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  Open access

March, 2019; 12 (3)

EDITORIALS

  • Open Access
    DMM Prize 2018 winner: Wenqing Zhou
    Monica J. Justice (Editor-in-Chief)
    Disease Models & Mechanisms 2019 12: dmm039586 doi: 10.1242/dmm.039586 Published 26 March 2019
  • Open Access
    Spotlight on zebrafish: the next wave of translational research
    E. Elizabeth Patton, David M. Tobin
    Disease Models & Mechanisms 2019 12: dmm039370 doi: 10.1242/dmm.039370 Published 7 March 2019

    Summary: Zebrafish are a highly versatile and relevant organism for human disease modelling. This Editorial highlights the recent zebrafish research published in DMM.

A MODEL FOR LIFE

  • Open Access
    Of oncogenes and open science: an interview with Harold Varmus
    Harold Varmus
    Disease Models & Mechanisms 2019 12: dmm038919 doi: 10.1242/dmm.038919 Published 1 March 2019

FIRST PERSON

  • Open Access
    First person – Emily Jones, Zoe Matthews and Lejla Gul
    Disease Models & Mechanisms 2019 12: dmm039511 doi: 10.1242/dmm.039511 Published 18 March 2019
  • Open Access
    First person – Laura Kuil and Nynke Oosterhof
    Disease Models & Mechanisms 2019 12: dmm039420 doi: 10.1242/dmm.039420 Published 8 March 2019
  • Open Access
    First person – Danny Legge
    Disease Models & Mechanisms 2019 12: dmm039412 doi: 10.1242/dmm.039412 Published 7 March 2019

REVIEW

  • Open Access
    Cardiac phenotype in mouse models of systemic autoimmunity
    Chandan Sanghera, Lok Man Wong, Mona Panahi, Amalia Sintou, Muneer Hasham, Susanne Sattler
    Disease Models & Mechanisms 2019 12: dmm036947 doi: 10.1242/dmm.036947 Published 8 March 2019

    Summary: Cardiac complications are common in systemic autoimmunity, and mouse models are essential for mechanistic and therapeutic studies. Here, the authors present a decision framework to facilitate model choice for selected cardiac phenotypes in systemic autoimmunity.

RESEARCH ARTICLES

  • Open Access
    Establishment of a zebrafish hematological disease model induced by 1,4-benzoquinone
    Ao Zhang, Mei Wu, Junliang Tan, Ning Yu, Mengchang Xu, Xutong Yu, Wei Liu, Yiyue Zhang
    Disease Models & Mechanisms 2019 12: dmm037903 doi: 10.1242/dmm.037903 Published 28 March 2019

    Summary: Acute exposure to 1,4-benzoquinone leads to lineage-specific hematotoxicity in zebrafish from embryonic stages to adulthood, resembling benzene-induced cytopenia and myeloid dysplasia in humans.

  • Open Access
    Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the Drosophila mushroom body
    Melissa C. Chubak, Kevin C. J. Nixon, Max H. Stone, Nicholas Raun, Shelby L. Rice, Mohammed Sarikahya, Spencer G. Jones, Taylor A. Lyons, Taryn E. Jakub, Roslyn L. M. Mainland, Maria J. Knip, Tara N. Edwards, Jamie M. Kramer
    Disease Models & Mechanisms 2019 12: dmm037325 doi: 10.1242/dmm.037325 Published 25 March 2019

    Summary: The SWI/SNF chromatin remodelling complex is the most over-represented protein complex in the intellectual disability. Different components of this complex have distinct roles in development and function of memory-forming neurons in the Drosophila mushroom body.

  • Open Access
    Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model
    Jorge del-Pozo, Neil MacIntyre, Ali Azar, James Glover, Elspeth Milne, Michael Cheeseman
    Disease Models & Mechanisms 2019 12: dmm038315 doi: 10.1242/dmm.038315 Published 21 March 2019

    Summary: FBXO11 is a candidate disease gene for otitis media in humans and the authors report that a bulla cavitation defect initiates otitis media in the Fbxo11Jf/+ mouse model.

  • Open Access
    Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy
    Emily J. Jones, Zoe J. Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina Divekar, Jasmine Buck, Tomasz Wrzesinski, Matthew Jefferson, Stuart D. Armstrong, Lindsay J. Hall, Alastair J. M. Watson, Simon R. Carding, Wilfried Haerty, Federica Di Palma, Ulrike Mayer, Penny P. Powell, Isabelle Hautefort, Tom Wileman, Tamas Korcsmaros
    Disease Models & Mechanisms 2019 12: dmm037069 doi: 10.1242/dmm.037069 Published 18 March 2019

    Editor's choice: Using an integrative approach encompassing intestinal organoid culture, proteomics, transcriptomics and protein-protein interaction networks, we list Paneth cell functions dependent on autophagy.

  • Open Access
    The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria
    Laura Martorano, Margherita Peron, Claudio Laquatra, Elisa Lidron, Nicola Facchinello, Giacomo Meneghetti, Natascia Tiso, Andrea Rasola, Daniele Ghezzi, Francesco Argenton
    Disease Models & Mechanisms 2019 12: dmm037226 doi: 10.1242/dmm.037226 Published 14 March 2019

    Summary: The zebrafish mpv17−/− mutant shows a severe mitochondrial phenotype with ultrastructural alterations and oxidative phosphorylation impairment. The pyrimidine precursor orotic acid ameliorates mpv17−/− phenotype and increases mitochondrial DNA content, linking the loss of Mpv17 to pyrimidine de novo synthesis.

  • Open Access
    Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain
    Laura E. Kuil, Nynke Oosterhof, Samuël N. Geurts, Herma C. van der Linde, Erik Meijering, Tjakko J. van Ham
    Disease Models & Mechanisms 2019 12: dmm037762 doi: 10.1242/dmm.037762 Published 8 March 2019

    Summary: Using a new reverse genetic screening method for zebrafish microglia development, involving automated image analysis, we identified that il34 facilitates yolk sac macrophage distribution to target organs, including the brain.

  • Open Access
    BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells
    Danny N. Legge, Alex P. Shephard, Tracey J. Collard, Alexander Greenhough, Adam C. Chambers, Richard W. Clarkson, Christos Paraskeva, Ann C. Williams
    Disease Models & Mechanisms 2019 12: dmm037697 doi: 10.1242/dmm.037697 Published 4 March 2019

    Summary: BCL-3 acts as a co-activator of β-catenin/TCF-mediated transcriptional activity, driving a stem-cell-like phenotype in colorectal cancer cells, with implications for tumour cell plasticity and therapeutic resistance.

  • Open Access
    Early and late endothelial response in breast cancer metastasis in mice: simultaneous quantification of endothelial biomarkers using a mass spectrometry-based method
    Joanna Suraj, Anna Kurpińska, Agnieszka Zakrzewska, Magdalena Sternak, Marta Stojak, Agnieszka Jasztal, Maria Walczak, Stefan Chlopicki
    Disease Models & Mechanisms 2019 12: dmm036269 doi: 10.1242/dmm.036269 Published 1 March 2019

    Summary: A microLC/MS-MRM-based approach for simultaneous determination of endothelium-related biomarkers identified glycocalyx disruption, endothelial inflammation and increased endothelial permeability as important events in early pulmonary metastasis in a murine model of breast cancer metastasis.

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    The latest from the preLights community – March 2019
    Disease Models & Mechanisms 2019 12: p0301
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  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
  • Open Access

    Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

    Paco López-Cuevas, Luke Deane, Yushi Yang, Chrissy L Hammond, Erika Kague
    PDF
  • Open Access

    Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

    Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
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DMM and COVID-19

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Monica Justice bids farewell to DMM

In her farewell Editorial, outgoing Editor-in-Chief Monica Justice reminds us of the past half-decade of growth and of DMM's commitment to support the disease modelling community, concluding, “The knowledge and experience I gained during my time as Senior Editor and EiC at DMM is invaluable: working within a not-for-profit community publishing environment is a joy.”


3D imaging of beta cell mass in diabetic mouse models

In their inducible mouse model of diabetes, Roostalu et al. demonstrate how quantitative light-sheet imaging can capture changes in individual islets to help pharmacological research in diabetes.

Visit our YouTube channel to watch more videos from DMM, our sister journals and the Company.


Modelling Joubert syndrome patient-derived mutations in C. elegans

In this issue’s Editor’s choice, Karen Lange and colleagues used C. elegans to model and characterise two patient-derived mutations that cause the ciliopathy Joubert syndrome.


Interview – Karen Lange

First author of our current Editor’s choice, Karen Lange takes us behind the scenes of the paper, and shares her thoughts on how the lack of both time and job security will impact her research.

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