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Subject collection: Rat as a Disease Model

  • RESEARCH ARTICLE
    Predicting experimental success: a retrospective case-control study using the rat intraluminal thread model of stroke
    Lisa Liebenstund, Mark Coburn, Christina Fitzner, Antje Willuweit, Karl-Josef Langen, Jingjin Liu, Michael Veldeman, Anke Höllig
    Disease Models & Mechanisms 2020 13: dmm044651 doi: 10.1242/dmm.044651 Published 29 December 2020

    Summary: An assessment of the importance of peri-interventional monitoring to verify a successful experimental performance in order to ensure a disease model that is as homogeneous as possible.

  • RESEARCH ARTICLE
    Pathological evaluation of rats carrying in-frame mutations in the dystrophin gene: a new model of Becker muscular dystrophy
    Naomi Teramoto, Hidetoshi Sugihara, Keitaro Yamanouchi, Katsuyuki Nakamura, Koichi Kimura, Tomoko Okano, Takanori Shiga, Taku Shirakawa, Masafumi Matsuo, Tetsuya Nagata, Masao Daimon, Takashi Matsuwaki, Masugi Nishihara
    Disease Models & Mechanisms 2020 13: dmm044701 doi: 10.1242/dmm.044701 Published 28 September 2020

    Editor's choice: The newly established rat model carrying in-frame mutations in the Dmd gene exhibits the dystrophic phenotype and abnormal dystrophin expression profile, similar to patients with Becker muscular dystrophy.

  • RESEARCH ARTICLE
    Nrf2/HO-1 mediates the neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury in rats
    Mohd. Salman, Heena Tabassum, Suhel Parvez
    Disease Models & Mechanisms 2020 13: dmm045021 doi: 10.1242/dmm.045021 Published 19 August 2020

    Editor's choice: We administered pramipexole (PPX) to rats after a traumatic brain injury (TBI) and evaluated various parameters, which indicate that the neuroprotective effects of PPX are mediated by activation of the Nrf2/HO-1 signaling pathway following TBI.

  • RESEARCH ARTICLE
    Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats
    Eunjo Lee, Namkyung Kim, Jinjoo Kang, Sangwon Yoon, Hae-Ahm Lee, Hanna Jung, Sang-Hyun Kim, Inkyeom Kim
    Disease Models & Mechanisms 2020 13: dmm044107 doi: 10.1242/dmm.044107 Published 27 May 2020

    Summary: Activation of pathogenic Th17 lymphocytes induces hypertension after high-fructose intake in salt-sensitive rats. Immune activation plays an important role in the development of hypertension, whereas immune tolerance is protective against hypertension.

  • RESEARCH ARTICLE
    Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model
    Desislava Doycheva, Ningbo Xu, Harpreet Kaur, Jay Malaguit, Devin William McBride, Jiping Tang, John H. Zhang
    Disease Models & Mechanisms 2019 12: dmm040352 doi: 10.1242/dmm.040352 Published 22 November 2019

    Summary: Elucidating the role of Bax inhibitor 1 (BI-1) and its mechanisms in the pathophysiology of hypoxic ischemic encephalopathy may help provide a basis for BI-1 as a potential therapeutic target in clinics.

  • RESEARCH ARTICLE
    Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam
    A. Scott Emmert, Eri Iwasawa, Crystal Shula, Preston Schultz, Diana Lindquist, R. Scott Dunn, Elizabeth M. Fugate, Yueh-Chiang Hu, Francesco T. Mangano, June Goto
    Disease Models & Mechanisms 2019 12: dmm040972 doi: 10.1242/dmm.040972 Published 21 November 2019

    Summary: Glymphatic CSF circulation and development of the cerebral cortex are impaired in our new genetic rat model of neonatal hydrocephalus with the onset of parenchymal inflammation and hemorrhage.

  • RESEARCH ARTICLE
    Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke
    Syed Suhail Andrabi, Mubashshir Ali, Heena Tabassum, Sabiha Parveen, Suhel Parvez
    Disease Models & Mechanisms 2019 12: dmm033860 doi: 10.1242/dmm.033860 Published 29 August 2019

    Summary: Pramipexole produced neurological recovery through mitochondrial-mediated survival pathways in ischemic stroke.

  • RESEARCH ARTICLE
    Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance
    Georg W. Otto, Pamela J. Kaisaki, Francois Brial, Aurélie Le Lay, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier
    Disease Models & Mechanisms 2019 12: dmm038539 doi: 10.1242/dmm.038539 Published 15 July 2019

    Summary: Kidney and fat expression QTL mapping in rat models of spontaneously occurring insulin resistance associated with either diabetes or hypertension reveals conserved gene expression regulation, suggesting shared aetiology of disease phenotypes.

  • RESEARCH ARTICLE
    Increased levels of synaptic proteins involved in synaptic plasticity after chronic intraocular pressure elevation and modulation by brain-derived neurotrophic factor in a glaucoma animal model
    Hae-Young Lopilly Park, Si Won Kim, Jie Hyun Kim, Chan Kee Park
    Disease Models & Mechanisms 2019 12: dmm037184 doi: 10.1242/dmm.037184 Published 18 June 2019

    Summary: Application of BDNF increased the expression of synaptic vesicle proteins in the inner retina via the p-Akt, CaMKII and CREB pathways, increasing F-actin in RGC dendrites.

  • RESEARCH ARTICLE
    Effects of subthalamic deep brain stimulation on striatal metabolic connectivity in a rat hemiparkinsonian model
    Nadine Apetz, Elena Kordys, Mascha Simon, Britta Mang, Markus Aswendt, Dirk Wiedermann, Bernd Neumaier, Alexander Drzezga, Lars Timmermann, Heike Endepols
    Disease Models & Mechanisms 2019 12: dmm039065 doi: 10.1242/dmm.039065 Published 24 May 2019

    Summary: Deep brain stimulation in the subthalamic nucleus in rats with a unilateral dopaminergic lesion established a new functional interhemispheric striatal network.

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