Subject collection: Organoids
- Disease modelling in human organoids
Summary: Human organoids are important tools for modelling disease. This At a Glance article summarises the current organoid models of several human diseases, and discusses future prospects for these technologies.
- Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy
Editor's choice: Using an integrative approach encompassing intestinal organoid culture, proteomics, transcriptomics and protein-protein interaction networks, we list Paneth cell functions dependent on autophagy.
- Modeling epigenetic modifications in renal development and disease with organoids and genome editing
Summary: In this Review, we provide an overview on how epigenetic processes are altered in kidney development and disease, and discuss how CRISPR-modified kidney organoids can help us to understand the function of epigenetic marks.
- Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models
Summary: Gastroenteropancreatic neuroendocrine neoplasms have been an understudied entity with limited treatment options. We discuss the disease models, including emerging organoids, that may provide biological and therapeutic insight into these diseases.
- Modelling glioblastoma tumour-host cell interactions using adult brain organotypic slice co-culture
Editor's choice: A new ex vivo experimental approach to explore how glioblastoma stem cells interact with distinct brain microenvironments, with potential use a as preclinical model using new anticancer agents.
- Renal carcinoma/kidney progenitor cell chimera organoid as a novel tumorigenesis gene discovery model
Editor’s Choice: Chimeras between embryonic kidney cells and renal carcinoma cells serve as a novel model to assay the roles of co-regulated genes in kidney development and renal carcinogenesis.
- Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo
Editors’ choice: Wnt signalling regulates homeostasis of the gastric epithelium via the Fzd7 receptor, which could be a target for therapeutic intervention in gastric cancer.
- Waging war against pancreatic cancer: an interview with David Tuveson
Summary: David Tuveson describes some of the key moments and breakthroughs in his remarkable career, and the path that he's followed in his quest for a cure for pancreatic cancer.
- Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models
Summary: Helicobacter pylori-induced gastric pathology remains a common cause of morbidity and mortality. This Review discusses the animal models of these conditions, together with recently described ex vivo culture models.
- 3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments
Summary: Here, Albritton and Miller discuss recent 3D bioprinting advances that can be used to produce heterogeneous tumor microenvironments for improved physical modeling of cancer metastasis.