Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Disease Models & Mechanisms
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Disease Models & Mechanisms

Advanced search

RSS   Twitter   Facebook   YouTube

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback

Subject collection: Neurodegenerative Disorders

  • RESEARCH ARTICLE
    Inducible expression of human C9ORF72 36× G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice
    Fréderike W. Riemslagh, Esmay C. van der Toorn, Rob F. M. Verhagen, Alex Maas, Laurens W. J. Bosman, Renate K. Hukema, Rob Willemsen
    Disease Models & Mechanisms 2021 14: dmm044842 doi: 10.1242/dmm.044842 Published 16 February 2021

    Summary: Only 36 C9ORF72 repeats are sufficient for RAN translation in a new mouse model for amyotrophic lateral sclerosis and frontotemporal dementia. Reducing toxic dipeptides can prevent but not reverse the phenotype.

  • RESEARCH ARTICLE
    TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
    Rachel Atkinson, Jacqueline Leung, James Bender, Matthew Kirkcaldie, James Vickers, Anna King
    Disease Models & Mechanisms 2021 14: dmm047548 doi: 10.1242/dmm.047548 Published 11 February 2021

    Summary: We examined the cellular effects of mislocalization of TDP-43, a key pathological protein in amyotrophic lateral sclerosis and frontotemporal dementia, using the eye as a model and demonstrated axonal cytoskeleton alterations.

  • RESEARCH ARTICLE
    Mistargeting of secretory cargo in retromer-deficient cells
    Sarah D. Neuman, Erica L. Terry, Jane E. Selegue, Amy T. Cavanagh, Arash Bashirullah
    Disease Models & Mechanisms 2021 14: dmm046417 doi: 10.1242/dmm.046417 Published 22 January 2021

    Summary: Using Drosophila larval salivary glands as a model system, we show a new role for retromer in trafficking of secretory membrane and cargo proteins during regulated exocytosis, which could be relevant in neurodegenerative diseases.

  • RESEARCH ARTICLE
    Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB
    Ian Adams, Tao Yang, Frank M. Longo, David M. Katz
    Disease Models & Mechanisms 2020 13: dmm044685 doi: 10.1242/dmm.044685 Published 27 November 2020

    Editor's choice: Long-term intermittent treatment with a newly developed partial agonist of the TrkB neurotrophin receptor reverses deficits in motor learning and respiration in a mouse model of Rett syndrome.

  • AT A GLANCE
    Modeling neurodegeneration in Caenorhabditis elegans
    Kim A. Caldwell, Corey W. Willicott, Guy A. Caldwell
    Disease Models & Mechanisms 2020 13: dmm046110 doi: 10.1242/dmm.046110 Published 26 October 2020

    Summary: While unsurpassed as an experimental system for fundamental biology, Caenorhabditis elegans remains undervalued for its translational potential. Here, we highlight significant outcomes from, and resources available for, C. elegans-based research into neurodegenerative disorders.

  • RESEARCH ARTICLE
    Machine learning discriminates a movement disorder in a zebrafish model of Parkinson's disease
    Gideon L. Hughes, Michael A. Lones, Matthew Bedder, Peter D. Currie, Stephen L. Smith, Mary Elizabeth Pownall
    Disease Models & Mechanisms 2020 13: dmm045815 doi: 10.1242/dmm.045815 Published 16 October 2020

    Summary: Using computational analyses to harness artificial intelligence, we have tested a genetic model of Parkinson's disease and reveal a distinct movement phenotype in adult zebrafish lacking Dj-1.

  • RESEARCH ARTICLE
    CHIP mutations affect the heat shock response differently in human fibroblasts and iPSC-derived neurons
    S. Schuster, E. Heuten, A. Velic, J. Admard, M. Synofzik, S. Ossowski, B. Macek, S. Hauser, L. Schöls
    Disease Models & Mechanisms 2020 13: dmm045096 doi: 10.1242/dmm.045096 Published 12 October 2020

    Summary: Cell viability, expression and immunocytochemical analyses reveal that mutations in STUB1 that cause SCAR16 impair the heat-shock response in patient-derived fibroblasts, but not in iPSC-derived cortical neurons.

  • REVIEW
    Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders
    Julia Gamache, Young Yun, Ornit Chiba-Falek
    Disease Models & Mechanisms 2020 13: dmm045211 doi: 10.1242/dmm.045211 Published 27 August 2020

    Summary: The APOE ε4 allele and female sex are among the strongest risk factors for late-onset Alzheimer's disease. We explore how the interplay between these factors affects risk for this and other age-related neurodegenerative diseases.

  • RESEARCH ARTICLE
    Early evidence of delayed oligodendrocyte maturation in the mouse model of mucolipidosis type IV
    Molly Mepyans, Livia Andrzejczuk, Jahree Sosa, Sierra Smith, Shawn Herron, Samantha DeRosa, Susan A. Slaugenhaupt, Albert Misko, Yulia Grishchuk, Kirill Kiselyov
    Disease Models & Mechanisms 2020 13: dmm044230 doi: 10.1242/dmm.044230 Published 30 July 2020

    Summary: We show that loss of the lysosomal channel TRPML1, responsible for mucolipidosis IV, leads to delayed maturation of oligodendrocytes in early postnatal development, resulting in brain hypomyelination.

  • RESEARCH ARTICLE
    Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia
    Daniel Fil, Balu K. Chacko, Robbie Conley, Xiaosen Ouyang, Jianhua Zhang, Victor M. Darley-Usmar, Aamir R. Zuberi, Cathleen M. Lutz, Marek Napierala, Jill S. Napierala
    Disease Models & Mechanisms 2020 13: dmm045229 doi: 10.1242/dmm.045229 Published 27 July 2020

    Summary: Sole expression of the mutant frataxin G127V protein is sufficient for viability of the first Friedreich's ataxia point mutation mouse model, but induces premature senescence in isolated cells.

Pages

  • Next
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • …
  • 13

Other subject collections

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Subject collections
  • Interviews
  • Sign up for alerts

About us

  • About DMM
  • Editors and Board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact DMM
  • Advertising
  • Feedback

Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992