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Subject collection: Organoids

  • RESEARCH ARTICLE
    Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
    Katie Lloyd, Stamatia Papoutsopoulou, Emily Smith, Philip Stegmaier, Francois Bergey, Lorna Morris, Madeleine Kittner, Hazel England, Dave Spiller, Mike H. R. White, Carrie A. Duckworth, Barry J. Campbell, Vladimir Poroikov, Vitor A. P. Martins dos Santos, Alexander Kel, Werner Muller, D. Mark Pritchard, Chris Probert, Michael D. Burkitt, The SysmedIBD Consortium
    Disease Models & Mechanisms 2020 13: dmm044040 doi: 10.1242/dmm.044040 Published 27 November 2020

    Summary: Using state-of-the-art in silico drug discovery and real-time live-cell imaging techniques, we identify clarithromycin as a drug with potential for repositioning for inflammatory bowel disease.

  • RESEARCH ARTICLE
    Inhibition of Alk signaling promotes the induction of human salivary-gland-derived organoids
    Shohei Yoshimoto, Junko Yoshizumi, Hiromasa Anzai, Koichiro Morishita, Kazuhiko Okamura, Akimitsu Hiraki, Shuichi Hashimoto
    Disease Models & Mechanisms 2020 13: dmm045054 doi: 10.1242/dmm.045054 Published 28 September 2020

    Summary: Human salivary-gland-derived organoids can be used for in vitro analyses of the morphological and functional changes associated with salivary gland diseases and dysfunctions.

  • REVIEW
    Neuromuscular disease modeling on a chip
    Jeffrey W. Santoso, Megan L. McCain
    Disease Models & Mechanisms 2020 13: dmm044867 doi: 10.1242/dmm.044867 Published 7 July 2020

    Summary: Modeling neuromuscular diseases is challenging due to their complex etiology and pathophysiology. Here, we review the cell sources and tissue-engineering procedures that are being integrated as emerging neuromuscular disease models.

  • RESOURCE ARTICLE
    Human embryoid bodies as a 3D tissue model of the extracellular matrix and α-dystroglycanopathies
    Alec R. Nickolls, Michelle M. Lee, Kristen Zukosky, Barbara S. Mallon, Carsten G. Bönnemann
    Disease Models & Mechanisms 2020 13: dmm042986 doi: 10.1242/dmm.042986 Published 26 June 2020

    Summary: Human stem cell culture methods enable the generation of extracellular matrix-containing tissue to study patient-specific pathology and experimental treatment of the α-dystroglycanopathies.

  • REVIEW
    Precision-based modeling approaches for necrotizing enterocolitis
    Mark L. Kovler, Chhinder P. Sodhi, David J. Hackam
    Disease Models & Mechanisms 2020 13: dmm044388 doi: 10.1242/dmm.044388 Published 24 June 2020

    Summary: Much of our understanding of necrotizing enterocolitis (NEC) pathogenesis has been achieved through animal models. Here, we discuss the development of advanced precision-based models to improve outcomes for patients with NEC.

  • AT A GLANCE
    Disease modelling in human organoids
    Madeline A. Lancaster, Meritxell Huch
    Disease Models & Mechanisms 2019 12: dmm039347 doi: 10.1242/dmm.039347 Published 29 July 2019

    Summary: Human organoids are important tools for modelling disease. This At a Glance article summarises the current organoid models of several human diseases, and discusses future prospects for these technologies.

  • RESEARCH ARTICLE
    Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy
    Emily J. Jones, Zoe J. Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina Divekar, Jasmine Buck, Tomasz Wrzesinski, Matthew Jefferson, Stuart D. Armstrong, Lindsay J. Hall, Alastair J. M. Watson, Simon R. Carding, Wilfried Haerty, Federica Di Palma, Ulrike Mayer, Penny P. Powell, Isabelle Hautefort, Tom Wileman, Tamas Korcsmaros
    Disease Models & Mechanisms 2019 12: dmm037069 doi: 10.1242/dmm.037069 Published 18 March 2019

    Editor's choice: Using an integrative approach encompassing intestinal organoid culture, proteomics, transcriptomics and protein-protein interaction networks, we list Paneth cell functions dependent on autophagy.

  • REVIEW
    Modeling epigenetic modifications in renal development and disease with organoids and genome editing
    Carmen Hurtado del Pozo, Elena Garreta, Juan Carlos Izpisúa Belmonte, Nuria Montserrat
    Disease Models & Mechanisms 2018 11: dmm035048 doi: 10.1242/dmm.035048 Published 20 November 2018

    Summary: In this Review, we provide an overview on how epigenetic processes are altered in kidney development and disease, and discuss how CRISPR-modified kidney organoids can help us to understand the function of epigenetic marks.

  • RESEARCH ARTICLE
    Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates
    Yuliya Klymenko, Rebecca B. Wates, Holly Weiss-Bilka, Rachel Lombard, Yueying Liu, Leigh Campbell, Oleg Kim, Diane Wagner, Matthew J. Ravosa, M. Sharon Stack
    Disease Models & Mechanisms 2018 11: dmm034199 doi: 10.1242/dmm.034199 Published 25 September 2018

    Summary: Development of new model systems with which to evaluate cellular responses to compression enables experimental modeling of the intraperitoneal force environment of ovarian cancer patients with tense ascites.

  • REVIEW
    Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
    Jelle J. F. Sleeboom, Hossein Eslami Amirabadi, Poornima Nair, Cecilia M. Sahlgren, Jaap M. J. den Toonder
    Disease Models & Mechanisms 2018 11: dmm033100 doi: 10.1242/dmm.033100 Published 16 March 2018

    Summary: This Review evaluates the recent contributions of cancer-on-a-chip models to our understanding of the tumor microenvironment and its role in the onset of metastasis. The authors also provide an outlook for future applications of this emerging technology.

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