EDITORIALS
- Spotlight on zebrafish: the next wave of translational research
Summary: Zebrafish are a highly versatile and relevant organism for human disease modelling. This Editorial highlights the recent zebrafish research published in DMM.
A MODEL FOR LIFE
FIRST PERSON
REVIEW
- Cardiac phenotype in mouse models of systemic autoimmunity
Summary: Cardiac complications are common in systemic autoimmunity, and mouse models are essential for mechanistic and therapeutic studies. Here, the authors present a decision framework to facilitate model choice for selected cardiac phenotypes in systemic autoimmunity.
RESEARCH ARTICLES
- Establishment of a zebrafish hematological disease model induced by 1,4-benzoquinone
Summary: Acute exposure to 1,4-benzoquinone leads to lineage-specific hematotoxicity in zebrafish from embryonic stages to adulthood, resembling benzene-induced cytopenia and myeloid dysplasia in humans.
- Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the Drosophila mushroom body
Summary: The SWI/SNF chromatin remodelling complex is the most over-represented protein complex in the intellectual disability. Different components of this complex have distinct roles in development and function of memory-forming neurons in the Drosophila mushroom body.
- Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model
Summary: FBXO11 is a candidate disease gene for otitis media in humans and the authors report that a bulla cavitation defect initiates otitis media in the Fbxo11Jf/+ mouse model.
- Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy
Editor's choice: Using an integrative approach encompassing intestinal organoid culture, proteomics, transcriptomics and protein-protein interaction networks, we list Paneth cell functions dependent on autophagy.
- The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria
Summary: The zebrafish mpv17−/− mutant shows a severe mitochondrial phenotype with ultrastructural alterations and oxidative phosphorylation impairment. The pyrimidine precursor orotic acid ameliorates mpv17−/− phenotype and increases mitochondrial DNA content, linking the loss of Mpv17 to pyrimidine de novo synthesis.
- Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain
Summary: Using a new reverse genetic screening method for zebrafish microglia development, involving automated image analysis, we identified that il34 facilitates yolk sac macrophage distribution to target organs, including the brain.
- BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells
Summary: BCL-3 acts as a co-activator of β-catenin/TCF-mediated transcriptional activity, driving a stem-cell-like phenotype in colorectal cancer cells, with implications for tumour cell plasticity and therapeutic resistance.
- Early and late endothelial response in breast cancer metastasis in mice: simultaneous quantification of endothelial biomarkers using a mass spectrometry-based method
Summary: A microLC/MS-MRM-based approach for simultaneous determination of endothelium-related biomarkers identified glycocalyx disruption, endothelial inflammation and increased endothelial permeability as important events in early pulmonary metastasis in a murine model of breast cancer metastasis.
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DMM and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
Alessandro Bailetti is awarded the DMM Outstanding Paper Prize 2019
The annual prize is awarded to the first author of the paper that is judged by the journal’s editors to be the most outstanding contribution to the journal that year. Alessandro Bailetti's winning paper presents results that indicate a possible connection between E(Pc) and the Tip60 complex, and leukemia. Find out more about Alessandro and read the winning paper.
Find DMM online
We may not be meeting you in person this year, but we’re always here to chat about DMM and The Company of Biologists. Join the conversation over on Twitter, email us or catch Scientific Editor Julija Hmeljak at these upcoming virtual meetings:
MRC Human Genetics Unit (Virtual) Symposium: Aberrant Cell State Transitions in Human Disease
23-24 September
Genomic Imprinting – from Biology to Disease
28 September – 1 October
ZDMS Virtual webinar series
Throughout September – December
Interview - Mohd. Salman
First author Mohd. Salman studies traumatic brain injury. In an interview, he takes us through his latest research in DMM, explaining the potential implications of the findings, and discussing Wistar rats as a model system and life as a early-career researcher.
Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond
DMM invites you to submit original research for a special issue focused on targeting the RAS pathway. The submission deadline is 1 March 2021. Find out more and showcase your breakthrough research in this special collection.
It’s a time of turmoil for young scientists
“My students are my priority – they are on the brink of their careers.”
Dr Jodie Rummer (ARC Centre of Excellence for Coral Reef Studies at James Cook University) talks about the importance of her role as a supervisor in supporting graduate students and post docs financially, intellectually and emotionally during this period of uncertainty.