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Subject collection: Zebrafish as a Disease Model

  • RESEARCH ARTICLE
    Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model
    Yan Li, Ira Agrawal, Zhiyuan Gong
    Disease Models & Mechanisms 2019 12: dmm039578 doi: 10.1242/dmm.039578 Published 17 October 2019

    Summary: In an oncogene-addicted liver cancer zebrafish model, transformed cancer hepatocytes could be reverted to normal hepatocytes, as shown by Cre-loxP-mediated cell-lineage tracing.

  • RESEARCH ARTICLE
    Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish
    Yonghe Ding, Alexey V. Dvornikov, Xiao Ma, Hong Zhang, Yong Wang, Matthew Lowerison, Rene R. Packard, Lei Wang, Jun Chen, Yuji Zhang, Tzung Hsiai, Xueying Lin, Xiaolei Xu
    Disease Models & Mechanisms 2019 12: dmm040154 doi: 10.1242/dmm.040154 Published 1 October 2019

    Summary: This study shows that adult bag3 knockout mutant zebrafish can be used as a model for DCM, and haploinsufficiency of mTOR is cardioprotective.

  • RESEARCH ARTICLE
    Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish
    Karishma Chhabria, Avgoustinos Vouros, Caroline Gray, Ryan B. MacDonald, Zhen Jiang, Robert Neil Wilkinson, Karen Plant, Eleni Vasilaki, Clare Howarth, Timothy J. A. Chico
    Disease Models & Mechanisms 2019 12: dmm039867 doi: 10.1242/dmm.039867 Published 25 September 2019

    Summary: Diabetes is associated with vascular and neurological impairments. The authors show that an NO donor ameliorates the glucose-exposure-induced dysfunction in the tectal neurovascular unit and whole-organism behaviour.

  • AT A GLANCE
    Modeling hematopoietic disorders in zebrafish
    Martina Konantz, Christoph Schürch, Pauline Hanns, Joëlle S. Müller, Loïc Sauteur, Claudia Lengerke
    Disease Models & Mechanisms 2019 12: dmm040360 doi: 10.1242/dmm.040360 Published 6 September 2019

    Summary: This At A Glance article and poster summarize the last 20 years of research in zebrafish models for hematopoietic disorders, highlighting how these models were created and are being applied for translational research.

  • RESEARCH ARTICLE
    Clinical pathologies of bone fracture modelled in zebrafish
    Monika J. Tomecka, Lalith P. Ethiraj, Luis M. Sánchez, Henry H. Roehl, Tom J. Carney
    Disease Models & Mechanisms 2019 12: dmm037630 doi: 10.1242/dmm.037630 Published 3 September 2019

    Summary: The effect of osteogenesis imperfecta, bisphosphonate treatment and bacterial infection on phases of bone fracture repair are determined using a zebrafish fracture model.

  • RESEARCH ARTICLE
    Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease
    Ling-shiang Chuang, Joshua Morrison, Nai-yun Hsu, Philippe Ronel Labrias, Shikha Nayar, Ernie Chen, Nicole Villaverde, Jody Ann Facey, Gilles Boschetti, Mamta Giri, Mireia Castillo-Martin, Tin Htwe Thin, Yashoda Sharma, Jaime Chu, Judy H. Cho
    Disease Models & Mechanisms 2019 12: dmm037432 doi: 10.1242/dmm.037432 Published 13 August 2019

    Summary: As IBD attempts to enter the era of precision medicine, our models provide an opportunity for the rapid and sophisticated determination of time course, cellular contributions and mechanisms of new drugs.

  • REVIEW
    The zebrafish subcortical social brain as a model for studying social behavior disorders
    Yijie Geng, Randall T. Peterson
    Disease Models & Mechanisms 2019 12: dmm039446 doi: 10.1242/dmm.039446 Published 6 August 2019

    Summary: The zebrafish has become an increasingly attractive model for studying social behavior disorders. This Review summarizes relevant methods, established social deficit models, emerging technologies and the anatomical basis of sociality.

  • RESEARCH ARTICLE
    Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
    Gianluca D'Agati, Elena María Cabello, Karl Frontzek, Elisabeth J. Rushing, Robin Klemm, Mark D. Robinson, Richard M. White, Christian Mosimann, Alexa Burger
    Disease Models & Mechanisms 2019 12: dmm039545 doi: 10.1242/dmm.039545 Published 16 July 2019

    Summary: An injection-based chordoma model in zebrafish shows that the hypothesized chordoma oncogene brachyury is insufficient, whereas EGFR and VEGFR2 are sufficient, to trigger notochord hyperplasia in our model.

  • RESEARCH ARTICLE
    Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK,ACh)
    Christiaan C. Veerman, Isabella Mengarelli, Charlotte D. Koopman, Ronald Wilders, Shirley C. van Amersfoorth, Diane Bakker, Rianne Wolswinkel, Mariam Hababa, Teun P. de Boer, Kaomei Guan, James Milnes, Elisabeth M. Lodder, Jeroen Bakkers, Arie O. Verkerk, Connie R. Bezzina
    Disease Models & Mechanisms 2019 12: dmm037994 doi: 10.1242/dmm.037994 Published 9 July 2019

    Summary: The authors show hiPSC-cardiomyocyte-based modeling of a mutation in a G-protein β-subunit that affects the electrophysiological response of cardiomyocytes to the cholinergic regulation of the heart rate, uncovering a potential therapy for severe bradycardia in humans carrying these mutations.

  • RESEARCH ARTICLE
    Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration
    Yufei Xie, Sofie Tolmeijer, Jelle M. Oskam, Tijs Tonkens, Annemarie H. Meijer, Marcel J. M. Schaaf
    Disease Models & Mechanisms 2019 12: dmm037887 doi: 10.1242/dmm.037887 Published 30 May 2019

    Summary: In a zebrafish model for inflammation, glucocorticoids do not affect the migration of macrophages, but inhibit their differentiation towards an M1 phenotype, by strongly attenuating transcriptional responses in these cells.

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