara Kessler, Mayuko Kurome, Arne Hinrichs, Sietse-Jan Koopmans, Stefan Krebs, Elisabeth Kemter, Birgit Rathkolb, Hiroshi Nagashima, Helmut Blum, Mathias Ritzmann, Rüdiger Wanke, Bernhard Aigner, Jerzy Adamski, Martin Hrabě de Angelis, Eckhard Wolf
Disease Models & Mechanisms 2019 12: dmm039156 doi: 10.1242/dmm.039156 Published 12 August 2019

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