AT A GLANCE
- Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
Summary: This at a glance article gives an overview of the recent knowledge mainly derived from rodent models regarding the CNS-dependent regulation of energy and glucose homeostasis, and depicts how dysregulation of the involved neuronal networks promotes overnutrition and obesity.
REVIEW
- Induced pluripotent stem cell models of lysosomal storage disorders
Summary: This Review discusses how induced pluripotent stem cells (iPSCs) provide new opportunities to explore the biology and pathophysiology of lysosomal storage diseases, and how iPSCs have illuminated the role of lysosomes in more common disorders.
RESEARCH ARTICLES
- SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression
Editors' choice: A Drosophila model to study the role of PRODH, a schizophrenia-associated gene, in behavioral disorders.
- Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome
Summary: A mouse model of metabolic syndrome can be used to investigate peripheral nerve damage, enabling the development of mechanism-based therapies for neuropathy.
- Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling
Summary: Paneth cell disruption and bacterial exposure in immature murine intestine induces NEC-like pathology. Importantly, this occurs independently of TLR4 activation, presenting an alternative mechanism for disease development.
- Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases
Summary: Detailed analysis of lipid accumulation, lysosomal dysfunction and neurodegeneration in a Drosophila sphingolipidosis model, suitable for studying the resulting pathological signaling events.
- Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis
Summary: As well as providing an objective quantitative measure, distinct collagen genes may further aid in the characterization and definition of the development of fibrosis.
- A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects
Summary: Reduced muscle power output and progressive myofibrillar defects in a Drosophila model of inclusion body myopathy 3 arise from the decreased rate of weak to strong actin-binding transition of myosin.
- A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress
Summary: A mouse model for renal fibrosis caused by uromodulin mutations reveals roles for ER stress and the unfolded protein response.
- Progesterone induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in rats
Summary: Progesterone treatment is beneficial in preserving the altered mitochondrial functions in cerebral ischemic injury and thus can help in defining better therapies.
RESOURCE ARTICLES
- A classification system for zebrafish adipose tissues
Summary: A standardized nomenclature and classification system for zebrafish adipose tissues and regression models to predict expected adipose size during the course of zebrafish development.
- A rapid and effective method for screening, sequencing and reporter verification of engineered frameshift mutations in zebrafish
Summary: A new CRISPR/Cas9-based method of fluorescent reporter technology in zebrafish to confirm loss of gene function in this model.
This issue
Other journals from The Company of Biologists
Editor’s Choice – Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
Simone Renner and colleagues used a transgenic pig model to show that mild hyperglycemia in insulin-mutant mothers results in poorer glucose tolerance and metabolic disturbances in the offspring, even wild-type ones.
In their article and accompanying poster, Martina Konantz and colleagues summarize the last 20 years of research in zebrafish models for hematopoietic disorders, highlighting how these models were created and are being applied for translational research.
A new Resource article from Susanne Sattler’s group describes a refined MRI technique to quantify acute hemorrhagic myocarditis in mice.
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with Karishma Chhabria, Eleftheria Pervolaraki, Tamio Furuse, Hiroshi Mizuma, Katja Graf, Antonia Last and Monika Tomecka.
DMM joins the Review Commons initiative
Disease Models & Mechanisms is pleased to be a part of the new and exciting Review Commons initiative, launched by EMBO and ASAPbio. Streamlining the publishing process, Review Commons enables high-quality peer review to take place before journal submission. Papers submitted to Review Commons will be assessed independently of any journal, focusing solely on the paper’s scientific rigor and merit.
preLights – preLights reaches 500 posts!
The success of preLights is down to the hard work of our preLighters. Head over to the preLights website to find out more about our most active early-career-researchers.