Subject collection: Neurodegenerative Disorders
- A differential autophagy-dependent response to DNA double-strand breaks in bone marrow mesenchymal stem cells from sporadic ALS patients
Summary: A novel endogenous disease mechanism in cells from ALS patients after NCS-induced DNA damage.
- Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario
Summary: Grb2 has a unique role in protecting the cytoskeletal architecture in AD-like conditions, offering a potential new strategy for controlling neurodegeneration.
- Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes
Summary: In vitro systems derived from AD mice can be used to investigate the vulnerability of AD neurons to different neurotoxic challenges, including oxygen glucose deprivation.
- Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models
Summary: PACAP has a neuroprotective effect in different toxin-induced rat and snail parkinsonian models, acting partially through the same mechanisms.
- S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model
Summary: Slc33a1wt/mut knock-in mice with a S113R mutation and exhibiting hereditary spastic paraplegia-related phenotypes show that SLC33A1 negatively regulates BMP signaling and axonal regeneration.
- Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity
Editors' choice: Cultured Parkinson's disease lymphocytes are metabolically hyperactive, suggesting a new understanding of the underlying cytopathology and biomarkers for this and potentially other neurodegenerative diseases.
- HSV presence in brains of individuals without dementia: the TASTY brain series
Summary: We assessed the presence of HSV types 1 and 2 in the brain tissue of a large non-institutionalised autopsy cohort, providing evidence of asymptomatic access of HSV to the brain.
- Rodent models in neuroscience research: is it a rat race?
Summary: In this At a Glance poster review, Ellenbroek and Youn describe important differences between rats and mice that impact on their use as model organisms for brain disorders.
- A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice
Summary: A high-fat diet extends lifespan in a TDP-43 mutant mouse model of motor neuron disease and might be a possible treatment strategy for individuals with amyotrophic lateral sclerosis.