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REVIEW
Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
Jelle J. F. Sleeboom, Hossein Eslami Amirabadi, Poornima Nair, Cecilia M. Sahlgren, Jaap M. J. den Toonder
Disease Models & Mechanisms 2018 11: dmm033100 doi: 10.1242/dmm.033100 Published 16 March 2018
Jelle J. F. Sleeboom
1Microsystems Group, Department of Mechanical Engineering, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
2Soft Tissue Engineering & Mechanobiology, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
3Institute for Complex Molecular Systems, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
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Hossein Eslami Amirabadi
1Microsystems Group, Department of Mechanical Engineering, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
3Institute for Complex Molecular Systems, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
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Poornima Nair
1Microsystems Group, Department of Mechanical Engineering, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
3Institute for Complex Molecular Systems, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
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  • ORCID record for Poornima Nair
Cecilia M. Sahlgren
2Soft Tissue Engineering & Mechanobiology, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
3Institute for Complex Molecular Systems, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
4Turku Centre for Biotechnology, Åbo Akademi University, Domkyrkotorget 3, FI-20500, Turku, Finland
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Jaap M. J. den Toonder
1Microsystems Group, Department of Mechanical Engineering, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
3Institute for Complex Molecular Systems, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
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  • ORCID record for Jaap M. J. den Toonder
  • For correspondence: J.M.J.d.Toonder@tue.nl
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Article Information

vol. 11 no. 3, dmm033100

DOI 
https://doi.org/10.1242/dmm.033100
PubMed 
29555848

Published By 
The Company of Biologists Ltd
Print ISSN 
1754-8403
Online ISSN 
1754-8411
History 
  • Published online March 16, 2018.
Copyright & Usage 
© 2018. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.


Author Information

  1. Jelle J. F. Sleeboom1,2,3,*,
  2. Hossein Eslami Amirabadi1,3,*,
  3. Poornima Nair1,3,
  4. Cecilia M. Sahlgren2,3,4 and
  5. Jaap M. J. den Toonder1,3,‡
  1. 1Microsystems Group, Department of Mechanical Engineering, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
  2. 2Soft Tissue Engineering & Mechanobiology, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
  3. 3Institute for Complex Molecular Systems, Eindhoven University of Technology, Gemini-Zuid, Groene Loper 15, 5612AZ, Eindhoven, The Netherlands
  4. 4Turku Centre for Biotechnology, Åbo Akademi University, Domkyrkotorget 3, FI-20500, Turku, Finland
  1. ↵‡Author for correspondence (J.M.J.d.Toonder{at}tue.nl)
    • ↵* These authors contributed equally to this work

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    Keywords

    • Cancer-on-a-chip
    • Microfluidics
    • Tumor microenvironment
    • Cancer
    • Metastasis

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    REVIEW
    Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
    Jelle J. F. Sleeboom, Hossein Eslami Amirabadi, Poornima Nair, Cecilia M. Sahlgren, Jaap M. J. den Toonder
    Disease Models & Mechanisms 2018 11: dmm033100 doi: 10.1242/dmm.033100 Published 16 March 2018
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    REVIEW
    Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
    Jelle J. F. Sleeboom, Hossein Eslami Amirabadi, Poornima Nair, Cecilia M. Sahlgren, Jaap M. J. den Toonder
    Disease Models & Mechanisms 2018 11: dmm033100 doi: 10.1242/dmm.033100 Published 16 March 2018

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    Article navigation

    • Top
    • Article
      • ABSTRACT
      • Introduction
      • The tumor microenvironment
      • The contributions of cancer-on-a-chip
      • Modeling intrinsic biochemical changes in the tumor
      • Modeling the cellular environment of the tumor
      • Modeling the cancer-cell–ECM interactions
      • Modeling mechanical cues in the tumor
      • The future of cancer-on-a-chip technology
      • Conclusion
      • Acknowledgements
      • Footnotes
      • References
    • Figures & tables
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