EDITORIAL
- Tracking progress: an update on animal models for Duchenne muscular dystrophy
Summary: With the development of a novel rabbit model of Duchenne muscular dystrophy (dmm032201), this Editorial reflects on the current animal models of this disease, their promise, prospects and pitfalls.
REVIEWS
- Using Drosophila to study mechanisms of hereditary hearing loss
Summary: This Review discusses the similarities and differences between hearing in mammals and the fruit fly Drosophila, and describes how recent technological developments allow Drosophila to be used as a model to understand the function of human deafness genes.
- Collagen VI in healthy and diseased nervous system
Summary: Although collagen VI was so far known to be mostly involved in skeletal muscle homeostasis, this Review summarizes a number of recent studies that highlight its key role in the peripheral and central nervous systems, pointing at a link with human neurological disorders.
RESEARCH ARTICLES
- RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory
Summary: The authors characterize a rodent model of RNaseT2 deficiency, which offers insight into the susceptibility of the hippocampus to early inflammation caused by lysosome impairment due to loss of RNaseT2 function.
- Adding a temporal dimension to the study of Friedreich's ataxia: the effect of frataxin overexpression in a human cell model
Summary: We have probed the effect of overexpression of the frataxin gene in an inducible cellular model. Our data indicate that the levels of frataxin must be tightly regulated, because any imbalance leads to oxidative stress and toxicity.
- Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart
Summary: Cardiac mesenchymal stem cells respond early to myocardial infarction. Their regenerative capacity is directly upregulated by optimized stimulation of the heart through epicardial erythropoietin delivery.
- Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin
Summary: Caenorhabditis elegans is a valuable model to identify genetic factors influencing the animal response to the widely used chemotherapeutic agent cisplatin.
- Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats
Summary: The present study suggests that Cacna1c plays a prominent role in regulating socio-affective communication in rats with relevance for neuropsychiatric disorders.
- Subchondral drilling for articular cartilage repair: a systematic review of translational research
Summary: Cartilage defects initiate osteoarthritis. This is the first systematic review of translational evidence of cartilage defects in animal models treated by drilling, enhancing translation from basic science to clinical application.
- A comprehensive study of calcific aortic stenosis: from rabbit to human samples
Summary: Using a rabbit model of calcific aortic stenosis, we have defined a molecular panel of three proteins related to osteoblastic differentiation. Additionally, this panel has been confirmed in human samples.
- Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation
Summary: This study shows that chromatin remodelers that are overexpressed in a zebrafish model of RB1 mutant brain cancer are required for neural progenitor proliferation and survival, providing insight into potential mechanisms that drive tumor growth.
- Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull
Summary: Cranial ossification responds to Fgf8 overexpression in a dose-dependent manner with moderate levels leading to craniosynostosis and higher levels shifting cranial vault ossification to abnormal cartilage formation.
- Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila
Summary: Using a Drosophila model of adrenoleukodystrophy, the authors provide evidence against the current view that an accumulation of lipid metabolic pathway precursors is causative of this neurometabolic disease. Rather, a lack of pathway product is the causative factor and addition of medium-chain fatty acids to the diet prevented the onset of neurodegeneration.
- Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes
Summary: β-cell glucokinase expression is decreased in diet-induced diabetes. β-cell-targeted overexpression of glucokinase improved the diabetic phenotype, suggesting an etiological role of glucokinase downregulation in diet-induced diabetes.
- Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome
Editor's choice: Comparison of corticogenesis, gene expression and behavior in three mouse models of Down syndrome revealed major differences between the models as well as significant limitations in each strain for understanding neurobiological changes in the human phenotype.
- Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy
Summary: Neurotoxic side effects of chemotherapy are poorly understood. Here, the authors optimize a Drosophila model of paclitaxel-induced sensory dysfunction, which is then used to explore the neuroprotective capacity of Nmnat.
- A novel rabbit model of Duchenne muscular dystrophy generated by CRISPR/Cas9
Summary: The DMD KO rabbit engineered by CRISPR genome editing faithfully recapitulates the DMD pathologies, and could be a valuable tool for basic and translational studies to combat this disease.
This issue
Other journals from The Company of Biologists
DMM and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
Alessandro Bailetti is awarded the DMM Outstanding Paper Prize 2019
The annual prize is awarded to the first author of the paper that is judged by the journal’s editors to be the most outstanding contribution to the journal that year. Alessandro Bailetti's winning paper presents results that indicate a possible connection between E(Pc) and the Tip60 complex, and leukemia. Find out more about Alessandro and read the winning paper.
Find DMM online
We may not be meeting you in person this year, but we’re always here to chat about DMM and The Company of Biologists. Join the conversation over on Twitter, email us or catch Scientific Editor Julija Hmeljak at these upcoming virtual meetings:
MRC Human Genetics Unit (Virtual) Symposium: Aberrant Cell State Transitions in Human Disease
23-24 September
Genomic Imprinting – from Biology to Disease
28 September – 1 October
ZDMS Virtual webinar series
Throughout September – December
Interview - Mohd. Salman
First author Mohd. Salman studies traumatic brain injury. In an interview, he takes us through his latest research in DMM, explaining the potential implications of the findings, and discussing Wistar rats as a model system and life as a early-career researcher.
Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond
DMM invites you to submit original research for a special issue focused on targeting the RAS pathway. The submission deadline is 1 March 2021. Find out more and showcase your breakthrough research in this special collection.
It’s a time of turmoil for young scientists
“My students are my priority – they are on the brink of their careers.”
Dr Jodie Rummer (ARC Centre of Excellence for Coral Reef Studies at James Cook University) talks about the importance of her role as a supervisor in supporting graduate students and post docs financially, intellectually and emotionally during this period of uncertainty.