Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability by Sullivan et al.
Cancer metabolism: what can we learn from analysing metabolites in tumour infiltrating fluid rather than in blood plasma?
Selected by Maria Rafaeva. Read the preLight here
Mechanical Stretch Kills Transformed Cancer Cells by Tijore et al.
Forcefully aiming at cancer cells.
Selected by Vibha Singh. Read the preLight here
A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart by Honkoop et al.
Heart regeneration: Cardiomyocytes need to undergo a metabolic switch in order to re-enter the cell cycle.
Selected by Andreas van Impel. Read the preLight here
A schizophrenia risk gene, NRGN, bidirectionally modulates synaptic plasticity via regulating the neuronal phosphoproteome by Hongik Hwang
Hwang et al. show neurogranin regulates CaM-Ca2+ levels and phosphatase activity in the post-synaptic compartment and influences synaptic plasticity.
Selected by Laura McCormick. Read the preLight here
A conserved MFS orchestrates a subset of O-glycosylation to facilitate macrophage dissemination and tissue invasion by Valoskova et al.
Minerva instructs Drosophila embryonic macrophages to push the boundaries of tissue invasion by initiating a developmentally controlled program of glycosylation.
Selected by Giuliana Clemente. Read the preLight here
Applications of Machine Learning in Decision Analysis for Dose Management for Dofetilide by Levy et al.
AND
Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer
by Schneider et al.
Where dosing dreams are born: Developments in drug toxicity modelling and reinforcement learning in optimising drug dosing regimens.
Selected by Zhang-He Goh. Read the preLight here
Bacteriophage resistance alters antibiotic mediated intestinal expansion of enterococci by Chatterjee et al.
Resistance is futile: Phage therapy used with antibiotics to combat enterococci in a dysbiotic microbiota.
Selected by Yasmin Lau. Read the preLight here
Tracking the popularity and outcomes of all bioRxiv preprints by Abdill & Blekhman
What makes preprints popular? preLighters respond to a meta-analysis of bioRxiv preprints.
Read the preLight here
- © 2019. Published by The Company of Biologists Ltd
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DMM and COVID-19
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Alessandro Bailetti is awarded the DMM Outstanding Paper Prize 2019
The annual prize is awarded to the first author of the paper that is judged by the journal’s editors to be the most outstanding contribution to the journal that year. Alessandro Bailetti's winning paper presents results that indicate a possible connection between E(Pc) and the Tip60 complex, and leukemia. Find out more about Alessandro and read the winning paper.
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First author Mohd. Salman studies traumatic brain injury. In an interview, he takes us through his latest research in DMM, explaining the potential implications of the findings, and discussing Wistar rats as a model system and life as a early-career researcher.
Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond
DMM invites you to submit original research for a special issue focused on targeting the RAS pathway. The submission deadline is 1 March 2021. Find out more and showcase your breakthrough research in this special collection.
It’s a time of turmoil for young scientists
“My students are my priority – they are on the brink of their careers.”
Dr Jodie Rummer (ARC Centre of Excellence for Coral Reef Studies at James Cook University) talks about the importance of her role as a supervisor in supporting graduate students and post docs financially, intellectually and emotionally during this period of uncertainty.