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Preprint Highlights
The latest from the preLights community – February 2019
Disease Models & Mechanisms 2019 12: p0201
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Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability by Sullivan et al.

Cancer metabolism: what can we learn from analysing metabolites in tumour infiltrating fluid rather than in blood plasma?

Selected by Maria Rafaeva. Read the preLight here

 

Mechanical Stretch Kills Transformed Cancer Cells by Tijore et al.

Forcefully aiming at cancer cells.

Selected by Vibha Singh. Read the preLight here

 

A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart by Honkoop et al.

Heart regeneration: Cardiomyocytes need to undergo a metabolic switch in order to re-enter the cell cycle.

Selected by Andreas van Impel. Read the preLight here

 

A schizophrenia risk gene, NRGN, bidirectionally modulates synaptic plasticity via regulating the neuronal phosphoproteome by Hongik Hwang

Hwang et al. show neurogranin regulates CaM-Ca2+ levels and phosphatase activity in the post-synaptic compartment and influences synaptic plasticity.

Selected by Laura McCormick. Read the preLight here

 

A conserved MFS orchestrates a subset of O-glycosylation to facilitate macrophage dissemination and tissue invasion by Valoskova et al.

Minerva instructs Drosophila embryonic macrophages to push the boundaries of tissue invasion by initiating a developmentally controlled program of glycosylation.

Selected by Giuliana Clemente. Read the preLight here

 

Applications of Machine Learning in Decision Analysis for Dose Management for Dofetilide by Levy et al.

AND

Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer

by Schneider et al.

Where dosing dreams are born: Developments in drug toxicity modelling and reinforcement learning in optimising drug dosing regimens.

Selected by Zhang-He Goh. Read the preLight here

 

Bacteriophage resistance alters antibiotic mediated intestinal expansion of enterococci by Chatterjee et al.

Resistance is futile: Phage therapy used with antibiotics to combat enterococci in a dysbiotic microbiota.

Selected by Yasmin Lau. Read the preLight here

 

Tracking the popularity and outcomes of all bioRxiv preprints by Abdill & Blekhman

What makes preprints popular? preLighters respond to a meta-analysis of bioRxiv preprints.

Read the preLight here

  • © 2019. Published by The Company of Biologists Ltd
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DMM and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.


Monica Justice bids farewell to DMM

In her farewell Editorial, outgoing Editor-in-Chief Monica Justice reminds us of the past half-decade of growth and of DMM's commitment to support the disease modelling community, concluding, “The knowledge and experience I gained during my time as Senior Editor and EiC at DMM is invaluable: working within a not-for-profit community publishing environment is a joy.”


3D imaging of beta cell mass in diabetic mouse models

In their inducible mouse model of diabetes, Roostalu et al. demonstrate how quantitative light-sheet imaging can capture changes in individual islets to help pharmacological research in diabetes.

Visit our YouTube channel to watch more videos from DMM, our sister journals and the Company.


Modelling Joubert syndrome patient-derived mutations in C. elegans

In this issue’s Editor’s choice, Karen Lange and colleagues used C. elegans to model and characterise two patient-derived mutations that cause the ciliopathy Joubert syndrome.


Interview – Karen Lange

First author of our current Editor’s choice, Karen Lange takes us behind the scenes of the paper, and shares her thoughts on how the lack of both time and job security will impact her research.

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