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RESEARCH ARTICLE
Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis
Soo-Hyun Kim, Richard P. Redvers, Lap Hing Chi, Xiawei Ling, Andrew J. Lucke, Robert C. Reid, David P. Fairlie, Ana Carolina Baptista Moreno Martin, Robin L. Anderson, Delphine Denoyer, Normand Pouliot
Disease Models & Mechanisms 2018 11: DMM034850 doi: 10.1242/dmm.034850 Published 6 July 2018
Soo-Hyun Kim
1Metastasis Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia
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  • ORCID record for Soo-Hyun Kim
Richard P. Redvers
2Metastasis Research Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia
3School of Cancer Medicine, La Trobe University Bundoora, VIC, 3086, Australia
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Lap Hing Chi
2Metastasis Research Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia
3School of Cancer Medicine, La Trobe University Bundoora, VIC, 3086, Australia
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Xiawei Ling
1Metastasis Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia
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Andrew J. Lucke
4Division of Chemistry and Structural Biology, ARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Qld, 4072, Australia
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Robert C. Reid
4Division of Chemistry and Structural Biology, ARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Qld, 4072, Australia
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David P. Fairlie
4Division of Chemistry and Structural Biology, ARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Qld, 4072, Australia
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Ana Carolina Baptista Moreno Martin
5Department of Gerontology, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil
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  • ORCID record for Ana Carolina Baptista Moreno Martin
Robin L. Anderson
2Metastasis Research Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia
3School of Cancer Medicine, La Trobe University Bundoora, VIC, 3086, Australia
6Department of Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia
7Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia
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Delphine Denoyer
8Matrix Microenvironment & Metastasis Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia
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Normand Pouliot
3School of Cancer Medicine, La Trobe University Bundoora, VIC, 3086, Australia
6Department of Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia
7Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia
8Matrix Microenvironment & Metastasis Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia
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  • For correspondence: normand.pouliot@onjcri.org.au
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Article Information

vol. 11 no. 7, DMM034850

DOI 
https://doi.org/10.1242/dmm.034850
PubMed 
29784888

Published By 
The Company of Biologists Ltd
Print ISSN 
1754-8403
Online ISSN 
1754-8411
History 
  • Received April 6, 2018
  • Accepted May 15, 2018
  • Published online July 6, 2018.
Posted online 
May 21, 2018
Copyright & Usage 
© 2018. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Article Versions

  • Previous version (May 21, 2018 - 00:34).
  • You are viewing the most recent version of this article.

Author Information

  1. Soo-Hyun Kim1,*,‡,
  2. Richard P. Redvers2,3,‡,
  3. Lap Hing Chi2,3,
  4. Xiawei Ling1,
  5. Andrew J. Lucke4,
  6. Robert C. Reid4,
  7. David P. Fairlie4,
  8. Ana Carolina Baptista Moreno Martin5,
  9. Robin L. Anderson2,3,6,7,
  10. Delphine Denoyer8,§ and
  11. Normand Pouliot3,6,7,8,§,¶
  1. 1Metastasis Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia
  2. 2Metastasis Research Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia
  3. 3School of Cancer Medicine, La Trobe University Bundoora, VIC, 3086, Australia
  4. 4Division of Chemistry and Structural Biology, ARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Qld, 4072, Australia
  5. 5Department of Gerontology, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil
  6. 6Department of Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia
  7. 7Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia
  8. 8Matrix Microenvironment & Metastasis Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia
  1. ↵¶Author for correspondence (normand.pouliot{at}onjcri.org.au)
    • ↵* Present address: Oncology Research Team, Cancer Research Center, SK Biopharmaceuticals, 221 Pangyoyeok-ro, Seongnam-si, Gyeonggi-do, 13494, Republic of Korea.

    • ↵‡ These authors contributed equally to this work

    • ↵§ Co-senior authors

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    Keywords

    • 4T1Br4
    • Breast cancer
    • Brain metastasis
    • Syngeneic mouse model
    • Histone deacetylase inhibitor

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    RESEARCH ARTICLE
    Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis
    Soo-Hyun Kim, Richard P. Redvers, Lap Hing Chi, Xiawei Ling, Andrew J. Lucke, Robert C. Reid, David P. Fairlie, Ana Carolina Baptista Moreno Martin, Robin L. Anderson, Delphine Denoyer, Normand Pouliot
    Disease Models & Mechanisms 2018 11: DMM034850 doi: 10.1242/dmm.034850 Published 6 July 2018
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    RESEARCH ARTICLE
    Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis
    Soo-Hyun Kim, Richard P. Redvers, Lap Hing Chi, Xiawei Ling, Andrew J. Lucke, Robert C. Reid, David P. Fairlie, Ana Carolina Baptista Moreno Martin, Robin L. Anderson, Delphine Denoyer, Normand Pouliot
    Disease Models & Mechanisms 2018 11: DMM034850 doi: 10.1242/dmm.034850 Published 6 July 2018

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