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  Open access

June, 2017; 10 (6)

AT A GLANCE

  • Open Access
    Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
    Katharina Timper, Jens C. Brüning
    Disease Models & Mechanisms 2017 10: 679-689; doi: 10.1242/dmm.026609

    Summary: This at a glance article gives an overview of the recent knowledge mainly derived from rodent models regarding the CNS-dependent regulation of energy and glucose homeostasis, and depicts how dysregulation of the involved neuronal networks promotes overnutrition and obesity.

REVIEW

  • Open Access
    Induced pluripotent stem cell models of lysosomal storage disorders
    Daniel K. Borger, Benjamin McMahon, Tamanna Roshan Lal, Jenny Serra-Vinardell, Elma Aflaki, Ellen Sidransky
    Disease Models & Mechanisms 2017 10: 691-704; doi: 10.1242/dmm.029009

    Summary: This Review discusses how induced pluripotent stem cells (iPSCs) provide new opportunities to explore the biology and pathophysiology of lysosomal storage diseases, and how iPSCs have illuminated the role of lysosomes in more common disorders.

RESEARCH ARTICLES

  • Open Access
    SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression
    Liesbeth Zwarts, Veerle Vulsteke, Edgar Buhl, James J. L. Hodge, Patrick Callaerts
    Disease Models & Mechanisms 2017 10: 705-716; doi: 10.1242/dmm.027151

    Editors' choice: A Drosophila model to study the role of PRODH, a schizophrenia-associated gene, in behavioral disorders.

  • Open Access
    Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome
    Lucy M. Hinder, Phillipe D. O'Brien, John M. Hayes, Carey Backus, Andrew P. Solway, Catrina Sims-Robinson, Eva L. Feldman
    Disease Models & Mechanisms 2017 10: 717-725; doi: 10.1242/dmm.028530

    Summary: A mouse model of metabolic syndrome can be used to investigate peripheral nerve damage, enabling the development of mechanism-based therapies for neuropathy.

  • Open Access
    Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling
    Jessica R. White, Huiyu Gong, Brock Pope, Patrick Schlievert, Steven J. McElroy
    Disease Models & Mechanisms 2017 10: 727-736; doi: 10.1242/dmm.028589

    Summary: Paneth cell disruption and bacterial exposure in immature murine intestine induces NEC-like pathology. Importantly, this occurs independently of TLR4 activation, presenting an alternative mechanism for disease development.

  • Open Access
    Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases
    Julia Sellin, Heike Schulze, Marie Paradis, Dominic Gosejacob, Cyrus Papan, Andrej Shevchenko, Olympia Ekaterina Psathaki, Achim Paululat, Melanie Thielisch, Konrad Sandhoff, Michael Hoch
    Disease Models & Mechanisms 2017 10: 737-750; doi: 10.1242/dmm.027953

    Summary: Detailed analysis of lipid accumulation, lysosomal dysfunction and neurodegeneration in a Drosophila sphingolipidosis model, suitable for studying the resulting pathological signaling events.

  • Open Access
    Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis
    Li-Fong Seet, Li Zhen Toh, Stephanie W. L. Chu, Sharon N. Finger, Jocelyn L. L. Chua, Tina T. Wong
    Disease Models & Mechanisms 2017 10: 751-760; doi: 10.1242/dmm.028555

    Summary: As well as providing an objective quantitative measure, distinct collagen genes may further aid in the characterization and definition of the development of fibrosis.

  • Open Access
    A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects
    Jennifer A. Suggs, Girish C. Melkani, Bernadette M. Glasheen, Mia M. Detor, Anju Melkani, Nathan P. Marsan, Douglas M. Swank, Sanford I. Bernstein
    Disease Models & Mechanisms 2017 10: 761-771; doi: 10.1242/dmm.028050

    Summary: Reduced muscle power output and progressive myofibrillar defects in a Drosophila model of inclusion body myopathy 3 arise from the decreased rate of weak to strong actin-binding transition of myosin.

  • Open Access
    A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress
    Sian E. Piret, Eric Olinger, Anita A. C. Reed, M. Andrew Nesbit, Tertius A. Hough, Liz Bentley, Olivier Devuyst, Roger D. Cox, Rajesh V. Thakker
    Disease Models & Mechanisms 2017 10: 773-786; doi: 10.1242/dmm.029488

    Summary: A mouse model for renal fibrosis caused by uromodulin mutations reveals roles for ER stress and the unfolded protein response.

  • Open Access
    Progesterone induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in rats
    Syed Suhail Andrabi, Suhel Parvez, Heena Tabassum
    Disease Models & Mechanisms 2017 10: 787-796; doi: 10.1242/dmm.025692

    Summary: Progesterone treatment is beneficial in preserving the altered mitochondrial functions in cerebral ischemic injury and thus can help in defining better therapies.

RESOURCE ARTICLES

  • Open Access
    A classification system for zebrafish adipose tissues
    James E. N. Minchin, John F. Rawls
    Disease Models & Mechanisms 2017 10: 797-809; doi: 10.1242/dmm.025759

    Summary: A standardized nomenclature and classification system for zebrafish adipose tissues and regression models to predict expected adipose size during the course of zebrafish development.

  • Open Access
    A rapid and effective method for screening, sequencing and reporter verification of engineered frameshift mutations in zebrafish
    Sergey V. Prykhozhij, Shelby L. Steele, Babak Razaghi, Jason N. Berman
    Disease Models & Mechanisms 2017 10: 811-822; doi: 10.1242/dmm.026765

    Summary: A new CRISPR/Cas9-based method of fluorescent reporter technology in zebrafish to confirm loss of gene function in this model.

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  • Open Access

    Metabolomics and lipidomics in C. elegans using a single sample preparation

    Marte Molenaars, Bauke V. Schomakers, Hyung L. Elfrink, Arwen W. Gao, Martin A. T. Vervaart, Mia L. Pras-Raves, Angela C. Luyf, Reuben L. Smith, Mark G. Sterken, Jan E. Kammenga, Antoine H. C. van Kampen, Georges E. Janssens, Frédéric M. Vaz, Michel van Weeghel, Riekelt H. Houtkooper
    PDF
  • Open Access

    High dimensional immunotyping of tumors grown in obese and non-obese mice

    Cara E. Wogsland, Hilde E. Lien, Line Pedersen, Pahul Hanjra, Sturla M. Grondal, Rolf A. Brekken, James B. Lorens, Nils Halberg
    PDF
  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
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