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RESEARCH ARTICLE
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects
Thomas Delerue, Déborah Tribouillard-Tanvier, Marlène Daloyau, Farnoosh Khosrobakhsh, Laurent Jean Emorine, Gaëlle Friocourt, Pascale Belenguer, Marc Blondel, Laetitia Arnauné-Pelloquin
Disease Models & Mechanisms 2019 12: dmm036558 doi: 10.1242/dmm.036558 Published 7 February 2019
Thomas Delerue
1Research Center on Animal Cognition (CRCA) and Center of Developmental Biology (CBD), Center for Integrative Biology (CBI), Toulouse University, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France
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Déborah Tribouillard-Tanvier
2Institut National de la Santé et de la Recherche Médicale UMR1078, Université de Bretagne Occidentale, Etablissement Français du Sang Bretagne, CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, 29200 Brest, France
3Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, Université de Bordeaux, 1 rue Camille Saint-Saëns, 33077 Bordeaux, France
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  • ORCID record for Déborah Tribouillard-Tanvier
Marlène Daloyau
1Research Center on Animal Cognition (CRCA) and Center of Developmental Biology (CBD), Center for Integrative Biology (CBI), Toulouse University, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France
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Farnoosh Khosrobakhsh
1Research Center on Animal Cognition (CRCA) and Center of Developmental Biology (CBD), Center for Integrative Biology (CBI), Toulouse University, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France
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Laurent Jean Emorine
1Research Center on Animal Cognition (CRCA) and Center of Developmental Biology (CBD), Center for Integrative Biology (CBI), Toulouse University, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France
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Gaëlle Friocourt
2Institut National de la Santé et de la Recherche Médicale UMR1078, Université de Bretagne Occidentale, Etablissement Français du Sang Bretagne, CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, 29200 Brest, France
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Pascale Belenguer
1Research Center on Animal Cognition (CRCA) and Center of Developmental Biology (CBD), Center for Integrative Biology (CBI), Toulouse University, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France
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  • ORCID record for Pascale Belenguer
  • For correspondence: pascale.belenguer@univ-tlse3.fr
Marc Blondel
2Institut National de la Santé et de la Recherche Médicale UMR1078, Université de Bretagne Occidentale, Etablissement Français du Sang Bretagne, CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, 29200 Brest, France
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Laetitia Arnauné-Pelloquin
1Research Center on Animal Cognition (CRCA) and Center of Developmental Biology (CBD), Center for Integrative Biology (CBI), Toulouse University, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France
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Keywords

  • Mitochondrial fusion
  • Mitochondrial DNA
  • Hexestrol
  • Clomifene
  • Yeast
  • OPA1

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RESEARCH ARTICLE
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects
Thomas Delerue, Déborah Tribouillard-Tanvier, Marlène Daloyau, Farnoosh Khosrobakhsh, Laurent Jean Emorine, Gaëlle Friocourt, Pascale Belenguer, Marc Blondel, Laetitia Arnauné-Pelloquin
Disease Models & Mechanisms 2019 12: dmm036558 doi: 10.1242/dmm.036558 Published 7 February 2019
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RESEARCH ARTICLE
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects
Thomas Delerue, Déborah Tribouillard-Tanvier, Marlène Daloyau, Farnoosh Khosrobakhsh, Laurent Jean Emorine, Gaëlle Friocourt, Pascale Belenguer, Marc Blondel, Laetitia Arnauné-Pelloquin
Disease Models & Mechanisms 2019 12: dmm036558 doi: 10.1242/dmm.036558 Published 7 February 2019

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