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  Open access

January, 2017; 10 (1)

OBITUARY

  • Open Access
    Susan Lindquist: a tribute
    Vivian Siegel
    Disease Models & Mechanisms 2017 10: 1-2; doi: 10.1242/dmm.028696

REVIEW

  • Open Access
    3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments
    Jacob L. Albritton, Jordan S. Miller
    Disease Models & Mechanisms 2017 10: 3-14; doi: 10.1242/dmm.025049

    Summary: Here, Albritton and Miller discuss recent 3D bioprinting advances that can be used to produce heterogeneous tumor microenvironments for improved physical modeling of cancer metastasis.

RESEARCH ARTICLES

  • Open Access
    A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth
    Marie Mayrhofer, Victor Gourain, Markus Reischl, Pierre Affaticati, Arnim Jenett, Jean-Stephane Joly, Matteo Benelli, Francesca Demichelis, Pietro Luigi Poliani, Dirk Sieger, Marina Mione
    Disease Models & Mechanisms 2017 10: 15-28; doi: 10.1242/dmm.026500

    Editors' choice: A new brain tumour model in zebrafish allows simultaneous analysis of malignant tumours and heterotopias, suggesting that both lesions originate from similar events, with Yap1 as a driving force in tumour development.

  • Open Access
    Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia
    Benjamin M. Kahn, Tanya S. Corman, Korah Lovelace, Mingi Hong, Robert S. Krauss, Douglas J. Epstein
    Disease Models & Mechanisms 2017 10: 29-37; doi: 10.1242/dmm.026195

    Summary: In utero exposure to ethanol causes defects in optic nerve formation by interfering with Shh signaling activity in the growth and differentiation of retinal progenitor cells in the developing mouse eye.

  • Open Access
    Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer
    Zhaohui Yang, Yu-Ching Peng, Anuradha Gopalan, Dong Gao, Yu Chen, Alexandra L. Joyner
    Disease Models & Mechanisms 2017 10: 39-52; doi: 10.1242/dmm.027417

    Summary: New insights are provided into the role of hedgehog signaling in maintaining prostate smooth muscle and place hedgehog as a candidate pathway of therapeutic value for treating individuals with prostate cancer.

  • Open Access
    S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model
    Pingting Liu, Baichun Jiang, Jian Ma, Pengfei Lin, Yinshuai Zhang, Changshun Shao, Wenjie Sun, Yaoqin Gong
    Disease Models & Mechanisms 2017 10: 53-62; doi: 10.1242/dmm.026880

    Summary: Slc33a1wt/mut knock-in mice with a S113R mutation and exhibiting hereditary spastic paraplegia-related phenotypes show that SLC33A1 negatively regulates BMP signaling and axonal regeneration.

RESOURCE ARTICLE

  • Open Access
    Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models
    Louis W. Wang, Inken G. Huttner, Celine F. Santiago, Scott H. Kesteven, Ze-Yan Yu, Michael P. Feneley, Diane Fatkin
    Disease Models & Mechanisms 2017 10: 63-76; doi: 10.1242/dmm.026989

    Summary: Standardization of zebrafish echocardiography provides insights into cardiac physiology in normal and diseased states, with application for functional studies in zebrafish models of heart disease.

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  • Open Access

    Joint development recovery on resumption of embryonic movement following paralysis

    Rebecca A. Rolfe, David Scanlon O'Callaghan, Paula Murphy
    PDF
  • Open Access

    Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

    Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Adeline Bourgeois, Pedro Magalhães, Maria Kuzma-Kuzniarska, Celine Lesaulnier, Martin Rezko, Edwige Declercq, Petra Zürbig, Alain Doucet, Muriel Umbhauer, Silvia Cereghini
    PDF
  • Open Access

    An Fgfr3-activating mutation in immature osteoblasts affects the appendicular and craniofacial skeleton

    Martin Biosse Duplan, Emilie Dambroise, Valentin Estibals, Joelle Veziers, Jérome Guicheux, Laurence Legeai-Mallet
    PDF
  • Open Access

    Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome

    Beverly A. Karpinski, Thomas M. Maynard, Corey A. Bryan, Gelila Yitsege, Anelia Horvath, Norman H. Lee, Sally A. Moody, Anthony-Samuel LaMantia
    PDF
  • Open Access

    Sex differences in insulin resistance but not peripheral neuropathy in a diet-induced prediabetes mouse model

    Sarah E. Elzinga, Masha G. Savelieff, Phillipe D. O'Brien, Faye E. Mendelson, John M. Hayes, Eva L. Feldman
    PDF
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DMM and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

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The twin pillars of Disease Models & Mechanisms

In her first Editorial as Editor-in-Chief, Liz Patton sets out her vision and priorities for DMM focusing on four thematic challenges: mechanisms of disease, innovative technologies, disease progression through time and therapy.


Extended deadline - The RAS Pathway: Diseases, Therapeutics and Beyond

Our upcoming special issue is welcoming submissions until 3 May 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on the targeting the RAS pathway.

Find out more about the issue and how to submit your manuscript.


Perspective - Modelling the developmental origins of paediatric cancer to improve patient outcomes

James Amatruda authors our first Perspective, discussing some of the key challenges in paediatric cancer from his perspective as a physician-scientist.


A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities

In this issue’s Editor’s choice, Ketan Patel and colleagues describe how even brief exposure to muscle-growth-promoting treatments exerts a long-term detrimental effect on the testes, and test promising therapeutics to mitigate this side-effect.

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