OBITUARY
REVIEW
- 3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments
Summary: Here, Albritton and Miller discuss recent 3D bioprinting advances that can be used to produce heterogeneous tumor microenvironments for improved physical modeling of cancer metastasis.
RESEARCH ARTICLES
- A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth
Editors' choice: A new brain tumour model in zebrafish allows simultaneous analysis of malignant tumours and heterotopias, suggesting that both lesions originate from similar events, with Yap1 as a driving force in tumour development.
- Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia
Summary: In utero exposure to ethanol causes defects in optic nerve formation by interfering with Shh signaling activity in the growth and differentiation of retinal progenitor cells in the developing mouse eye.
- Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer
Summary: New insights are provided into the role of hedgehog signaling in maintaining prostate smooth muscle and place hedgehog as a candidate pathway of therapeutic value for treating individuals with prostate cancer.
- S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model
Summary: Slc33a1wt/mut knock-in mice with a S113R mutation and exhibiting hereditary spastic paraplegia-related phenotypes show that SLC33A1 negatively regulates BMP signaling and axonal regeneration.
RESOURCE ARTICLE
- Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models
Summary: Standardization of zebrafish echocardiography provides insights into cardiac physiology in normal and diseased states, with application for functional studies in zebrafish models of heart disease.
This issue
Other journals from The Company of Biologists
Editor’s Choice – Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
Simone Renner and colleagues used a transgenic pig model to show that mild hyperglycemia in insulin-mutant mothers results in poorer glucose tolerance and metabolic disturbances in the offspring, even wild-type ones.
In their article and accompanying poster, Martina Konantz and colleagues summarize the last 20 years of research in zebrafish models for hematopoietic disorders, highlighting how these models were created and are being applied for translational research.
A new Resource article from Susanne Sattler’s group describes a refined MRI technique to quantify acute hemorrhagic myocarditis in mice.
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with Karishma Chhabria, Eleftheria Pervolaraki, Tamio Furuse, Hiroshi Mizuma, Katja Graf, Antonia Last and Monika Tomecka.
DMM joins the Review Commons initiative
Disease Models & Mechanisms is pleased to be a part of the new and exciting Review Commons initiative, launched by EMBO and ASAPbio. Streamlining the publishing process, Review Commons enables high-quality peer review to take place before journal submission. Papers submitted to Review Commons will be assessed independently of any journal, focusing solely on the paper’s scientific rigor and merit.
preLights – preLights reaches 500 posts!
The success of preLights is down to the hard work of our preLighters. Head over to the preLights website to find out more about our most active early-career-researchers.